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Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo

Autor: Emmanuele A. Jannini, Silvia K. Nicolis, Simona Caporali, Valeriana Cesarini, Antonio Costanzo, Federica Todaro, Susanna Dolci, Rebecca Favaro, Pellegrino Rossi, Elisabetta Botti, P M Lacal, Eugenia Guida, V Tassinari, S Di Agostino

Publikováno v: Oncogene (Basingstoke) 36 (2017): 4508–4515. doi:10.1038/onc.2017.53
info:cnr-pdr/source/autori:Cesarini, V.; Guida, E.; Todaro, F.; Di Agostino, S.; Tassinari, V.; Nicolis, S.; Favaro, R.; Caporali, S.; Lacal, P. M.; Botti, E.; Costanzo, A.; Rossi, P.; Jannini, E. A.; Dolci, S./titolo:Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo/doi:10.1038%2Fonc.2017.53/rivista:Oncogene (Basingstoke)/anno:2017/pagina_da:4508/pagina_a:4515/intervallo_pagine:4508–4515/volume:36

Melanoma is a dangerous form of skin cancer derived from the malignant transformation of melanocytes. The transcription factor SOX2 is not expressed in melanocytes, however, it has been shown to be differentially expressed between benign nevi and mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fc57005c687d939c0f89577236eac6

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

Autor: Francesca Fausti, Sabrina Strano, Moshe Oren, Pamela Bielli, Giovanni Blandino, Pier Paolo Pandolfi, Marius Sudol, S Di Agostino, Mario Cioce, Claudio Sette

Publikováno v: Cell Death & Differentiation. 20:1498-1509

Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated protein (YAP protein), a major effector of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aec0e31264444ca5a3e2ec79471ff36
https://doi.org/10.1038/cdd.2013.101

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

Autor: Sara Donzelli, Giulia Fontemaggi, Sabrina Strano, Francesco Fazi, Francesca Biagioni, Paola Muti, Fabrizio Padula, S Di Agostino, Giovanni Blandino

Publikováno v: Cell Death & Differentiation. 19:1038-1048

p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogenic functions. Here we show that p53R175H,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a057b4209799af7927642f42ed51fa0
https://doi.org/10.1038/cdd.2011.190