Zobrazeno 1 - 10
of 11
pro vyhledávání: '"S. Spence McCachren"'
Autor:
S. Spence McCachren, James Moon, J. Thaddeus Beck, Nerses S. Tchekmedyian, Robert P. Whitehead, Vernon K. Sondak, Evan M. Hersh, Wolfram E. Samlowski
Publikováno v:
Cancer. 100:1699-1704
BACKGROUND Single-agent chemotherapy with dacarbazine continues to be the standard of care for the treatment of metastatic melanoma. However, there is a large population of patients who have failed first-line therapy and might benefit from additional
Publikováno v:
Journal of clinical immunology. 15(6)
The cell surface hyaluronate receptor CD44 has previously been shown to have immunomodulatory activity and to be upregulated in inflammatory synovitis. Since these findings were reported, the genomic structure of CD44 has been delineated, and multipl
Publikováno v:
Experimental cell research. 210(2)
The extracellular matrix glycoprotein tenascin is limited to the periductal matrix of normal breast tissue but is markedly increased in both malignant and fibroadenomatous proliferations. It has been hypothesized that the changes in tenascin expressi
Publikováno v:
Arthritis and rheumatism. 35(10)
Objective. Tenascin is an extracellular matrix glycoprotein with effects on cell adhesion, cell migration, and lymphocyte activation. We proposed to identify the expression of human tenascin messenger RNA (mRNA) and protein in inflammatory synovitis
Autor:
S. Spence McCachren
Publikováno v:
Arthritis and rheumatism. 34(9)
The expression of messenger RNA encoding neutral metalloproteinases and the tissue inhibitor of metalloproteinases (TIMP) in human arthritic synovium was evaluated in situ, using RNA probes. Interstitial collagenase and stromelysin were expressed by
Publikováno v:
Journal of clinical immunology. 10(1)
Collagenase has been implicated as playing an important role in the connective tissue destruction that is a major feature of rheumatoid arthritis. Numerous cell types in the hyperplastic rheumatoid synovium are capable of synthesizing collagenase. Pa
Autor:
Robert P. Whitehead, James Moon, S. Spence McCachren, Evan M. Hersh, Wolfram E. Samlowski, J. Thaddeus Beck, Nerses S. Tchekmedyian, Vernon K. Sondak
Publikováno v:
Cancer (0008543X); Apr2004, Vol. 100 Issue 8, p1699-1704, 6p
Publikováno v:
Clinics in Geriatric Medicine. 3:575-586
Until now there has not been a treatise summarizing the management of oncologic emergencies in the aged. All of the well-described acute complications of malignancy occur in the elderly. Such clinical events are best labeled urgent rather than emerge
Publikováno v:
Biochemical and Biophysical Research Communications. 151:574-582
Human promyelocytic leukemia cells (HL-60) differentiate along a monocytoid pathway in response to recombinant human tumor necrosis factor or recombinant human interferon gamma. Together, these agents act synergistically to induce phenotypic differen
Publikováno v:
Blood. 68:412-416
The human promyelocytic leukemia cell line HL-60 is induced to differentiate along a myelocytic pathway by dibutyryl cyclic adenosine monophosphate (dbcAMP). Other cAMP analogs are ineffective as inducing agents. The effect of these compounds on expr