Zobrazeno 1 - 10
of 32
pro vyhledávání: '"S. Tamir Rashid"'
Autor:
Tiziano Mazza, Theodoros I. Roumeliotis, Elena Garitta, David Drew, S. Tamir Rashid, Cesare Indiveri, Jyoti S. Choudhary, Kenneth J. Linton, Konstantinos Beis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. MRP2 dysfunction, in Dubin-Johnson syndrome or by off-target inhibition, for example
Externí odkaz:
https://doaj.org/article/fdd5bced4bd2462399776434cd49d9e5
Autor:
Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N. Mayhew, Jennifer Hellmann, Alexander Miethke, Nahrin L. Tasnova, Samuel J.I. Blackford, Zu Ming Tang, Adam M. Syanda, Liang Ma, Fang Xiao, Melissa Sambrotta, Oliver Tavabie, Filipa Soares, Oliver Baker, Davide Danovi, Hisamitsu Hayashi, Richard J. Thompson, S. Tamir Rashid, Akihiro Asai
Publikováno v:
JHEP Reports, Vol 4, Iss 4, Pp 100446- (2022)
Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for the liver pa
Externí odkaz:
https://doaj.org/article/a3897953261242379e6856ff67f6e514
Autor:
Adam M. Syanda, Vera I. Kringstad, Samuel J. I. Blackford, Joachim S. Kjesbu, Soon Seng Ng, Liang Ma, Fang Xiao, Abba E. Coron, Anne Mari A. Rokstad, Sunil Modi, S. Tamir Rashid, Berit Løkensgard Strand
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Intra-peritoneal placement of alginate encapsulated human induced pluripotent stem cell-derived hepatocytes (hPSC-Heps) represents a potential new bridging therapy for acute liver failure. One of the rate-limiting steps that needs to be overcome to m
Externí odkaz:
https://doaj.org/article/f457da41d2f843768b7ad1d228d8561c
Autor:
Joe M. Segal, Deniz Kent, Daniel J. Wesche, Soon Seng Ng, Maria Serra, Bénédicte Oulès, Gozde Kar, Guy Emerton, Samuel J. I. Blackford, Spyros Darmanis, Rosa Miquel, Tu Vinh Luong, Ryo Yamamoto, Andrew Bonham, Wayel Jassem, Nigel Heaton, Alessandra Vigilante, Aileen King, Rocio Sancho, Sarah Teichmann, Stephen R. Quake, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of c
Externí odkaz:
https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
Autor:
John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 693-702 (2018)
Summary: Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap. Using image-ba
Externí odkaz:
https://doaj.org/article/7c1f980085ad4d33ad10a8f4d8dd7616
Autor:
Samuel J.I. Blackford, Tracy T.L. Yu, Michael D.A. Norman, Adam M. Syanda, Michail Manolakakis, Dariusz Lachowski, Ziqian Yan, Yunzhe Guo, Elena Garitta, Federica Riccio, Geraldine M. Jowett, Soon Seng Ng, Santiago Vernia, Armando E. del Río Hernández, Eileen Gentleman, S. Tamir Rashid
Publikováno v:
Gentleman, E, Rashid, T, Blackford, S, Jowett, G, Yan, Z, Yu, T, Norman, M, Guo, Y, Syanda, A, Riccio, F, Ng, S S, Manolakakis, M, Lachowski, D, Garrita, E, Vernia, S & de Rio Hernandez, A 2023, ' RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling ', Biomaterials, vol. 293, 121982 . https://doi.org/10.1016/j.biomaterials.2022.121982
Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised that replicating healthy liver niche biochemical and biophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d9ea300a57246addd8c417a8dad89a
http://hdl.handle.net/10044/1/102659
http://hdl.handle.net/10044/1/102659
Autor:
Deniz Kent, Soon Seng Ng, Payam Khoshkenar, Adam Syanda, Chao Zheng Li, Marina Zieger, Stephanie Hatch, Joe Segal, Samuel Blackford, Kaixing Le, Vivek Chowdary, Taylor Ismaili, Davide Danovi, Patrick Lewis, Sunil Sahdeo, Daniel Ebner, Christian Mueller, S. Tamir Rashid
Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by inheritance of the SERPINA1-Z genetic variant (PiZ) leading to protein misfolding and liver toxicity. There remain no approved medicines for this disease. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8daaf1f53f7f2962db34f88649f13a
https://doi.org/10.21203/rs.3.rs-1283764/v1
https://doi.org/10.21203/rs.3.rs-1283764/v1
Autor:
Pearlyn Jia Ying Toh, Yue Zhang, Cornelia Monzel, S. Tamir Rashid, Vidhyalakshmi Acharya, Hanry Yu, Virgile Viasnoff, Jasmine Fei Li Chin, Noémi van Hul, Inn Chuan Ng, Richard De Mets, Soon Seng Ng
Publikováno v:
Nature Materials. 19:1026-1035
The symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for the development of apicobasal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells collectiv
Autor:
Bibek Gooptu, Adam Redzej, Ibrahim Aldobiyan, Elena V. Orlova, David H. Adams, James A. Irving, S. Tamir Rashid, Nina Heyer-Chauhan, Gary M. Reynolds, Magd Badaoui, Alistair M. Jagger, Sarah V. Faull, Emma L. K. Elliston, Elena Miranda, David A. Lomas
Publikováno v:
'Science Advances ', vol: 6, pages: eabc1370-1-eabc1370-15 (2020)
Science Advances
Science advances 6(43), eabc1370 (1-14) (2020). doi:10.1126/sciadv.abc1370
Science Advances
Science advances 6(43), eabc1370 (1-14) (2020). doi:10.1126/sciadv.abc1370
Science advances 6(43), eabc1370 (1-14) (2020). doi:10.1126/sciadv.abc1370
The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α$_1$-Antitrypsin d
The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α$_1$-Antitrypsin d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8c61ef7f150fa332ee521311595060
Autor:
Ryo Yamamoto, Rosa Miquel, Rocio Sancho, Andrew Bonham, Wayel Jassem, Stephen R. Quake, Spyros Darmanis, Deniz Kent, Bénédicte Oulès, Maria Paola Serra, Joe M. Segal, Sarah A. Teichmann, Hiromitsu Nakauchi, Guy Emerton, S. Tamir Rashid, Alessandra Vigilante, Aileen King, Samuel J.I. Blackford, Soon Seng Ng, Gozde Kar, Nigel Heaton, Daniel J. Wesche, Tu Vinh Luong
Publikováno v:
Segal, J M, Kent, D H, Wesche, D, Ng, S S, Quake, S, Serra, M, Nakauchi, H, Rashid, S T, King, A, Oules, B, Kar, G, Emerton, G, Blackford, S, Darmanis, S, Miquel, R, Luong, T V, Yamamoto, R, Bonham, A, Jassem, W, Heaton, N, Vigilante, A, Sancho, R & Teichmann, S A 2019, ' Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors ', Nature Communications, vol. 10, no. 1, 3350 . https://doi.org/10.1038/s41467-019-11266-x
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca01778b6f9524ce9dc061cb4df0234
https://kclpure.kcl.ac.uk/ws/files/112627999/NCOMMS_Final.pdf
https://kclpure.kcl.ac.uk/ws/files/112627999/NCOMMS_Final.pdf