A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways inPlasmodium vivaxHypnozoites

Autor: S. P. Maher, M. A. Bakowski, A. Vantaux, E. L. Flannery, C. Andolina, M. Gupta, Y. Antonova-Koch, M. Argomaniz, M. Cabrera-Mora, B. Campo, A. T. Chao, A. K. Chatterjee, W. T. Cheng, C. A. Cooper, K. Cottier, M. R. Galinski, A. Harupa-Chung, H. Ji, S. B. Joseph, T. Lenz, S. Lonardi, J. Matheson, S. A. Mikolajczak, V. Padín-Irizarry, K. Pan, J. Péneau, J. Prudhomme, C. Roesch, S. S. Sabnis, C. L. Saney, J. Sattabongkot, S. Sereshki, S. Suriyakan, T. Moeller, R. Ubalee, Y. Wang, P. Wasisakun, J. Yin, C. W. McNamara, C. J. Joyner, F. Nosten, B. Witkowski, K. G. Le Roch, D. E. Kyle

Publikováno v: bioRxiv

Radical cure ofPlasmodium vivaxmalaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug targets, we

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https://doi.org/10.1101/2023.01.31.526483

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A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites.

Autor: Maher SP; Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA., Bakowski MA; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Vantaux A; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., Flannery EL; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA., Andolina C; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand., Gupta M; Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA., Antonova-Koch Y; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Argomaniz M; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA., Cabrera-Mora M; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA., Campo B; Medicines for Malaria Venture (MMV); Geneva, 1215, Switzerland., Chao AT; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA., Chatterjee AK; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Cheng WT; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA., Chuenchob E; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA., Cooper CA; Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA., Cottier K; BioIVT Inc.; Westbury, NY, 11590, USA., Galinski MR; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA.; Division of Infectious Diseases, Department of Medicine, Emory University; Atlanta, GA, 30329, USA., Harupa-Chung A; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA., Ji H; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA., Joseph SB; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Lenz T; Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA., Lonardi S; Department of Computer Science and Engineering, University of California; Riverside, CA, 92521, USA., Matheson J; Department of Microbiology and Immunology, University of Otago; Dunedin, 9016, New Zealand., Mikolajczak SA; Novartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research; Emeryville, CA, 94608, USA., Moeller T; BioIVT Inc.; Westbury, NY, 11590, USA., Orban A; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., Padín-Irizarry V; Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.; School of Sciences, Clayton State University; Morrow, GA, 30260, USA., Pan K; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Péneau J; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., Prudhomme J; Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA., Roesch C; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., Ruberto AA; Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA., Sabnis SS; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA., Saney CL; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA., Sattabongkot J; Mahidol Vivax Research Unit, Mahidol University; Bangkok, 10400, Thailand., Sereshki S; Department of Computer Science and Engineering, University of California; Riverside, CA, 92521, USA., Suriyakan S; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand., Ubalee R; Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS); Bangkok, 10400, Thailand., Wang Y; Department of Chemistry, University of California; Riverside, CA, 92521.; Environmental Toxicology Graduate Program, University of California; Riverside, CA, 92521, USA., Wasisakun P; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand., Yin J; Environmental Toxicology Graduate Program, University of California; Riverside, CA, 92521, USA., Popovici J; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., McNamara CW; Calibr, a division of The Scripps Research Institute; La Jolla, CA, 92037, USA., Joyner CJ; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA, 30602, USA.; International Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University; Atlanta, GA, 30329, USA., Nosten F; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit; Mae Sot, Tak, 63110, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford; Oxford, OX3 7LG, UK., Witkowski B; Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia; Phnom Penh, 120 210, Cambodia., Le Roch KG; Department of Molecular, Cell, and Systems Biology, University of California; Riverside, CA, 92521, USA., Kyle DE; Center for Tropical & Emerging Global Disease, University of Georgia; Athens, GA, 30602, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 25. Date of Electronic Publication: 2024 Mar 25.