Zobrazeno 1 - 3
of 3
pro vyhledávání: '"S. W J McPhee"'
Autor:
Paola Leone, E. O. Ong, K. Hyland, Andrew Freese, Jeremy S. Francis, S. W J McPhee, Christopher G. Janson, Srinivasa S. Raghavan, Tadao Serikawa
Publikováno v:
Molecular Brain Research. 135:112-121
The tremor rat is a spontaneous epilepsy model with a seizure phenotype caused by a deletion in the aspartoacylase (ASPA) gene. The absence of ASPA expression in these animals results in undetectable levels of enzyme activity and the accumulation of
Autor:
David Shera, John C. Haselgrove, Mitra Assadi, Dah Jyuu Wang, S. W J McPhee, Jeremy S. Francis, Andrew Freese, Christopher G. Janson, Larissa T. Bilaniuk, P. Hurh, Paola Leone
Publikováno v:
Neuropediatrics. 37(4)
Canavan disease is a childhood leukodystrophy caused by mutations in the gene for human aspartoacylase ( ASPA), which leads to an abnormal accumulation of the substrate molecule N-acetyl-aspartate (NAA) in the brain. This study was designed to model
Autor:
Richard Jude Samulski, S. W J McPhee
Publikováno v:
Gene Therapy. 16:707-708
Koch and colleagues (Circulation 2009; 113: 89)1 may have re-ignited the interest of cardiologists in gene therapy. They have shown a healthy, viable pipeline of therapeutics with data that shows a recovery strategy for heart failure.1 Their clinical