Výsledky vyhledávání - "S. W. Sanders"

Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers

Autor: R H, Zobrist, B, Schmid, A, Feick, D, Quan, S W, Sanders

Publikováno v: Pharmaceutical research. 18(7)

To characterize the enantiomers of oxybutynin (OXY) and N-desethyloxybutynin (DEO) following transdermal and oral administration.OXY was administered either as a single transdermal system over a 96 h wear period or as a single 5 mg immediate-release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8fe9bc3e1384be054cf52cbdc32f8f3
https://pubmed.ncbi.nlm.nih.gov/11496941

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A short-term, multicenter, randomized double-blind dose titration study of the efficacy and anticholinergic side effects of transdermal compared to immediate release oral oxybutynin treatment of patients with urge urinary incontinence

Autor: G W, Davila, C A, Daugherty, S W, Sanders

Publikováno v: The Journal of urology. 166(1)

We compared the short-term efficacy, safety and tolerability of transdermal versus oral oxybutynin in adults with urge urinary incontinence.Volunteers with detrusor instability currently responding to oral immediate release oxybutynin were enrolled i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::129fa23033a7d1b4f0a781c7b522c181
https://pubmed.ncbi.nlm.nih.gov/11435844

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Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal system

Autor: A S, Dobs, P S, Bachorik, S, Arver, A W, Meikle, S W, Sanders, K E, Caramelli, N A, Mazer

Publikováno v: The Journal of clinical endocrinology and metabolism. 86(3)

Serum lipoproteins and cardiovascular risk are affected by endogenous and exogenous sex hormones. As part of a multicenter evaluation of a permeation-enhanced testosterone transdermal system (TTD), the interrelationships among serum lipoproteins, hor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff6711e1ca793e75370138a5cbba70e3
https://pubmed.ncbi.nlm.nih.gov/11238481

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Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system

Autor: S, Arver, A S, Dobs, A W, Meikle, R P, Allen, S W, Sanders, N A, Mazer

Publikováno v: The Journal of urology. 155(5)

The effects of androgen replacement via a nonscrotal permeation enhanced testosterone transdermal system on the sexual function of men with hypogonadism were assessed.An open label, multicenter study of testosterone supplementation and withdrawal was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3a275960d9b22cb849070849f4c3a7f
https://pubmed.ncbi.nlm.nih.gov/8627833

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The pharmacokinetics of recombinant human relaxin in nonpregnant women after intravenous, intravaginal, and intracervical administration

Autor: S A, Chen, A J, Perlman, N, Spanski, C M, Peterson, S W, Sanders, R, Jaffe, M, Martin, T, Yalcinkaya, R C, Cefalo, N C, Chescheir

Publikováno v: Pharmaceutical research. 10(6)

The pharmacokinetics of recombinant human relaxin (rhRlx) after intravenous (iv) bolus administration and the absorption of rhRlx after intracervical or intravaginal administration were determined in nonpregnant women. The study was conducted in two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8db90087a194e2527ddb8a0014244562
https://pubmed.ncbi.nlm.nih.gov/8257492

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Effect of a single dose of lactase on symptoms and expired hydrogen after lactose challenge in lactose-intolerant subjects

Autor: S W, Sanders, K G, Tolman, D P, Reitberg

Publikováno v: Clinical pharmacy. 11(6)

The effect of a single dose or oral lactase on symptoms, breath hydrogen concentration, and glucose absorption in lactose-intolerant subjects challenged with lactose was studied. Volunteers underwent a lactose challenge test; those whose breath hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c410d18dd96af0c60e0076abe456a28b
https://pubmed.ncbi.nlm.nih.gov/1534729

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Metabolism and disposition of clarithromycin in man

Autor: J L, Ferrero, B A, Bopp, K C, Marsh, S C, Quigley, M J, Johnson, D J, Anderson, J E, Lamm, K G, Tolman, S W, Sanders, J H, Cavanaugh

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(4)

The metabolic fate and pharmacokinetics of clarithromycin following a single 250- or 1200-mg oral dose of 14C-clarithromycin were studied in six healthy adult males. Peak plasma levels of clarithromycin averaged 0.6 microgram/ml after the low dose an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54cad9719885e9b1111a542918321648
https://pubmed.ncbi.nlm.nih.gov/1976065

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Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing

Autor: H. Jaeger, H. Mosberg, S. W. Sanders, N. Haering

Publikováno v: European Journal of Clinical Pharmacology. 30:331-334

Twenty-four healthy volunteers participated in a study on the disposition of ergotamine following oral and rectal administration. Plasma samples were collected surrounding each dose of medication and a new mass spectrometry method was used for quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8599e9ad805ed6f35c688f7f9a034690
https://doi.org/10.1007/bf00541538

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