Zobrazeno 1 - 10
of 100
pro vyhledávání: '"S. Theile"'
Autor:
Dhrubajyoti Datta, Christopher S. Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M. Janas, Martin Egli, Muthiah Manoharan
Publikováno v:
Chemical Communications. 59:6347-6350
A new class of 5′-morpholino modified nucleoside building blocks was synthesized. Among them, Mo2 exhibited better off-target mitigation for RNAi compared to other analogues Pip and Mo3 and the previously reported morpholino derivative Mo1.
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Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Autor:
Vadim Dudkin, Muthiah Manoharan, Karyn O'neil, Vasant Jadhav, Jeannine Mendrola Zarazowski, Laura Sepp-Lorenzino, Rubina G. Parmar, Shalom Goldberg, Richard Dambra, Donna Klein, Elise Kuhar, Mark Richter, Christopher S. Theile, Martin Maier, Tricia Lin, Kathleen Haskell, Meizhen Wu
Publikováno v:
Molecular Therapy. 29:2053-2066
RNA interference (RNAi) offers the potential to treat disease at the earliest onset by selectively turning off the expression of target genes, such as intracellular oncogenes that drive cancer growth. However, the development of RNAi therapeutics as
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Autor:
Ryan Malone, Christopher S. Theile, Scott Lentini, Muthusamy Jayaraman, Mikyung Yu, Varun Goel, Rubina G. Parmar, Vasant Jadhav, Shigeo Matsuda, Mark K Schlegel, Guo He, Dennis Brown, June Qin, Swati Gupta, Timothy Racie, Svetlana Shulga-Morskaya, Anil V. Nair, Muthiah Manoharan, Jayaprakash K. Nair, Karyn Schmidt, Azar Shahraz, Ivan Zlatev, Christopher R. Brown, Martin Maier
Publikováno v:
Nucleic Acids Research
One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans. Here, we investigated the underlying biology supporting this extended
Autor:
T.D. Christensen, E. Maag, S. Theile, K. Madsen, S.C. Lindgaard, D.L. Nielsen, I. Chen, J.S. Johansen
Publikováno v:
Immuno-Oncology and Technology. 16:100134
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Benny Vittrup Jensen, Dorte Nielsen, S. Theile, K. S. Simonsen, P. Grundtvig, Rikke Løvendahl Eefsen, Louise Laurberg Klarskov, D. Høgdall, Estrid Høgdall, T. Lorentzen, Inna Chen, T. S. Poulsen
Publikováno v:
Acta oncologica (Stockholm, Sweden). 60(12)
BACKGROUND Metastatic colorectal cancer (mCRC) is a complex and heterogeneous disease with few standard and targeted treatment options. Next-generation sequencing of tumor tissue was performed to identify cancer driver mutations to discover possible