Výsledky vyhledávání - "S.C. Hasmall"

Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens

Autor: L. John R. Foster, Ian Kimber, Clifford R Elcombe, J. Odum, John Ashby, Anthony R. Soames, S.C. Hasmall, Susan Stone

Publikováno v: Environmental Health Perspectives

We studied nine presumed nongenotoxic rodent carcinogens, as defined by the U.S. National Toxicology Program (NTP), to determine their ability to induce acute or subacute biochemical and tissue changes that may act as useful predictors of nongenotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6ab41d6e7009d7aaf92e49d9e7bab0
https://doi.org/10.1289/ehp.02110363

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Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis

Autor: Brindle Rd, Neil H. James, Jason H. Gill, Jonathan Tugwood, M Rolfe, S.C. Hasmall, Nicola J. Woodyatt, Neil Macdonald, Ruth A. Roberts, Peter R. Holden

Publikováno v: Toxicology Letters. :91-96

Peroxisome proliferators (PPs) are a class of non-genotoxic rodent hepatocarcinogens that act by perturbing liver growth regulation. We have demonstrated previously that PPs suppress both spontaneous rat hepatocyte apoptosis and that induced by exoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f7d0fac65f97364398be5cd0a5e28
https://doi.org/10.1016/s0378-4274(98)00291-4

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The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

Autor: Clifford R. Elcombe, M Dickins, S.C. Hasmall, Neill J. Horley, David R. Bell, Nick Plant

Publikováno v: Carcinogenesis. 19:1521-1527

The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1412e047d4dc66d2573e01986050e3c8
https://doi.org/10.1093/carcin/19.9.1521

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PPAR alpha and the regulation of cell division and apoptosis

Autor: S.C. Hasmall, Sabina Cosulich, Ruth A. Roberts, Neil H. James, Neil Macdonald, Stephan Chevalier

Publikováno v: Europe PubMed Central

Peroxisome proliferators (PPs) such as the hypolipidaemic drug, nafenopin and the phthalate plasticiser 2-diethylhexylphthalate induce rodent hepatocyte cell proliferation and suppress apoptosis leading to tumours. PPs act via the nuclear hormone rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1af13c770ef2c84e7d2c96d8f737270
https://pubmed.ncbi.nlm.nih.gov/12505304

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Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis

Autor: George Orphanides, Kathryn Hedley, Neil H. James, Anthony R. Soames, S.C. Hasmall, Ruth A. Roberts, William D. Pennie, Ian Kimber

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 68(2)

PPARalpha (peroxisome proliferator activated receptor alpha) is a transcription factor that mediates the rodent liver tumorigenic responses to peroxisome proliferators via regulation of genes that remain to be identified. Using microarray gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d28acbf3d7bf5e4875740a48211a6af
https://pubmed.ncbi.nlm.nih.gov/12151626

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Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha)

Autor: Neil James, S.C. Hasmall, Ruth A. Roberts, Kine Olsen, Kathryn Hedley

Publikováno v: Archives of toxicology. 75(6)

Peroxisome proliferators (PPs) are rodent nongenotoxic hepatocarcinogens that induce peroxisome proliferation and DNA synthesis, and suppress apoptosis in rodent hepatocytes. PPs act through the PP-activated receptor alpha (PPARalpha); tumour necrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd41a29856d712c3f0de678bd4abfe3
https://pubmed.ncbi.nlm.nih.gov/11570693

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Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?

Autor: Ruth A. Roberts, George Orphanides, S.C. Hasmall, S. Cosulich, N.H. James

Publikováno v: Toxicology letters. 120(1-3)

Chemicals with the potential to cause cancer through damaging DNA can be readily identified in a range of in vitro screens that detect genotoxicity. However, many carcinogens are non-genotoxic yet cause rodent tumours, particularly in the liver. Some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2baed6c85482fc24f66f0403890fa19
https://pubmed.ncbi.nlm.nih.gov/11323188

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