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(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

Autor: Henryk Barthel, Jörg Steinbach, Steffen Fischer, René Smits, Diego Cecchin, Osama Sabri, Bernhard Sattler, Marianne Patt, Solveig Tiepolt, Julia Luthardt, Georg-Alexander Becker, Alexander Hoepping, Gudrun Wagenknecht, Hermann-Josef Gertz, Michael Rullmann, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Peter Brust, S Wilke, Philipp Meyer, Swen Hesse

Publikováno v: European journal of nuclear medicine and molecular imaging 48(3), 731-746 (2021). doi:10.1007/s00259-020-05029-w
European Journal of Nuclear Medicine and Molecular Imaging

Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[18F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[18F]Flubatine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe5c48d1937d5e2d608c7de7a3b37fb
https://doi.org/10.1007/s00259-020-05029-w

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Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer’s dementia

Autor: Marianne Patt, Annegret Franke, Michael Rullmann, Julia Luthardt, Swen Hesse, Steffen Fischer, Osama Sabri, René Smits, Peter Schönknecht, Solveig Tiepolt, Georg-Alexander Becker, Alexander Hoepping, Bernhard Sattler, Gudrun Wagenknecht, Susanne Gräf, Ulrich Hegerl, S Wilke, Henryk Barthel, Peter Brust, Philipp Meyer, Winnie Deuther-Conrad

Publikováno v: Brain 141(6), 1840-1854 (2018). doi:10.1093/brain/awy099
Brain
Brain 141(2018)6, 1840-1854

Whether α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) expression is reduced in early Alzheimer’s disease is controversial. Using (-)-[18F]Flubatine PET, Sabri, Meyer et al. report α4β2-nAChR deficiency in mild Alzheimer’s dementia, esp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b184d2969e0987f260d59c686d23832
https://doi.org/10.1093/brain/awy099

Impact of APOE ε4 genotype on α4β2 nicotinic acetylcholine receptor availability in mild Alzheimer's dementia: a (-)-F-18-Flubatine PET study

Autor: Julia Luthardt, Bernhard Sattler, S Wilke, Swen Hesse, A Höpping, Henryk Barthel, PM Meyer, René Smits, Georg-Alexander Becker, Solveig Tiepolt, Winnie Deuther-Conrad, M Patt, Michael Rullmann, Peter Brust, Peter Schönknecht, Gudrun Wagenknecht, Osama Sabri

Publikováno v: 57. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::979bef2a5d5937d5eeddbbbeee94c21a
https://doi.org/10.1055/s-0039-1683487