Výsledky vyhledávání

Generation and characterization of a monoclonal antibody to the cytoplasmic tail of MUC16

Autor: Balaraj B. Menon, Henrik Clausen, Ulla Mandel, Ann S. Tisdale, Diana Campos, Sandra Michaud, Ilene K. Gipson

Publikováno v: Glycobiology. 27:920-926

MUC16 is a large transmembrane mucin expressed on the apical surfaces of the epithelium covering the ocular surface, respiratory system and female reproductive tract. The transmembrane mucin is overexpressed by ovarian carcinomas, it is one of the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb5e72676141fdaae385ca420d6b2b9
https://doi.org/10.1093/glycob/cwx054

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Refractive surgery in the HIV-positive U.S. Military Natural History Study Cohort: complications and risk factors

Autor: Carter S, Tisdale, Grant A, Justin, Xun, Wang, Xiuping, Chu, Darrel K, Carlton, Jason F, Okulicz, Christina, Schofield, Ryan C, Maves, Brian K, Agan, Gary L, Legault, M, Stein

Publikováno v: J Cataract Refract Surg

Purpose This study sought to assess the frequency of refractive surgery complications in HIV+ individuals and related risk factors. Settings Multiple centers in the United States. Design Prospective observational cohort study. Methods The U.S. Milita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81370dba44a875356b202640a5c37510
https://pubmed.ncbi.nlm.nih.gov/31585850

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Human conjunctival goblet cells express the membrane associated mucin MUC16: Localization to mucin granules

Autor: Ilene K. Gipson, Sandra Spurr-Michaud, Ann S. Tisdale

Publikováno v: Experimental Eye Research. 145:230-234

MUC16 is an extraordinarily large 22,152 amino acid membrane spanning mucin that has been shown to be present in the glycocalyx of the apical cells of the human cornea and conjunctiva where it interfaces with the tear film. The ectodomain of the mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1595343442b522743aef7d869bebf97
https://doi.org/10.1016/j.exer.2015.12.009

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Suppression of Toll-like Receptor-Mediated Innate Immune Responses at the Ocular Surface by the Membrane-associated Mucins MUC1 and MUC16

Autor: Balaraj B. Menon, Christina Kaiser-Marko, Ilene K. Gipson, Ann S. Tisdale, Sandra Spurr-Michaud

Publikováno v: Mucosal immunology

Membrane-associated mucins (MAMs) expressed on the ocular surface epithelium form a dense glycocalyx that is hypothesized to protect the cornea and conjunctiva from external insult. In this study, the hypothesis that the MAMs MUC1 and MUC16, expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef90f2a8b1750bf88a2b444e0b358761
http://europepmc.org/articles/PMC4495011

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List of Contributors

Autor: E.J. Androphy, W.D. Arnold, C.E. Beattie, T. Bordet, P.J. Boyd, A.H.M. Burghes, M.E.R. Butchbach, A.N. Calder, K.S. Chen, J.J. Cherry, S.P. Corti, T.O. Crawford, B.T. Darras, D.C. De Vivo, M.O. Deguise, C.J. DiDonato, G. Dreyfuss, V. Dubowitz, A.D. Ebert, I. Faravelli, R.S. Finkel, K.H. Fischbeck, E.V. Fletcher, K.D. Foust, E.L. Garcia, T.H. Gillingwater, D. Hammers, L.T. Hao, A.C. Hart, K.J. Hodgetts, M.D. Howell, Y. Hua, S.T. Iannaccone, J. Jarecki, B.K. Kaspar, S.J. Kolb, L. Kong, R. Kothary, A.R. Krainer, V. Le Verche, C.L. Lorson, C.M. Lutz, A. MacKenzie, A.G. Matera, E.S. Mazzone, V.L. McGovern, J. Melki, N. Mendoza-Ferreira, G.Z. Mentis, E. Mercuri, S. Messina, U.R. Monani, J. Montes, L.L. Nelson, S.Y. Ng, P. O’Hern, M.A. Osborne, M. Oskoui, T.N. Patitucci, S. Paushkin, L. Pellizzoni, M.J. Pérez-García, T.W. Prior, R.M. Pruss, L.L. Rubin, S.B. Rutkove, M.K. Schroth, L.R. Simard, N.N. Singh, R.N. Singh, B.R. So, C.J. Sumner, S.S. Sunshine, H.L. Sweeney, S. Tisdale, E.F. Tizzano, L. Torres-Benito, B. Wirth, Z. Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd3d168b16bebfdc9ac46060924e05fe
https://doi.org/10.1016/b978-0-12-803685-3.01002-8

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MUC16 Is Lost from the Uterodome (Pinopode) Surface of the Receptive Human Endometrium: In Vitro Evidence That MUC16 Is a Barrier to Trophoblast Adherence1

Autor: Ilene K. Gipson, Kristina Gemzell, Sara Allcorn, Ann S. Tisdale, Timothy D. Blalock, Sandra Spurr-Michaud, Anneli Stavreus-Evers

Publikováno v: Biology of Reproduction. 78:134-142

In order for the preimplantation embryo to implant into the uterus, the trophoblast cells must initially adhere to the uterine epithelial surface. In preparation, the luminal secretory cells of the epithelium lose their nonadhesive character and thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edcacc2a3fcbc9e307916f90968b5c35
https://doi.org/10.1095/biolreprod.106.058347

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Mucin gene expression is not regulated by estrogen and/or progesterone in the ocular surface epithelia of mice

Autor: Sandra Spurr-Michaud, Jolene Fernandez, Christine Lange, David J Shim, Ann S. Tisdale, Ilene K. Gipson

Publikováno v: Experimental Eye Research. 77:59-68

Purpose. Dry eye syndrome is prevalent in post-menopausal women, and post-menopausal women secrete less mucus in their reproductive tracts. Using a mouse model, the purpose of this study was to determine if estrogen and/or progesterone regulates Muc4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6becc00db8518dc8b5f029ba5da77fe
https://doi.org/10.1016/s0014-4835(03)00064-2

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Variation in the Amount of T Antigen andN-Acetyllactosamine Oligosaccharides in Human Cervical Mucus Secretions with the Menstrual Cycle

Autor: Ann S. Tisdale, Pablo Argüeso, Ilene K. Gipson, Sandra Spurr-Michaud

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 87:5641-5648

It has been hypothesized that the carbohydrate portion of mucins present in the endocervical canal plays an important role in conferring specific physicochemical properties (e.g. viscosity and hydration) to the mucus gel through the menstrual cycle.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf1b1f8bfbe938ed00bb2c4c6f5b1d6
https://doi.org/10.1210/jc.2002-020766

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Comparison of the transmembrane mucins MUC1 and MUC16 in epithelial barrier function

Autor: Ilene K. Gipson, Balaraj B. Menon, Ann S. Tisdale, Sandra Spurr-Michaud

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e100393 (2014)

Membrane-anchored mucins are present in the apical surface glycocalyx of mucosal epithelial cells, each mucosal epithelium having at least two of the mucins. The mucins have been ascribed barrier functions, but direct comparisons of their functions w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caebbc81cce3551fea5fbb60127fb418
https://pubmed.ncbi.nlm.nih.gov/24968021

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