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Akademický článek

Beliefs surrounding the use of inhaled asthma medication in The Gambia: a qualitative study of asthma patients and healthcare workers

Autor: S. Jayasooriya, M. Inoue, H. Allen, M. Bojang, A. Ceesay, S. Touray, R. Cooper, K. Mortimer, J. Balen

Publikováno v: npj Primary Care Respiratory Medicine, Vol 34, Iss 1, Pp 1-6 (2024)

Abstract Asthma-related mortality is high in low- and middle-income countries. Little is known about public perceptions of inhaled medicines. We conducted semi-structured interviews with asthma patients and healthcare workers at three secondary care

Externí odkaz: https://doaj.org/article/ffd7e2e5fb47434da40c043e2fb87009

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Akademický článek

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Akademický článek

Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants.

Autor: Beth Holder, David J C Miles, Steve Kaye, Sarah Crozier, Nuredin Ibrahim Mohammed, Nancy O Duah, Elishia Roberts, Olubukola Ojuola, Melba S Palmero, Ebrima S Touray, Pauline Waight, Matthew Cotten, Sarah Rowland-Jones, Marianne van der Sande, Hilton Whittle

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14013 (2010)

BACKGROUND:Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccine

Externí odkaz: https://doaj.org/article/0e3c5922156b48968c9356a73f79aba5

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Akademický článek

Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants.

Autor: David J C Miles, Marianne van der Sande, David Jeffries, Steve Kaye, Olubukola Ojuola, Mariama Sanneh, Momodou Cox, Melba S Palmero, Ebrima S Touray, Pauline Waight, Sarah Rowland-Jones, Hilton Whittle, Arnaud Marchant

Publikováno v: PLoS ONE, Vol 3, Iss 8, p e2905 (2008)

In a previously published study, we found that large differentiated subpopulations of CD8 T-cells emerged rapidly after CMV infection in young infants and persisted throughout the following year. Here we describe a follow-up study conducted on the sa

Externí odkaz: https://doaj.org/article/94e1dbf0e3ac4e15baea18b47e1aca42

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Enhancement of cytokine‐driven NK cell IFN‐γ production after vaccination of HCMV infected Africans

Autor: Martin R. Goodier, Ed Clarke, Alansana Darboe, Ebrima Danso, Rita Wegmüller, Ebrima S. Touray, Ama Umesi, Eleanor M. Riley, Sophie E. Moore

Publikováno v: European Journal of Immunology
Darboe, A, Danso, E, Clarke, E, Umesi, A, Touray, E, Wegmuller, R, Moore, S E, Riley, E M & Goodier, M R 2017, ' Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans ', European Journal of Immunology, vol. 47, no. 6, pp. 1040-1050 . https://doi.org/10.1002/eji.201746974

Human cytomegalovirus (HCMV) infection drives the phenotypic and functional differentiation of NK cells, thereby influencing the responses of these cells after vaccination. NK cell functional differentiation is particularly advanced in African popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a6084cd8c8517e6842d78b6177e6be
http://europepmc.org/articles/PMC5888140

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Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years

Autor: Assan Jaye, Marianne A B van der Sande, David Miles, Samuel Nyamweya, Katie L. Flanagan, Jane U. Adetifa, David Jeffries, Sarah Rowland-Jones, Safayet Hossin, Syed M. A. Zaman, Melba S. Palmero, Hilton Whittle, Jainaba Njie-Jobe, Ebrima S. Touray, Sarah Burl

Publikováno v: Vaccine

Highlights ► Gambian infants were given one or two doses of measles vaccine. ► The kinetics of the immune response was compared after a boost. ► Antibody responses were equally rapid and high. ► Cell mediated responses were insignificantly di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18bf7b34ff7b81866fffabae5432e48
https://doi.org/10.1016/j.vaccine.2012.01.083

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Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants

Autor: Melba S. Palmero, Samuel Nyamweya, Syed M. A. Zaman, Sarah Rowland-Jones, Ebrima S. Touray, Beth Holder, David Miles, Mariama Sanneh, Marianne A B van der Sande, Hilton Whittle, Sarah Crozier

Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T-cell differentiation in Gambian infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7944db0d9d31f7bb4019bcb2931b406
https://doi.org/10.1111/j.1365-2567.2007.02787.x

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Effects of Antenatal and Postnatal Environments on CD4 T-Cell Responses toMycobacterium bovisBCG in Healthy Infants in The Gambia

Autor: Martin O. C. Ota, Sarah Rowland-Jones, Olubukola Ojuola, Arnaud Marchant, Melba S. Palmero, Mariama Sanneh, Ebrima S. Touray, Hilton Whittle, Sarah Crozier, Marianne A B van der Sande, David Miles

Publikováno v: Clinical and Vaccine Immunology. 15:995-1002

TheMycobacterium bovisBCG vaccine has a poor record of efficacy in low-income tropical settings. Against this background, we evaluated the immune response of infants to mycobacterial antigens over the 2 years following BCG vaccination at birth by mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22928d0bda663af82a298e2b41a0eb45
https://doi.org/10.1128/cvi.00037-08

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