Zobrazeno 1 - 10
of 11
pro vyhledávání: '"S. V. Ponomartsev"'
Publikováno v:
Cell and Tissue Biology. 15:44-50
The ubiquitin-proteasome system is involved in the regulation of most major intracellular processes, and disruptions in the functioning of this system lead to various pathologies. The proteolytic core of this system, 20S proteasome, was found in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0b0436a9fa8c3ffba8777b63b3a61d
https://doi.org/10.1134/s1990519x2101003x
https://doi.org/10.1134/s1990519x2101003x
Autor:
I. B. Nazarov, S. V. Ponomartsev, E. V. Potapenko, N. D. Aksenov, Alexey Tomilin, Mikhail Gordeev, P. A. Dyban, Andrey A. Kuzmin, E. I. Bakhmet
Publikováno v:
Cell and Tissue Biology. 14:413-418
KH-domain PolyC-binding proteins perform many functions ranging from transcription regulation to alternative splicing. There are several evidences of their important role in embryogenesis and in embryonic stem cells (ESCs). ESCs are cultured counterp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14be5965fa8739b3ce9f37d2803f05b
https://doi.org/10.1134/s1990519x20060036
https://doi.org/10.1134/s1990519x20060036
Publikováno v:
Cellular and Molecular Life Sciences. 78:1207-1220
A novel approach in gene therapy was introduced 20 years ago since artificial non-integrative chromosome-based vectors containing gene loci size inserts were engineered. To date, different human artificial chromosomes (HAC) were generated with the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd52fad177972f9b587e043abf0897d8
https://doi.org/10.1007/s00018-020-03653-1
https://doi.org/10.1007/s00018-020-03653-1
Autor:
Mikhail Liskovykh, Alexey Tomilin, Natalay Kouprina, Vladimir Larionov, Alexandra M Kondrashkina, Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Ivan N Voropaev, Maria M Savina, Elena Kuzmina, S. V. Ponomartsev
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 879, p 879 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 879, p 879 (2020)
Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bfc728c897c5474ce591938b5aae38
Autor:
Veronika V. Ermakova, Alexey Tomilin, Elena V. Skvortsova, S. V. Ponomartsev, Sergey A. Sinenko, Andrey A. Kuzmin, T. Starkova, Olga A. Cherepanova
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2019)
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2019)
Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or inducible variants of these recombinases are expressed under the control of either lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b3b8a8d4c52ee69f2511d70ca72699
https://pubmed.ncbi.nlm.nih.gov/31843009
https://pubmed.ncbi.nlm.nih.gov/31843009
Publikováno v:
Experimental Cell Research. 389:111882
The gene therapy approach aiming at curing various human diseases began to develop as a technology from early eighties of the last century. To date the delivery of therapeutic genes are mainly mediated by virus-based, predominantly, non-integrated vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9057d64d9a856496cd6cd2b9c268ce8
https://doi.org/10.1016/j.yexcr.2020.111882
https://doi.org/10.1016/j.yexcr.2020.111882
Autor:
Vladimir Larionov, Alexey Tomilin, Natalia Alenina, Mikhail Liskovykh, Elena V. Skvortsova, S. V. Ponomartsev, Anna Malashicheva, Andrey A. Kuzmin, Natalay Kouprina, Aleksandr Khudiakov, Sergey A. Sinenko
Publikováno v:
Cells
Volume 7
Issue 12
Cells, Vol 7, Iss 12, p 261 (2018)
Volume 7
Issue 12
Cells, Vol 7, Iss 12, p 261 (2018)
AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b23c7a5399fadbb61d9ec88ce5dfb0
https://pubmed.ncbi.nlm.nih.gov/30544831
https://pubmed.ncbi.nlm.nih.gov/30544831
Autor:
Mikhail Liskovykh, Alexey Tomilin, A. P. Davydov-Sinitsyn, Rashida Orlova, S. A. Koshkin, Olga Bajenova, S. V. Ponomartsev, I. V. Rykov, E. N. Tolkunova
Publikováno v:
Cell and Tissue Biology. 9:318-325
Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3e8a2a6a28f366f1a5d404465ef45a
https://doi.org/10.1134/s1990519x15040045
https://doi.org/10.1134/s1990519x15040045
Autor:
Alexey Tomilin, Olga Bajenova, Mikhail Liskovykh, E. N. Tolkunova, S. V. Ponomartsev, A. P. Davydov-Sinitsyn, L. L. Chechik
Publikováno v:
Cell and Tissue Biology. 7:407-416
The present work is an attempt to compare cancer cells of the same origin but differing in the expression of CEA protein, a clinical marker of metastatic carcinomas. CEA, presumably, is one of the key factors in metastatic activity. We investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759a29a435ef2874a5e63926cc555783
https://doi.org/10.1134/s1990519x13050040
https://doi.org/10.1134/s1990519x13050040
Autor:
Natalay Kouprina, Mikhail Liskovykh, Elena Popova, Michael Bader, S. V. Ponomartsev, Vladimir Larionov, Natalia Alenina, Alexey Tomilin
Publikováno v:
Europe PubMed Central
De novo assembled alphoidtetO-type human artificial chromosomes (HACs) represent a novel promising generation of high capacity episomal vectors. Their function and persistence, and any adverse effects, in various cell types in live animals, have not,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f1539130d6bbb115b9161bfef34a51
