Zobrazeno 1 - 10
of 27
pro vyhledávání: '"S. V. Koval'tsova"'
Autor:
D V, Fedorov, S V, Koval'tsova, T A, Evstukhina, V T, Peshekhonov, A Iu, Chernenkov, V G, Korolev
Publikováno v:
Genetika. 49(3)
Previously, we isolated mutant yeasts Saccharomyces cerevisiae with an increased rate of spontaneous mutagenesis. Here, we studied the properties of HSM6 gene, the hsm6-1 mutation of which increased the frequency of UV-induced mutagenesis and decreas
Autor:
A Iu, Chernenkov, D V, Fedorov, L M, Gracheva, T A, Evstukhina, S V, Koval'tsova, V T, Peshekhonov, I V, Fedorova, V G, Korolev
Publikováno v:
Genetika. 48(3)
It was assumed previously that the mutator phenotype of the hms3 mutant was determined by processes taking place in the D-loop. As a next step, genetic analysis was performed to study the interactions between the hsm3 mutation and mutations of the ge
Autor:
A Iu, Chernenkov, L M, Gracheva, T A, Evstiukhina, S V, Koval'tsova, V T, Peshekhonov, I V, Fedorova, V G, Korolev
Publikováno v:
Genetika. 48(2)
In eukaryotes, damage tolerance of matrix DNA is mainly determined by the repair pathway under the control of the RAD6 epistatic group of genes. T this pathway is also a main source of mutations generated by mutagenic factors. The results of our rece
Autor:
A Iu, Chernenkov, S V, Ivanova, S V, Koval'tsova, L M, Gracheva, V T, Peshekhonov, I V, Fedorova, V G, Korolev
Publikováno v:
Genetika. 46(6)
Gene HSM3 encodes the Hsm3 protein involved in the minor branch in the system responsible for the correction of mismatched bases in DNA structure and controls replicative and reparative spontaneous mutagenesis in yeast Saccharomyces cerevisiae. Spont
Publikováno v:
Genetika. 46(6)
The yeast genes IXR1 and HMO1 encode proteins belonging to the family of chromatin nonhistone proteins, which are able to recognize and bind to irregular DNA structures. The full deletion of gene IXR1 leads to an increase in cell resistance to the le
Publikováno v:
Genetika. 44(11)
Geptrong is a medication from pure defermentated honey. In medical practice, it is used as hepatoprotector. Genotoxicity analysis revealed antimutagenic activity of the preparation. The spontaneous mutation rate at the ADE4-ADE8 and CAN1 loci was sev
Publikováno v:
Genetika. 43(1)
Sensitivity to the lethal action of the anticancer substance cisplatin was studied in the yeast mutants himl, hsm2, hsm3, and hsm6, deficient for repair of spontaneous and induced mutations. The himl and hsm3 mutants were as resistant to the agent un
Autor:
S V, Koval'tsova, L M, Gracheva, T A, Evstiukhina, I V, Fedorova, S Iu, Alekseev, V G, Korolev
Publikováno v:
Genetika. 32(8)
During recent years, genes controlling mutation in higher eukaryotes have been found to be involved actively in carcinoma regeneration in cells. In this respect, studying the genetic control of mutagenesis becomes a key direction of research into mec
Publikováno v:
Genetika. 32(7)
The interaction of six mutator genes of the yeast Saccharomyces cerevisiae with respect to UV-induced mutagenesis was studied. To this effect, double mutants with a genotype containing pairs of mutations at genes analyzed were synthesized. Analysis o
Publikováno v:
Genetika. 32(7)
During recent years, genes controlling mutation in higher eukaryotes have been found to be involved actively in carcinoma regeneration in cells. In this respect, studying the genetic control of mutagenesis becomes a key direction of research into mec