Inhibition of activin-like kinase 4/5 attenuates cancer cachexia associated muscle wasting

Autor: S.A. Huisman, J. N. M. Ijzermans, Erik A.C. Wiemer, Gisela Ambagtsheer, M. G. van Vledder, R.W.F. de Bruin, S. van Damme-van Engel, Stef Levolger, J L A van Vugt

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, 9:9826. Nature Publishing Group
Scientific Reports

Cancer mediated activation of the ActRIIB-ALK4/5 heterodimer by myostatin is strongly associated with muscle wasting. We investigated in vitro and in vivo the efficacy of ALK4/5 receptor blockers SB431542 and GW788388 in preventing muscle wasting, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154fb5e41ad0d9ea4e611119e5de0759
http://link.springer.com/article/10.1038/s41598-019-46178-9