Zobrazeno 1 - 10
of 595
pro vyhledávání: '"S. Wold"'
Autor:
Seong-Su Han, Kuo-Kuang Wen, María L. García-Rubio, Marc S. Wold, Andrés Aguilera, Wojciech Niedzwiedz, Yatin M. Vyas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancer develops in Wiskott-Aldrich syndrome (WAS). Here the authors identify a role for WAS-protein (WASp) in the DNA stress-resolution pathway by promoting the function of Replication Protein A at replication forks after DNA damage.
Externí odkaz:
https://doaj.org/article/6e499727fe454b339e1196dece4c37d7
Autor:
Katrin Schaar, Anja Geisler, Milena Kraus, Sandra Pinkert, Markian Pryshliak, Jacqueline F. Spencer, Ann E. Tollefson, Baoling Ying, Jens Kurreck, William S. Wold, Robert Klopfleisch, Karoly Toth, Henry Fechner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 300-316 (2017)
Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that
Externí odkaz:
https://doaj.org/article/e97e24c9cc81475f96113129d27f1781
Publikováno v:
Journal of The Royal Society Interface. 20
Muscles act through elastic and dissipative elements to mediate movement, which can introduce dissipation and filtering which are important for energetics and control. The high power requirements of flapping flight can be reduced by an insect's exosk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a4f432eff6c33acfb5291eb1d8877d
https://doi.org/10.1098/rsif.2023.0141
https://doi.org/10.1098/rsif.2023.0141
Muscles act through elastic and dissipative elements to mediate movement, but these elements can introduce dissipation and filtering which are important for energetics and control. The high power requirements of flapping flight can be reduced by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6857b12f5fdb9a5b8fb07dfbdf5ee3e8
https://doi.org/10.1101/2022.12.27.522009
https://doi.org/10.1101/2022.12.27.522009
Publikováno v:
Biol Lett
Flying insects have elastic materials within their exoskeletons that could reduce the energetic cost of flight if their wingbeat frequency is matched to a mechanical resonance frequency. Flapping at resonance may be essential across flying insects be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f639c8e0c0ce4f46453da429eed2d
https://europepmc.org/articles/PMC9131119/
https://europepmc.org/articles/PMC9131119/
Autor:
Masayoshi Honda, Melchior Lauten, Marcus B. Valentine, Patrick Revy, Stéphane Coulon, Richa Sharma, Charnise Goodings, Caroline Kannengiesser, Fabian Beier, Melanie Boerries, Shondra M. Pruett-Miller, Sophie L Granger, Miriam Erlacher, Maria Spies, Axel Künstner, Megan A. Cooper, Jill A. Rosenfeld, Vincent Géli, Carole Saintomé, Victor B Pastor, Charlotte M. Niemeyer, Dmitri Churikov, Marcin W. Wlodarski, Sophia Polychronopoulou, Hauke Busch, Ti-Cheng Chang, Sandrine Hirschi, Louis Sanchez, Charikleia Kelaidi, Sushree S. Sahoo, Marc S. Wold, Alfonso G Fernandez, Sarah K. Nicholas
Publikováno v:
Blood
Blood, American Society of Hematology, 2021, ⟨10.1182/blood.2021011980⟩
Blood, 2021, ⟨10.1182/blood.2021011980⟩
Blood, 2022, 139 (7), pp.1039-1051. ⟨10.1182/blood.2021011980⟩
Blood, American Society of Hematology, 2021, ⟨10.1182/blood.2021011980⟩
Blood, 2021, ⟨10.1182/blood.2021011980⟩
Blood, 2022, 139 (7), pp.1039-1051. ⟨10.1182/blood.2021011980⟩
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are heterogeneous disorders caused by inherited loss-of-function mutations in telomere-associated genes. Here, we identify 3 germline heterozygous missense variants in the RPA1 gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d60362309a06fad91835f5abb3f0ae
https://hal.archives-ouvertes.fr/hal-03431979
https://hal.archives-ouvertes.fr/hal-03431979
Autor:
Nicole C McKnight, Yun Zhong, Mitchell S Wold, Shiaoching Gong, Greg R Phillips, Zhixun Dou, Yanxiang Zhao, Nathaniel Heintz, Wei-Xing Zong, Zhenyu Yue
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004626 (2014)
Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose dist
Externí odkaz:
https://doaj.org/article/51ac15d136a3420aa4e5c1812c95eb5b
Autor:
Sanjay Kumar Bharti, Lynda Bradley, Robert M. Brosh, Joshua A. Sommers, Keir C. Neuman, Irfan Khan, Sanket Awate, Marina A. Bellani, Kazuo Shin-ya, Graeme A. King, Koji Kobayashi, Yuliang Wu, Dana Branzei, Marc S. Wold, Takuye Abe, Yeonee Seol, Hiroyuki Kitao, Venkatasubramanian Vidhyasagar
Publikováno v:
Nucleic Acids Research
Fanconi Anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer. Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer. fancj−/− cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d6341d4f0e3bdc90a2bb28debbeb29
http://europepmc.org/articles/PMC6159516
http://europepmc.org/articles/PMC6159516
Publikováno v:
Trends in Cell Biology. 27:491-504
Previously thought of as a nonselective digestion process, autophagy is now known to specifically degrade aggregated proteins and damaged cellular organelles through the action of autophagy receptors, which provides cellular quality control and maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eaa9701910ec04207dc8be0c9ad852
https://doi.org/10.1016/j.tcb.2017.01.001
https://doi.org/10.1016/j.tcb.2017.01.001
RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells
Autor:
Hui Zhou, Zhiquan Wang, Mats Ljungman, Tamas Ordog, Marc S. Wold, Honglian Zhang, Zhiguo Zhang, Haiyun Gan, Jeong Heon Lee
Publikováno v:
Molecular Cell. 65:272-284
The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through a short hairpin RNA (shR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e49e483f792883248603c0982b1235
https://doi.org/10.1016/j.molcel.2016.11.030
https://doi.org/10.1016/j.molcel.2016.11.030