Zobrazeno 1 - 10
of 39
pro vyhledávání: '"S.A. Mady"'
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
PDF - 3347KB, Synthesis and characterization of the lead compound 1 (UMI-59) and its analog 2 (UMI-77), additional details for used methods, and nine supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ebe7752694e8e0d74d2d706ad75de
https://doi.org/10.1158/1535-7163.22500082.v1
https://doi.org/10.1158/1535-7163.22500082.v1
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486b43ad56418f83c2937c579d90f8f3
https://doi.org/10.1158/1535-7163.c.6536347
https://doi.org/10.1158/1535-7163.c.6536347
Autor:
Mohan Pal, Lei Miao, Andrej Perdih, Jacob M. Carlson, Nurul H. Ansari, Yuting Yang, Zaneta Nikolovska-Coleska, Jennifer L. Meagher, Jeanne A. Stuckey, Chenzhong Liao, Karson J. Kump, Ahmed S.A. Mady, Fardokht A. Abulwerdi, May Khanna, Uttar K. Shrestha, Krishnapriya Chinnaswamy
Publikováno v:
J Med Chem
Anti-apoptotic Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated therapeutic targets. Cancer cells display survival dependence on individual or subsets of anti-apoptotic proteins that could be effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2062c9229794d2b22c7358918295967
https://doi.org/10.1021/acs.jmedchem.9b01442
https://doi.org/10.1021/acs.jmedchem.9b01442
Publikováno v:
The Medical Journal of Cairo University. 87:3795-3799
Background: Nasal tip surgery is regarded as the most challenging aspect of plastic surgery. Control of nasal tip contour has always been a key component of a successful rhinoplasty. Creating a natural-appearing nasal tip contour is a complex task an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::174b75f816e6f9d7efcfc81b3508411c
https://doi.org/10.21608/mjcu.2019.69963
https://doi.org/10.21608/mjcu.2019.69963
Autor:
Meredith A. Morgan, Yuanyuan Ma, Zaneta Nikolovska-Coleska, Yi Sun, Qiang Zhang, Caila Ryan, Ahmed S.A. Mady, Theodore S. Lawrence
Publikováno v:
Nucleic Acids Research
FBXW7, a classic tumor suppressor, is a substrate recognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for ubiquitination and degradation. We recently found that FBXW7 is recruited to DNA damage sites to facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b63ebae3f408bc53cc27c5a05f0b13
https://doi.org/10.1093/nar/gkz058
https://doi.org/10.1093/nar/gkz058
Autor:
Miguel Rivera, Richard A. Sturm, Sophie Trefely, Peter Sajjakulnukit, Richard A. Scolyer, James S. Wilmott, Keith-Allen Melong, Sowmya Iyer, Costas A. Lyssiotis, Ho-Joon Lee, Min Wang, Andrei L. Osterman, Angela H. Guo, Surinder Kumar, Aleodor A. Andea, Ahmed Mostafa, H. Peter Soyer, Michelle Azar, Lauren Bringman-Rodenbarger, William Giblin, David B. Lombard, Zaneta Nikolovska-Coleska, Li Zhang, Douglas R. Fullen, Ahmed S.A. Mady, David Scott, Sriram Chandrasekaran, Mitchell S. Stark, Nathaniel W. Snyder, Carolina H Chung, Alexander C. Monovich, Marcus Bosenberg, Erika L. Varner, Antonia L. Pritchard, Namrata S Kadambi, Mary E. Skinner, Monique Verhaegen
Publikováno v:
J Clin Invest
Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13d947c0ca90c8e96d7f70e6c883f86
https://doi.org/10.1172/jci138926
https://doi.org/10.1172/jci138926
Autor:
Richard A. Sturm, William Giblin, Lauren Bringman-Rodenbarger, Keith-Allen Melong, Aleodor A. Andea, H. Peter Soyer, Min Wang, Erika L. Varner, Michelle Azar, Miguel Rivera, Nathaniel W. Snyder, Zaneta Nikolovska-Coleska, Li Zhang, Namrata S Kadambi, Richard A. Scolyer, Carolina H Chung, Douglas R. Fullen, Mary E. Skinner, Marcus Bosenberg, Monique Verhaegen, James S. Wilmott, Ho-Joon Lee, David B. Lombard, David Scott, Ahmed S.A. Mady, Antonia L. Pritchard, Mitchell S. Stark, Angela Guo, Sowmya Iyer, Costas A. Lyssiotis, Andrei L. Osterman, Surinder Kumar, Ahmed M. Mostafa, Sriram Chandrasekaran, Peter Sajjakulnukit, Sophie Trefely
Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7553fe2a39083e450b5f4478a02122b
https://doi.org/10.1101/2020.09.07.286526
https://doi.org/10.1101/2020.09.07.286526
Autor:
Tim J. Wigle, Luke Utley, Kevin Wayne Kuntz, Jeff Song, Jan-Rung Mo, W. David Church, Sunaina P. Nayak, Heike Keilhack, Yue Ren, Alvin Lu, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Christina R. Majer, Ahmed S.A. Mady, Melissa M. Vasbinder, Ellen Bamberg, Kerren Kalai Swinger, Bin Gui, Victoria M. Richon, Mario Niepel, Patricia E. Rao, Kristy Kuplast-Barr, Jennifer R. Molina, Timothy J. Mitchison, Joseph M. Gozgit, Elena Minissale, Zacharenia A. Varsamis
Publikováno v:
Cancer cell. 39(9)
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07edb791c59df419eedd1a9ffce03541
https://pubmed.ncbi.nlm.nih.gov/34375612
https://pubmed.ncbi.nlm.nih.gov/34375612
Autor:
Linda M. McAllister-Lucas, Peter C. Lucas, Zaneta Nikolovska-Coleska, Bill B. Chen, Heejae Kang, Dong Hu, Marcelo Murai, Ahmed S.A. Mady
Publikováno v:
Cancer Research. 80:3404-3404
The CARMA1/BCL10/MALT1 (CBM) signaling complex mediates antigen receptor-induced activation of NF-kB in lymphocytes to support normal adaptive immunity. As the effector protein of the complex, MALT1 exhibits two activities: protease and scaffolding a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709bcadafad30951b74873dff05ce74a
https://doi.org/10.1158/1538-7445.am2020-3404
https://doi.org/10.1158/1538-7445.am2020-3404
Autor:
Naval Bajwa, Karson J. Kump, Zaneta Nikolovska-Coleska, Haian Fu, Sierrah M. Grigsby, Lei Miao, Chenzhong Liao, Fardokht A. Abulwerdi, Ahmed S.A. Mady, Andrej Perdih, Yuhong Du, Katherine L. Lev, Jeanne A. Stuckey
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Protein-protein interactions (PPIs) represent important and promising therapeutic targets that are associated with the regulation of various molecular pathways, particularly in cancer. Although they were once considered “undruggable,” the recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded8e84110ffe04bb968ed5f992f8a94
http://europepmc.org/articles/PMC6033896
http://europepmc.org/articles/PMC6033896