Zobrazeno 1 - 10
of 359
pro vyhledávání: '"S. Zweifel"'
Autor:
Dipanwita Pati, Lisa R. Taxier, Mengfan Xia, Sophia I. Lee, Sara Y. Conley, Tori Sides, Kristen M. Boyt, Avery C. Hunker, Larry S. Zweifel, Thomas L. Kash
Publikováno v:
Addiction Neuroscience, Vol 11, Iss , Pp 100157- (2024)
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs are expresse
Externí odkaz:
https://doaj.org/article/bbb5fbfa91bd4021b419202c30ff7ee0
Autor:
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill
Publikováno v:
eLife, Vol 12 (2023)
Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity. Nevertheless, some studies have found no associati
Externí odkaz:
https://doaj.org/article/b90e4541469047cc97b6d050f23252f5
Autor:
Marcella M Cline, Barbara Juarez, Avery Hunker, Ernesto G Regiarto, Bryan Hariadi, Marta E Soden, Larry S Zweifel
Publikováno v:
eLife, Vol 12 (2023)
The axonal guidance cue netrin-1 serves a critical role in neural circuit development by promoting growth cone motility, axonal branching, and synaptogenesis. Within the adult mouse brain, expression of the gene encoding (Ntn1) is highly enriched in
Externí odkaz:
https://doaj.org/article/22ed1545a810479381a09300cbd9607a
Publikováno v:
Neurobiology of Stress, Vol 23, Iss , Pp 100527- (2023)
The anterior portion of the bed nucleus of the stria terminalis (BNST) modulates fear and stress responses. The anterodorsal BNST (adBNST) can be anatomically subdivided further into the lateral and medial divisions. Although output projections of BN
Externí odkaz:
https://doaj.org/article/75adfc267425433ea0cb722091f68203
Autor:
Jian Qiu, Martha A. Bosch, Todd L. Stincic, Avery C. Hunker, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101645- (2022)
Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic i
Externí odkaz:
https://doaj.org/article/6c8f4be480964addb3b17dc712cb716d
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
Neuropeptides play an important role in modulating mesolimbic system function. However, while synaptic inputs to the ventral tegmental area (VTA) have been extensively mapped, the sources of many neuropeptides are not well resolved. Here, we mapped t
Externí odkaz:
https://doaj.org/article/aa4d23b01d6148d4bec9a628cfbd5fbf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in t
Externí odkaz:
https://doaj.org/article/f50f1c98dcf546afbe56dc8a475cedea
Autor:
Mi-Seon Kong, Eun Joo Kim, Sanggeon Park, Larry S Zweifel, Yeowool Huh, Jeiwon Cho, Jeansok J Kim
Publikováno v:
eLife, Vol 10 (2021)
Animals seeking survival needs must be able to assess different locations of threats in their habitat. However, the neural integration of spatial and risk information essential for guiding goal-directed behavior remains poorly understood. Thus, we in
Externí odkaz:
https://doaj.org/article/5f5e8c16177048b2956b5deef11a569d
Autor:
Todd L. Stincic, Martha A. Bosch, Avery C. Hunker, Barbara Juarez, Ashley M. Connors, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101218- (2021)
Objective: Arcuate nucleus neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons drive ingestive behavior. The M-current, a subthreshold non-inactivating potassium current, plays a critical role in regulating NPY/AgRP neuronal excitability. Fastin
Externí odkaz:
https://doaj.org/article/fb095b3020044ae88ead4c1b4cac825f
Autor:
Avery C. Hunker, Larry S. Zweifel
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100070- (2020)
Summary: AAV-CRISPR/Cas9 permits gene mutagenesis in the adult CNS. Current methods determining in vivo on-target mutagenesis have been limited by the ability to isolate virally transduced cells. This protocol optimizes a workflow for the design, clo
Externí odkaz:
https://doaj.org/article/533d39031bb743c88221aa7400cfe729