Zobrazeno 1 - 10
of 262
pro vyhledávání: '"S. Srikumaran"'
Autor:
S. Srikumaran, Holly A Klink, Clayton L. Kelling, Christina L. Topliff, Ryan P Brady, Kent M. Eskridge
Publikováno v:
Vaccine. 24:3388-3395
Bovine respiratory syncytial virus (BRSV) is an etiological component of the bovine respiratory tract disease complex. Infection with BRSV following vaccination, or re-infection following natural infection is common since protection is incomplete. Th
Autor:
S. Srikumaran, S Sivaloganathan
Publikováno v:
Computer-Aided Design and Applications. 2:507-516
It is a fundamental requirement that during the design of a component, its manufacturability to the required quality at an acceptable cost must be ensured. In machining, achieving the required quality is ensured by performing all machining quality cr
Publikováno v:
Journal of General Virology. 85:349-353
Equine herpesvirus-1 (EHV-1) downregulates surface expression of major histocompatibility complex (MHC) class I molecules on infected cells. The objective of this study was to investigate whether EHV-1 interferes with peptide translocation by the tra
Autor:
S. Srikumaran, Nagendra R. Hegde, James Rayner, William J. Martin, Anne S. De Groot, Vishvanath Nene
Publikováno v:
International Journal for Parasitology. 33:641-653
T cell responses play an important role in immunity to parasites and other microbial agents of infectious diseases, therefore a number of T cell-directed vaccines are in development. Computer-driven algorithms that facilitate the discovery of T cell
Publikováno v:
Viral Immunology. 15:595-608
Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Fur
Autor:
Muralidhar S. Deshpande, Nagendra R. Hegde, Mangala J Hariharan, Thanuja C Ambagala, S. Srikumaran, Manjula Navaratnam
Publikováno v:
Vaccine. 20:3744-3751
Cytotoxic T-lymphocytes (CTLs) are critical for the defense against herpesvirus infections, in which cell-to-cell spread occurs earlier than the hematogenous spread. The ability of bovine herpesvirus-1 (BHV-1) to undergo latency, to induce apoptosis
Autor:
Aruna P. N. Ambagala, Marcus E. Kehrli, Thanuja C Ambagala, Muralidhar S. Deshpande, S. Srikumaran
Publikováno v:
Infection and Immunity. 70:5058-5064
Leukotoxin (Lkt) secreted by Mannheimia ( Pasteurella ) haemolytica is an RTX toxin which is specific for ruminant leukocytes. Lkt binds to β 2 integrins on the surface of bovine leukocytes. β 2 integrins have a common β subunit, CD18, that associ
Publikováno v:
Immunogenetics. 54:30-38
The transporter associated with antigen processing (TAP) 1/2 heterodimer is essential for the transport of antigenic peptides from the cytosol into the lumen of the endoplasmic reticulum. Bovine herpesvirus 1 (BHV-1) inhibits bovine TAP (BoTAP) activ
Autor:
Muralidhar S. Deshpande, Manjula Navaratnam, Douglas S. Zatechka, Mangala J Hariharan, S. Srikumaran
Publikováno v:
Vaccine. 19:1425-1434
Epitope-based vaccines offer a promising alternative to modified live vaccines against viruses such as herpesviruses which give rise to latent infections, and induce immunosuppression. The success of this approach depends on the ability to direct the
Publikováno v:
Archives of Virology. 145:2027-2046
Bovine herpesvirus 1 (BHV-1) is a major pathogen of cattle, causing significant disease including immunosuppression in infected animals. In vitro, the surface expression of major histocompatibility complex (MHC) class I molecules, crucial for an appr