Zobrazeno 1 - 10 of 72 pro vyhledávání: '"S. Uitte De Willige"'
1
Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII
Autor: Frank W.G. Leebeek, Joyce J. M. C. Malfliet, S. Uitte de Willige, Shiraazkhan Abdul, Dingeman C. Rijken
Publikováno v: Journal of Thrombosis and Haemostasis, 14(7), 1453-1461. Wiley-Blackwell Publishing Ltd
textabstractEssentials Factor XIIIa inhibits fibrinolysis by forming fibrin-fibrin and fibrin-inhibitor cross-links. Conflicting studies about magnitude and mechanisms of inhibition have been reported. Factor XIIIa most strongly inhibits lysis of mec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d9e461704dc2ddcbaf4b50a7ff6045
https://doi.org/10.1111/jth.13354
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2
Increased N-terminal cleavage of alpha-2-antiplasmin in patients with liver cirrhosis
Autor: S. Uitte de Willige, Dingeman C. Rijken, Harry L.A. Janssen, Joyce J. M. C. Malfliet, Frank W.G. Leebeek
Publikováno v: Journal of Thrombosis and Haemostasis, 11(11), 2029-2036. Wiley-Blackwell Publishing Ltd
Summary Background The activity of alpha-2-antiplasmin (α2AP), the main fibrinolytic inhibitor, is modified by N- and C-terminal proteolytic cleavages. C-terminal cleavage converts plasminogen-binding α2AP (PB-α2AP) into a non-plasminogen-binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5238f13f72e226d272a063f1788501
https://hdl.handle.net/1765/74262
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4
Evidence that fibrinogen γ′ directly interferes with protofibril growth: implications for fibrin structure and clot stiffness
Autor: Robert A. S. Ariëns, Peter Allan, S. Uitte de Willige, Simon D. Connell, Radwa H. Abou-Saleh
Publikováno v: Journal of Thrombosis and Haemostasis. 10:1072-1080
Summary. Background: Fibrinogen contains an alternatively spliced γ-chain (γ′), which mainly exists as a heterodimer with the common γA-chain (γA/γ′). Fibrinogen γ′ has been reported to inhibit thrombin and modulate fibrin structure, but
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d81aa8d2889659194120f1fb6d7d72
https://doi.org/10.1111/j.1538-7836.2012.04717.x
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5
Selectin haplotypes and the risk of venous thrombosis: influence of linkage disequilibrium with the factor V Leiden mutation
Autor: F. R. Rosendaal, R M Bertina, S. Uitte De Willige, M. de Visser, H. L. Vos, Jeanine J. Houwing-Duistermaat
Publikováno v: Journal of Thrombosis and Haemostasis. 6:478-485
Summary. Background: Selectins (E-, L- and P-selectin) and their most important counter-receptor P-selectin glycoprotein ligand (SELPLG) facilitate the interaction of platelets, leukocytes and endothelial cells at inflammatory sites. Selectin polymor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f56182c81076bef40e971a35837872
https://doi.org/10.1111/j.1538-7836.2007.02879.x
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6
Polymorphism 10034C>T is located in a region regulating polyadenylation of FGG transcripts and influences the fibrinogen γ′/γA mRNA ratio
Autor: S. Uitte De Willige, M. de Visser, Rogier M. Bertina, Inge M. Rietveld, Hans L. Vos
Publikováno v: Journal of Thrombosis and Haemostasis. 5:1243-1249
Summary. Background: Fibrinogen gamma haplotype 2 (FGG-H2) is associated with reduced fibrinogen γ′ levels and fibrinogen γ′/total fibrinogen ratios and with an increased deep-venous thrombosis (DVT) risk. Two FGG-H2 tagging single nucleotide p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8795e35db0fa3a7de306c9d2550c510
https://doi.org/10.1111/j.1538-7836.2007.02566.x
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8
The fibrinogen γA/γ' isoform does not promote acute arterial thrombosis in mice
Autor: Todd M. Getz, Alisa S. Wolberg, Feng Chang Lin, S. Uitte de Willige, Wolfgang Bergmeier, B. L. Walton
Publikováno v: Journal of thrombosis and haemostasis : JTH. 12(5)
Summary Background Elevated plasma fibrinogen is associated with arterial thrombosis in humans and promotes thrombosis in mice by increasing fibrin formation and thrombus fibrin content. Fibrinogen is composed of six polypeptide chains: (Aα, Bβ, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894524f20faa6d78fd3506a6209fd2bc
https://pubmed.ncbi.nlm.nih.gov/24916154
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9
Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ'
Autor: Farida Omarova, Rogier M. Bertina, Elisabetta Castoldi, S. Uitte de Willige, Robert A. S. Ariëns, Jan Rosing
Publikováno v: Journal of Thrombosis and Haemostasis, 11(9), 1669-1678. Wiley
Journal of Thrombosis and Haemostasis, 11(9), 1669-1678. Wiley-Blackwell Publishing Ltd
Summary Background Besides its role in blood clotting, fibrinogen exerts a poorly understood anticoagulant function by binding thrombin and modulating its activity. In particular, the γA/γ′ fibrinogen isoform binds with high affinity to thrombin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d21c7abb2e973b36e352effa995af0
https://pubmed.ncbi.nlm.nih.gov/23848367
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10
Binding of carboxypeptidase N to fibrinogen and fibrin
Autor: Simone Talens, S. Uitte De Willige, Frank W.G. Leebeek, Joyce Malfliet, Jeroen Demmers, Dingeman C. Rijken, Joyce H.G. Lebbink
Publikováno v: Biochemical & Biophysical Research Communications, 427(2), 421-425. Academic Press
The ultimate step in the blood coagulation cascade is the formation of fibrin. Several proteins are known to bind to fibrin and may thereby change clot properties or clot function. Our previous studies identified carboxypeptidase N (CPN) as a novel p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f25ada82fe07ed49b11cd8b61ae8feb
https://pubmed.ncbi.nlm.nih.gov/23000409
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