Zobrazeno 1 - 10
of 22
pro vyhledávání: '"S. W. Rowlinson"'
Autor:
Michael J. Waters, Andrew Cotterill, S. W. Rowlinson, Kin Chuen Leung, N. J. Marshall, Jennifer E. Rowland, Ken K. Y. Ho
Publikováno v:
Clinical Endocrinology. 56:475-485
OBJECTIVE Because there is discordance between different immunoassay values for serum hGH, and because clinical state may not correlate with immunoreactive hGH, we have developed an assay to accurately measure serum hGH somatogenic bioactivity. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6168aa20c1d099943822ee2e16e94c
https://doi.org/10.1046/j.1365-2265.2002.01507.x
https://doi.org/10.1046/j.1365-2265.2002.01507.x
Autor:
Changmin Chen, Michael J. Waters, S. W. Rowlinson, Becky L. Conway-Campbell, Jennifer E. Rowland, Stuart N. Behncken
Publikováno v:
Letters in Peptide Science. 6:353-357
This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class 1 cytokine receptors. A variety of mutagenic analyses on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9753d73b6a6117a5622b54f372ff9855
https://doi.org/10.1007/bf02443432
https://doi.org/10.1007/bf02443432
Autor:
S. W. Rowlinson, Stuart N. Behncken, William R. Baumbach, Michael J. Waters, Richard W. E. Clarkson, Zida Wu, Christian J. Strasburger, Jennifer E. Rowland
Publikováno v:
Journal of Biological Chemistry. 273:5307-5314
Signal transduction by the growth hormone receptor (GHR) occurs through growth hormone (GH)-induced dimerization of two GHRs to form a trimeric complex. It is thought that dimerization alone is sufficient for signaling, since monoclonal antibodies (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79952d763b137d66ffefd353e6f538fa
https://doi.org/10.1074/jbc.273.9.5307
https://doi.org/10.1074/jbc.273.9.5307
Autor:
S. W. Rowlinson, Becky L. Conway-Campbell, Jennifer E. Rowland, Stuart N. Behncken, Michael J. Waters, Thea A. Monks
Publikováno v:
Journal of Biological Chemistry. 272:27077-27083
It has been known for more than 4 decades that only primate growth hormones are effective in primate species, but it is only with the availability of the 2.8 A structure of the human growth hormone (hGH).hGH-binding protein (hGHBP)2 complex that Souz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce0877bf90d3f6d6463be9a89b809c5
https://doi.org/10.1074/jbc.272.43.27077
https://doi.org/10.1074/jbc.272.43.27077
Autor:
Ross I. Brinkworth, Michael J. Waters, Stan Bastiras, Allan J. Robins, S. W. Rowlinson, Ross Barnard
Publikováno v:
Journal of Biological Chemistry. 270:16833-16839
Growth hormone (GH) is believed to signal by dimerizing its receptor through two binding sites on the hormone. Previous attempts to increase the biopotency of GH by increasing its site 1 affinity have been unsuccessful, which has led to a bias toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f94dd0ba4ce5e1f57c781054340ca0
https://doi.org/10.1074/jbc.270.28.16833
https://doi.org/10.1074/jbc.270.28.16833
Autor:
Carol Ruth Senn, Allan J. Robins, Michael J. Waters, Stan Bastiras, Julian R.E. Wells, Ross I. Brinkworth, S. W. Rowlinson, Ross Barnard
Publikováno v:
Biochemistry. 33:11724-11733
In this study we have demonstrated that the C-terminus of helix 1 of porcine GH (pGH) is a receptor-interactive region, thus extending the current binding site model of GH. This was achieved by introducing charge reversal mutations into this region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89426fe5d085d9da224b71315255a9f
https://doi.org/10.1021/bi00205a008
https://doi.org/10.1021/bi00205a008
Autor:
Michael J. Waters, S. Bastiras, Julian R.E. Wells, Allan J. Robins, S. W. Rowlinson, Ross Barnard, Ross I. Brinkworth
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcb4c70a4a9722528c2cfd77c570549
https://doi.org/10.1111/j.1651-2227.1994.tb13284.x
https://doi.org/10.1111/j.1651-2227.1994.tb13284.x
Publikováno v:
Scopus-Elsevier
Residues within the first disulphide loop of the GH receptor are highly conserved, and the two cysteines forming this motif are conserved across many cytokine receptors. We have used site-directed mutagenesis and the polymerase chain reaction with sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b0d6bb02e91640e4c199d208735108
https://doi.org/10.1677/jme.0.0090213
https://doi.org/10.1677/jme.0.0090213
Autor:
Shu-Hong Hu, Ulrika Rova, Christine L. Gee, Jennifer L. Martin, Judy Halliday, Alun Jones, David E. James, Nia J. Bryant, Catherine F. Latham, S. W. Rowlinson
Publikováno v:
Protein expression and purification. 31(2)
Two protein families that are critical for vesicle transport are the Syntaxin and Munc18/Sec1. families of proteins. These two molecules form a high affinity complex and play an essential role in vesicle docking and fusion. Munc18c was expressed as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69acdb3dbd172baec3b1a7cdd1ef828f
https://pubmed.ncbi.nlm.nih.gov/14550652
https://pubmed.ncbi.nlm.nih.gov/14550652
Publikováno v:
The Journal of biological chemistry. 275(9)
The two isoforms of cyclooxygenase, COX-1 and COX-2, are acetylated by aspirin at Ser-530 and Ser-516, respectively, in the cyclooxygenase active site. Acetylated COX-2 is essentially a lipoxygenase, making 15-(R)-hydroxyeicosatetraenoic acid (15-HET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a16d00677dd3ac38f40b585f20180f2
https://pubmed.ncbi.nlm.nih.gov/10692466
https://pubmed.ncbi.nlm.nih.gov/10692466