Zobrazeno 1 - 5
of 5
pro vyhledávání: '"S. Y. Brendler"'
Publikováno v:
Carcinogenesis. 13:2435-2441
Toxicological mechanisms involved in organotropism of tumor induction may include cell-specific metabolic activation of the carcinogen, in vivo distribution of active metabolites and persistance of induced DNA damage. In order to elucidate which fact
Publikováno v:
Environmental and Molecular Mutagenesis. 15:24-35
This report focuses on the use of freshly isolated primary mammalian cells from different tissues and organs of the rat for the rapid and efficient analysis of toxic and genotoxic chemicals. The cells are either treated in vitro or they are isolated
Publikováno v:
Progress in clinical and biological research.
1. The in vitro studies showed that organ specific metabolic activation does not appear to play a predominant role for the in vivo activities of the studied nitrosamines 2. The in vivo studies following 1 h exposure of rats with the nitrosamines can
Publikováno v:
Environmental Hygiene II ISBN: 9783642467141
N-Nitrosodialkylamines are a unique class of environmental carcinogens which can cause tumors in rodents in a very organ specific manner. The mechanisms for these properties still await clarification. Possible involved parameters could be an organ sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12016f95f1c0b8912ec059245c0b46dd
https://doi.org/10.1007/978-3-642-46712-7_6
https://doi.org/10.1007/978-3-642-46712-7_6
Publikováno v:
Carcinogenesis. 9(7)
Short term in vivo studies were performed to study biological effects of the common air pollutants SO2 or NOx and their influence on the genotoxic activities of nitrosamines. Hepatocytes and lung cells were isolated from Sprague-Dawley rats which had