The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye

Autor: Hongsu Wang, Carolyn A. Morrison, Neha Ghosh, Joy S. Tea, Gerald B. Call, Jessica E. Treisman

Publikováno v: Development

The formation of a functional organ such as the eye requires specification of the correct cell types and their terminal differentiation into cells with the appropriate morphologies and functions. Here, we show that the zinc-finger transcription facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e319913665c1bf659989a563080aaf
https://europepmc.org/articles/PMC8995086/

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

Autor: Joy S. Tea, Oded Foreman, Sara L. Dominguez, Hai Ngu, Amy Easton, Timothy K. Earr, Robert Brendza, Jose Imperio, Baris Bingol, Joshua D. Webster, Domagoj Vucic, Kim Stark, Eugene Varfolomeev

Publikováno v: Cell Death Differ

RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6202ba1019dfe8ee4603903ffbfaa17
https://pubmed.ncbi.nlm.nih.gov/32994544

Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

Autor: Kelly Mousa, Urbano Anido Herranz, Mark Linch, Bernadett Szabados, Aaron Prendergast, Joy S. Tea, Alejo Rodriguez-Vida, Diana Stanoeva, Andrew Protheroe, Romain Banchereau, Thomas Powles, Mark M. Kockx, Daniel Castellano, Cristina Suarez, Alain Ravaud, Peter A. van Dam, Albert Font Pous, Ignacio Duran, Simon J. Crabb, Maria Jose Mendez, Gwenaelle Gravis, Denis Maillet, Sanjeev Mariathasan, Sofie Daelemans, Michiel S. van der Heijden

Publikováno v: Nature medicine
Nature Medicine
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Nature medicine, 25(11), 1706-1714. Nature Publishing Group

Antibodies targeting PD-1 or its ligand 1 PD-L1 such as atezolizumab, have great efficacy in a proportion of metastatic urothelial cancers1,2. Biomarkers may facilitate identification of these responding tumors3. Neoadjuvant use of these agents is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3da40d2b0015d913e30676ceb061b35
https://hdl.handle.net/10668/14633

Apport du bilan des anomalies de la coagulation et de la fibrinolyse dans les occlusions de la veine centrale de la rétine chez les sujets de moins de 60ans

Autor: S. Tea, M. Barrali, Bernard Delbosc, E. Racadot

Publikováno v: Journal Français d'Ophtalmologie. 36:5-11

Resume Objectif Evaluer l’interet du bilan des facteurs de la coagulation et de la fibrinolyse chez les sujets de moins de 60 ans ayant une occlusion de la veine centrale de la retine (OVCR). Patients et methode Etude observationnelle et prospectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42b542877822e936bafcb98d7f1f4875
https://doi.org/10.1016/j.jfo.2012.06.017

Dissection and Mounting of Drosophila Pupal Eye Discs

Autor: Albert Cespedes, Joy S. Tea, Gerald B. Call, Utpal Banerjee, Daniel Dawson

Publikováno v: Journal of Visualized Experiments.

The Drosophila melanogaster eye disc is a powerful system that can be used to study many different biological processes. It contains approximately 800 separate eye units, termed ommatidia1. Each ommatidium contains eight neuronal photoreceptors that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482153f5097475ab7184cf8a5bb7bdb4
https://doi.org/10.3791/52315-v