Zobrazeno 1 - 10
of 220
pro vyhledávání: '"S. Stoney Simons"'
Autor:
Zuqin Nie, Chunhua Guo, Subhendu K Das, Carson C Chow, Eric Batchelor, S Stoney Simons Jnr, David Levens
Publikováno v:
eLife, Vol 9 (2020)
Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier increasing output at all active promoters. Both models rest on large-scale g
Externí odkaz:
https://doaj.org/article/0acc578d75da4e5c892d7a40c0cd7806
Autor:
Carson C. Chow, S. Stoney Simons
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Glucocorticoid steroids are among the most prescribed drugs each year. Nonetheless, the many undesirable side effects, and lack of selectivity, restrict their greater usage. Research to increase glucocorticoid specificity has spanned many years. Thes
Externí odkaz:
https://doaj.org/article/5f546db78022499f9e8abcf9cef520f1
Publikováno v:
AIMS Molecular Science, Vol 2, Iss 2, Pp 101-123 (2015)
The different amounts of residual partial agonist activity (PAA) of antisteroids under assorted conditions have long been useful in clinical applications but remain largely unexplained. Not only does a given antagonist often afford unequal induction
Externí odkaz:
https://doaj.org/article/78ad84c6099844899201884edba811e7
Autor:
Carson C Chow, Kelsey K Finn, Geoffery B Storchan, Xinping Lu, Xiaoyan Sheng, S Stoney Simons
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 3, p e1004122 (2015)
Gene repression by transcription factors, and glucocorticoid receptors (GR) in particular, is a critical, but poorly understood, physiological response. Among the many unresolved questions is the difference between GR regulated induction and repressi
Externí odkaz:
https://doaj.org/article/5f0d09ccba104b98afc09486a1f132dd
Autor:
Jacob Haqq-Misra, S. Stoney Simons
Publikováno v:
Futures. 106:24-32
The failure to resolve the 70 year old Fermi paradox has been limited by the vastness of the Universe, the inability to search even a fraction of the Universe in a reasonable time period, and the lack of agreement on the criteria for life. We suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64fb2b8f315335caf2741b5050fa88e5
https://doi.org/10.1016/j.futures.2018.06.019
https://doi.org/10.1016/j.futures.2018.06.019
Publikováno v:
In Molecular and Cellular Endocrinology 2008 295(1):59-69
Autor:
Chunhua Guo, David Levens, Carson C. Chow, Zuqin Nie, S Stoney Simons Jnr, Eric Batchelor, Subhendu K. Das
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier increasing output at all active promoters. Both models rest on large-scale g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830e2325382b7077a18c3f12d95be3b7
http://europepmc.org/articles/PMC7384857
http://europepmc.org/articles/PMC7384857
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30225 (2012)
Cofactors are intimately involved in steroid-regulated gene expression. Two critical questions are (1) the steps at which cofactors exert their biological activities and (2) the nature of that activity. Here we show that a new mathematical theory of
Externí odkaz:
https://doaj.org/article/85cc43e416d946efaca8d8e6e102b7ab
Autor:
S. Stoney Simons, Carson C. Chow
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Frontiers in Endocrinology
Frontiers in Endocrinology
Glucocorticoid steroids are among the most prescribed drugs each year. Nonetheless, the many undesirable side effects, and lack of selectivity, restrict their greater usage. Research to increase glucocorticoid specificity has spanned many years. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b692b75bf9815be328c045eac7490
http://journal.frontiersin.org/article/10.3389/fendo.2018.00076/full
http://journal.frontiersin.org/article/10.3389/fendo.2018.00076/full