Zobrazeno 1 - 10
of 744
pro vyhledávání: '"S. Silverberg"'
Autor:
Shaji Sebastian, Laurent Peyrin-Biroulet, Silvio Danese, Séverine Vermeire, Simon Travis, Jean-Frederic Colombel, Brian G Feagan, Vipul Jairath, Guangyong Zou, Geert R D’Haens, William J Sandborn, Gordon W Moran, Christopher Ma, Peter Bossuyt, Daniel Green, Mark S Silverberg, Maria Kłopocka, Marek Horynski, Stefanie C McFarlane, Zhongya Wang, Shashi Adsul, Marcelo Freire, Gabriela Radulescu, Julie Sigler, Jurij Hanžel, Rocio Sedano, Naveen Arya, Melanie Beaton, William Harlan, Rima Petroniene, Lukasz Wolanski
Publikováno v:
BMJ Open Gastroenterology, Vol 11, Iss 1 (2024)
Introduction Symptoms, endoscopy and histology have been proposed as therapeutic targets in ulcerative colitis (UC). Observational studies suggest that the achievement of histologic remission may be associated with a lower risk of complications, comp
Externí odkaz:
https://doaj.org/article/90b48a3e247b434da3279f2d6dcef059
Autor:
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Girish Nadkarni, Lee A. Denson, Harry Ostrer, Adam P. Levine, Elena R. Schiff, Anthony W. Segal, Subra Kugathasan, Peter D. Stenson, David N. Cooper, L. Philip Schumm, Scott Snapper, Mark J. Daly, Talin Haritunians, Richard H. Duerr, Mark S. Silverberg, John D. Rioux, Steven R. Brant, Dermot P. B. McGovern, Judy H. Cho, Yuval Itan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inflammatory bowel disease (IBD) is a group of chronic digestive tract inflammatory conditions whose genetic etiology is still poorly understood. The incidence of IBD is particularly high among Ashkenazi Jews. Here, we identify 8 novel and p
Externí odkaz:
https://doaj.org/article/9b4ce2bc11f1400dba2682d34318447c
Autor:
Brindusa Truta, Ferdouse Begum, Lisa Wu Datta, Steven R. Brant, Judy H. Cho, Richard H. Duerr, Dermot B.P. McGovern, John R. Rioux, Mark S. Silverberg
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 1, Pp 22-32 (2023)
Background and Aims: Inflammatory bowel disease (IBD) is caused by interaction of genetic and environmental risk factors. We evaluated potential determinants of the post-1990 increased incidence in North America. Methods: Using fitted generalized lin
Externí odkaz:
https://doaj.org/article/dd85c3f4ae8a48deb59f327504bffcdd
Autor:
Tiago S. Medina, Alex Murison, Michelle Smith, Gabriela S. Kinker, Ankur Chakravarthy, Glauco A. F. Vitiello, Williams Turpin, Shu Yi Shen, Helen L. Yau, Olga F. Sarmento, William Faubion, Mathieu Lupien, Mark S. Silverberg, Cheryl H. Arrowsmith, Daniel D. De Carvalho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that
Externí odkaz:
https://doaj.org/article/48032f330d2f4012b81f6e5ecfa9adc0
Autor:
Bryan Linggi, Vipul Jairath, Guangyong Zou, Lisa M. Shackelton, Dermot P. B. McGovern, Azucena Salas, Bram Verstockt, Mark S. Silverberg, Shadi Nayeri, Brian G. Feagan, Niels Vande Casteele
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Publicly available ulcerative colitis (UC) gene expression datasets from observational studies and clinical trials include inherently heterogeneous disease characteristics and methodology. We used meta-analysis to identify a robust UC gene s
Externí odkaz:
https://doaj.org/article/7837a75292a542ebb02f0ecb74810914
Autor:
