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Akademický článek

Liver Assessment in Patients with Ataxia-Telangiectasia: Transient Elastography Detects Early Stages of Steatosis and Fibrosis

Autor: H. Donath, S. Wölke, V. Knop, U. Heß, R. P. Duecker, J. Trischler, T. Poynard, R. Schubert, S. Zielen

Publikováno v: Canadian Journal of Gastroenterology and Hepatology, Vol 2023 (2023)

Background. Ataxia-telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder characterized by pronounced cerebellar ataxia, telangiectasia, cancer predisposition, and altered body composition. Liver diseases with steatosis, fibrosis, an

Externí odkaz: https://doaj.org/article/7c25a7c1827645efb1a57b0378d8e864

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Akademický článek

Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial

Autor: M. Dreßler, D. Fussbroich, L. Böhler, E. Herrmann, N. Benker, M. Tytyk, J. Schulze, R. Schubert, C. Beermann, S. Zielen

Publikováno v: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-10 (2020)

Abstract Background Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsat

Externí odkaz: https://doaj.org/article/b0c0e6da070b42c2acb911ed71842467

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Akademický článek

A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma

Autor: D. Fussbroich, K. Zimmermann, A. Göpel, O. Eickmeier, J. Trischler, S. Zielen, R. Schubert, C. Beermann

Publikováno v: Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)

Abstract Background The immune-modulating potential of long-chain polyunsaturated fatty acids (LCPUFAs) based on their conversion into lipid mediators in inflammatory situations has been proven by several studies. Respecting the immune-modulative rol

Externí odkaz: https://doaj.org/article/cd023179155f48b2a369af19a0c443e8

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Akademický článek

Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans

Autor: S. P. Jerkic, F. Michel, H. Donath, E. Herrmann, R. Schubert, M. Rosewich, S. Zielen

Publikováno v: Mediators of Inflammation, Vol 2020 (2020)

Introduction. Bronchiolitis obliterans (BO) is a chronic disease in which persistent inflammation leads to obstruction and obliteration of the small airways. The aim of this study was to evaluate the value of calprotectin as an inflammatory marker in

Externí odkaz: https://doaj.org/article/eb6c75ca6c2d41778562cb52a7303206

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Akademický článek

Strong dose response after immunotherapy with PQ grass using conjunctival provocation testing

Autor: S. Zielen, P. Kuna, W. Aberer, S. Lassmann, O. Pfaar, L. Klimek, A. Wade, K. Kluehr, J. Raab, D. Wessiepe, D. Lee, M.F. Kramer, K. Gunawardena, T. Higenbottam, M.D. Heath, M.A. Skinner, P.J. de Kam

Publikováno v: World Allergy Organization Journal, Vol 12, Iss 11, Pp - (2019)

Background: Pollinex Quattro Grass (PQ Grass) is an effective, well-tolerated, short pre-seasonal subcutaneous immunotherapy to treat seasonal allergic rhinoconjunctivitis (SAR) due to grass pollen. In this Phase II study, 4 cumulative doses of PQ Gr

Externí odkaz: https://doaj.org/article/03d9e3b4b9304063ab7fa1346e39ca33

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Akademický článek

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