Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells

Autor: Jutta Meißner-Weigl, S. Zeck, Regina Ebert, Melanie Krug, Franz Jakob, Lorenz C. Hofbauer, Martina Rauner, Peggy Benisch, Andre F. Steinert

Publikováno v: Stem Cell Research, Vol 15, Iss 1, Pp 231-239 (2015)

The role of serum amyloid A (SAA) proteins, which are ligands for toll-like receptors, was analyzed in human bone marrow-derived mesenchymal stem cells (hMSCs) and their osteogenic offspring with a focus on senescence, differentiation and mineralizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0fd9fc1ab677f45c23ec6ccc8ed0e6
https://doi.org/10.1016/j.scr.2015.06.008

Selenium Supplementation Restores the Antioxidative Capacity and Prevents Cell Damage in Bone Marrow Stromal Cells In Vitro

Autor: Matthias Ulmer, Jutta Meissner-Weigl, Regina Ebert, Franz Jakob, Doris Schneider, Moustapha Kassem, Helga Stopper, S. Zeck, Nicole Schupp

Publikováno v: Ebert, R, Ulmer, M, Zeck, S, Meissner-Weigl, J, Schneider, D, Stopper, H, Schupp, N, Kassem, M & Jakob, F 2006, ' Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro ', Stem Cells, vol. 24, no. 5, pp. 1226-35 . https://doi.org/10.1634/stemcells.2005-0117

Bone marrow stromal cells (BMSCs) and other cell populations derived from mesenchymal precursors are developed for cell-based therapeutic strategies and undergo cellular stress during ex vivo procedures. Reactive oxygen species (ROS) of cellular and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408ed6e9a8f77e2e9e0613c58da85698
https://doi.org/10.1634/stemcells.2005-0117

Compound heterozygosity of two functional null mutations in the ALPL gene associated with deleterious neurological outcome in an infant with hypophosphatasia

Autor: J. Hamann, Stephanie Graser, Hermann J. Girschick, Franz Jakob, Steffen Kunzmann, Johannes G. Liese, Christine Hofmann, S. Zeck, Tobias Schwarz, K. Dietz, J. Nowak, Johannes Wirbelauer, Birgit Mentrup

Publikováno v: Bone. 55(1)

Hypophosphatasia (HPP) is a heterogeneous rare, inherited disorder of bone and mineral metabolism caused by different mutations in the ALPL gene encoding the isoenzyme, tissue-nonspecific alkaline phosphatase (TNAP). Prognosis is very poor in severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b1dcbb9bdeaa19aa98da1da5a7f9ae
https://pubmed.ncbi.nlm.nih.gov/23454488

The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors

Autor: Melanie Krug, Franz Jakob, Peggy Benisch, Sönke P. Frey, S. Zeck, Michael Amling, Tatjana Schilling, Regina Ebert, Ludger Klein-Hitpass, Thorsten Schinke, N. Raaijmakers, Martina Regensburger, Lothar Seefried

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45142 (2012)
PLoS ONE

Primary osteoporosis is an age-related disease characterized by an imbalance in bone homeostasis. While the resorptive aspect of the disease has been studied intensely, less is known about the anabolic part of the syndrome or presumptive deficiencies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9544dc938b0e380c5e96d1200b57c388
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-133379

Effects of high glucose on mesenchymal stem cell proliferation and differentiation

Autor: Jutta Meissner-Weigl, Norbert Schütze, Yu-Ming Li, Franz Jakob, Doris Schneider, Regina Ebert, Moustapha Kassem, Catarina Limbert, Tatjana Schilling, Peggy Benisch, Jochen Seufert, S. Zeck

Publikováno v: Li, Y-M, Schilling, T, Benisch, P, Zeck, S, Meissner-Weigl, J, Schneider, D, Limbert, C, Seufert, J, Kassem, M, Schütze, N, Jakob, F & Ebert, R 2007, ' Effects of high glucose on mesenchymal stem cell proliferation and differentiation ', Biochemical and Biophysical Research Communications, vol. 363, no. 1, pp. 209-215 . https://doi.org/10.1016/j.bbrc.2007.08.161

Udgivelsesdato: 2007-Nov-9 High glucose (HG) concentrations impair cellular functions and induce apoptosis. Exposition of mesenchymal stem cells (MSC) to HG was reported to reduce colony forming activity and induce premature senescence. We characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147f4ff4c16c69b209b7b3a760d77ca
https://pubmed.ncbi.nlm.nih.gov/17868648