Roya M. Dayam, Jaclyn C. Law, Rogier L. Goetgebuer, Gary Y.C. Chao, Kento T. Abe, Mitchell Sutton, Naomi Finkelstein, Joanne M. Stempak, Daniel Pereira, David Croitoru, Lily Acheampong, Saima Rizwan, Klaudia Rymaszewski, Raquel Milgrom, Darshini Ganatra, Nathalia V. Batista, Melanie Girard, Irene Lau, Ryan Law, Michelle W. Cheung, Bhavisha Rathod, Julia Kitaygorodsky, Reuben Samson, Queenie Hu, W. Rod Hardy, Nigil Haroon, Robert D. Inman, Vincent Piguet, Vinod Chandran, Mark S. Silverberg, Anne-Claude Gingras, Tania H. Watts
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
BACKGROUND Limited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMID).METHODS This observational cohort study examined the immunogenicity of SARS-CoV-2 mR
Externí odkaz:
https://doaj.org/article/5efd773f1af64049a8135d42e2a56cd2
Autor:
Williams Turpin, Larbi Bedrani, Osvaldo Espin-Garcia, Wei Xu, Mark S. Silverberg, Michelle I. Smith, Juan Antonio Raygoza Garay, Sun-Ho Lee, David S. Guttman, Anne Griffiths, Paul Moayyedi, Remo Panaccione, Hien Huynh, Hillary A. Steinhart, Guy Aumais, Levinus A. Dieleman, Dan Turner, CCC IBD GEM Project research team, Andrew D. Paterson, Kenneth Croitoru
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Genetic analyses have identified many variants associated with the risk of inflammatory bowel disease (IBD) development. Among these variants, the ones located within the NOD2 gene have the highest odds ratio of all IBD genetic ri
Externí odkaz:
https://doaj.org/article/a6f5c81838664f51b13ca00a2a775fc8
Autor:
S Vieujean, J O Lindsay, D Rubin, F D’Amico, V Ahuja, M S Silverberg, A Sood, J K Yamamoto-Furusho, M Nagahori, M Watanabe, I E Koutroubakis, K Foteinogiannopoulou, A Walsh, A Outtier, M T Abreu, M Dubinsky, C Siegel, E Louis, I Dotan, W Reinisch, S Danese, L Peyrin-Biroulet
Publikováno v:
Journal of Crohn's and Colitis. 17:i794-i797
Background Recruitment rates for phase 2b/3 randomized controlled trials (RCTs) in IBD have substantially dropped over time. Several steps are required prior to successful patient randomization. Initially the physician must propose a trial to a poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c64c0b4a6137305b48722054b0293fb2
https://doi.org/10.1093/ecco-jcc/jjac190.0794
https://doi.org/10.1093/ecco-jcc/jjac190.0794
Autor:
D Bettenworth, M E Baker, W Bemelmann, D Bruining, G D’Haens, A D’Hoore, A Dignass, I Dotan, B G Feagan, R Feakins, P Fleshner, J G Fletcher, I Gordon, C Ha, H Gaylyn, V Jairath, C Lu, R Lyu, S C Ng, J Panes, G Rogler, R Mao, J Rimola, W J Sandborn, B Siegmund, M S Silverberg, S Taylor, B Verstockt, F Rieder
Publikováno v:
Journal of Crohn's and Colitis. 17:i418-i420
Background Small bowel fibrostenotic strictures are common in patients with Crohn’s disease (CD). No global consensus recommendations on definitions, diagnosis and clinical management are available. Methods Several systematic reviews followed by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fccc6ad6d832170368b6761072c90c0f
https://doi.org/10.1093/ecco-jcc/jjac190.0400
https://doi.org/10.1093/ecco-jcc/jjac190.0400
Autor:
M. Ellen Kuenzig, Jeff Yim, Stephanie Coward, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Herman W. Barkema, Mark S. Silverberg, Peter L. Lakatos, Paul L. Beck, Richard Fedorak, Levinus A. Dieleman, Karen Madsen, Remo Panaccione, Subrata Ghosh, Gilaad G. Kaplan
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 188-196 (2017)
Background: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). Methods: Phase 1: MEDLINE
Externí odkaz:
https://doaj.org/article/356c21b845b8434e9f3ffc98edc2a706