Zobrazeno 1 - 10
of 33
pro vyhledávání: '"S. W. Ellis"'
Autor:
Graham Ruecroft, Sophie Bergeron, Brian S. W. Ellis, Thomas Mahoney, Jonathan R. Knight, Karen Holt-Tiffin, David A. Chaplin, and Andrew P. Osborne, Catherine Hill, John H. Edwards
Publikováno v:
Organic Process Research & Development. 10:661-665
An efficient, scaleable synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate, a potential intermediate in the synthesis of Atorvastatin (Lipitor), has been developed. The three-stage process starts with reaction of low-cost epichlorohydrin with cyanide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0148104f1920338a10da1d9305ac69
https://doi.org/10.1021/op050257n
https://doi.org/10.1021/op050257n
Autor:
A. Tooley, J. L. Burn, S. W. Ellis, Geoffrey T. Tucker, J Boyle, Amin Rostami-Hodjegan, Z. E. Wilson
Publikováno v:
British Journal of Clinical Pharmacology. 56:433-440
Aims To determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of human liver and their interindividual variability. Methods Triplicate liver samples were used to determine values of MPPGL (n = 20) and HPGL (n = 7) after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e4a007adb9e7f23274f142d17f57d4
https://doi.org/10.1046/j.1365-2125.2003.01881.x
https://doi.org/10.1046/j.1365-2125.2003.01881.x
Autor:
Nicholas Seivewright, S. W. Ellis, Mohammad Zafar Iqbal, O. Lagundoye, Martin S. Lennard, Mohammad Reza Shiran, Joanna Chowdry, Geoffrey T. Tucker, Amin Rostami-Hodjegan
Publikováno v:
British Journal of Clinical Pharmacology. 56:220-224
Aims To assess CYP2D6 activity and genotype in a group of patients undergoing methadone maintenance treatment (MMT). Methods Blood samples from 34 MMT patients were genotyped by a polymerase chain reaction-based method, and results were compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293a9563cad577ffa1fbd08a01240465
https://doi.org/10.1046/j.1365-2125.2003.01851.x
https://doi.org/10.1046/j.1365-2125.2003.01851.x
Publikováno v:
Pharmacogenetics. 9:393-396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3d7f7fb89a29d9942c44d648906252
https://doi.org/10.1097/00008571-199906000-00015
https://doi.org/10.1097/00008571-199906000-00015
Autor:
S. W. Ellis
Publikováno v:
Journal of Intergenerational Relationships. 5:139-141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e05734d2e3bfa3b2387c56c3f28f6a14
https://doi.org/10.1300/j194v05n02_12
https://doi.org/10.1300/j194v05n02_12
Publikováno v:
Physical Review E. 57:4618-4621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27aae54f9c3b06ee110ced9e0dcc44d
https://doi.org/10.1103/physreve.57.4618
https://doi.org/10.1103/physreve.57.4618
Publikováno v:
Xenobiotica. 28:15-19
1. We describe the application of novel ab initio quantum mechanical methods to the study of ligand interactions with cytochrome P450cam (CYP101). 2. We find that our techniques accurately describe the transition from a low-spin state to a high-spin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc85ad7677e45dba359b1f86a3a1d715
https://doi.org/10.1080/004982598239713
https://doi.org/10.1080/004982598239713
Autor:
Eleni A. Rekka, S W Ellis, M. J. Ackland, Martin S. Lennard, Anthony P. Simula, C R Wolf, K Rowland, Geoffrey T. Tucker
Publikováno v:
Biochemical Journal. 316:647-654
Cytochrome P-450 2D6 (CYP2D6) is an important human drug-metabolizing enzyme responsible for the oxidation of more than 30 widely used therapeutic agents. The enzymes encoded by the published genomic [Kimura, Umeno, Skoda, Meyer and Gonzalez (1989) A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310c72a40149a61c9932abb885739842
https://doi.org/10.1042/bj3160647
https://doi.org/10.1042/bj3160647
Autor:
LE Ramsay, Wilfred W. Yeo, S W Ellis, I. G. Chadwick, Martin S. Lennard, K Rowland, I. U. Haq, Peter R. Jackson, Geoffrey T. Tucker
Publikováno v:
British Journal of Clinical Pharmacology. 38:9-14
1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bc6b436ed638f2ed4bd46740f51261
https://doi.org/10.1111/j.1365-2125.1994.tb04315.x
https://doi.org/10.1111/j.1365-2125.1994.tb04315.x
Autor:
Martin S. Lennard, L Y Lin, Geoffrey T. Tucker, A. Hiratsuka, Debra A. Schmitz, Arthur K. Cho, S W Ellis, HF Woods, T. Y. Y. Chu
Publikováno v:
Biochemical Pharmacology. 47:1151-1156
The metabolism of methylenedioxymethamphetamine (MDMA, “ecstasy”) was examined in a microsomal preparation of the yeast Saccharomyces cerevisiae expressing human debrisoquine hydroxylase, CYP2D6. Only one product, dihydroxymethylamphetamine (DHMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebba5b7095d5ddaf5b24b2e7856cbf4
https://doi.org/10.1016/0006-2952(94)90386-7
https://doi.org/10.1016/0006-2952(94)90386-7