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Pharmacokinetics of Intramuscularly Administered Biperiden in Guinea Pigs Challenged with Soman

Autor: Benedict R. Capacio, John H. McDonough, C. E. Byers, S. T. Caro

Publikováno v: Drug and Chemical Toxicology. 26:1-13

Biperiden is an anticholinergic compound that has demonstrated effectiveness for treating organophosphate-induced seizure/convulsions. The plasma levels of biperiden associated with this efficacy have not yet been defined. In this study, the pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9650e29d509e524c1bcdda427680a721
https://doi.org/10.1081/dct-120017553

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The determination of biperiden in plasma using gas chromatography mass spectrometry: pharmacokinetics after intramuscular administration to guinea pigs

Autor: Benedict R. Capacio, C. E. Byers, S. T. Caro, J. R. Smith

Publikováno v: Biomedical chromatography : BMC. 16(1)

A gas chromatographic-mass spectrometric (GC-MS) method has been developed for the analysis of the biperiden from plasma. The method utilizes 290 microl of plasma and a simple hexane extraction/clean-up procedure. Standard curves were linear over the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25ac19cffbafa9856e951f552df82b2
https://pubmed.ncbi.nlm.nih.gov/11816011

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