Zobrazeno 1 - 10
of 396
pro vyhledávání: '"S. Shoichet"'
Autor:
Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace, Molly S. Shoichet
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo. However, previo
Externí odkaz:
https://doaj.org/article/adf82bd9d98a46a19caf66f82f4d65a4
Autor:
Mickael Dang, Molly S. Shoichet
Publikováno v:
Advanced Science, Vol 11, Iss 8, Pp n/a-n/a (2024)
Abstract The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability. Biomaterial‐based app
Externí odkaz:
https://doaj.org/article/60d8b0fbcf3248e7ba3be0d0ab2b57a3
Autor:
Eric D. Jong, Sabiha Hacibekiroglu, Lily Guo, Evan Sawula, Biao Li, Chengjin Li, Margaret T. Ho, Molly S. Shoichet, Valerie A. Wallace, Andras Nagy
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Retinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or blindness. Due to its genetic heterogeneity, developing a new gene therapy to correct every gen
Externí odkaz:
https://doaj.org/article/9cfb8522be4844fea76312b601b9e813
Autor:
Laura J. Smith, Arianna Skirzynska, Allysia A. Chin, Amy E. Arnold, Michelle Kushida, Peter B. Dirks, Molly S. Shoichet
Publikováno v:
ACS Materials Au, Vol 3, Iss 5, Pp 514-527 (2023)
Externí odkaz:
https://doaj.org/article/7d24600fbd74434a91b7c0e68b20103a
Autor:
Adam Pietrobon, Julien Yockell‐Lelièvre, Nicole Melong, Laura J. Smith, Sean P. Delaney, Nadine Azzam, Chang Xue, Nishanth Merwin, Eric Lian, Alberto Camacho‐Magallanes, Carole Doré, Gabriel Musso, Lisa M. Julian, Arnold S. Kristof, Roger Y. Tam, Jason N. Berman, Molly S. Shoichet, William L. Stanford
Publikováno v:
Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Abstract Lymphangioleiomyomatosis (LAM) is a rare disease involving cystic lung destruction by invasive LAM cells. These cells harbor loss‐of‐function mutations in TSC2, conferring hyperactive mTORC1 signaling. Here, tissue engineering tools are
Externí odkaz:
https://doaj.org/article/a106fabeaeb643adbc219e24ad198f59
Autor:
Eric N. Donders, Kai V. Slaughter, Christian Dank, Ahil N. Ganesh, Brian K. Shoichet, Mark Lautens, Molly S. Shoichet
Publikováno v:
Advanced Science, Vol 10, Iss 13, Pp n/a-n/a (2023)
Abstract Colloidal drug aggregates enable the design of drug‐rich nanoparticles; however, the efficacy of stabilized colloidal drug aggregates is limited by entrapment in the endo‐lysosomal pathway. Although ionizable drugs are used to elicit lys
Externí odkaz:
https://doaj.org/article/6381e627e47b4947a800447fbe4cab1f
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
Autor:
Victor Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Eve Janelle, Nathalie Vernoux, Marie-Ève Tremblay, Tobias Fuehrmann, Molly S. Shoichet, Steve Lacroix
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of
Externí odkaz:
https://doaj.org/article/2fc70e1ee997470e9a54f3634a92fb6e
Autor:
Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan-Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1433-1448 (2018)
Summary: Treatment of chronic spinal cord injury (SCI) is challenging due to cell loss, cyst formation, and the glial scar. Previously, we reported on the therapeutic potential of a neural progenitor cell (NPC) and chondroitinase ABC (ChABC) combinat
Externí odkaz:
https://doaj.org/article/7a1ee5dff6e0435aad60f21cfb9900c3
Autor:
Saeed Khalili, Brian G. Ballios, Justin Belair-Hickey, Laura Donaldson, Jeff Liu, Brenda L.K. Coles, Kenneth N. Grisé, Tahani Baakdhah, Gary D. Bader, Valerie A. Wallace, Gilbert Bernier, Molly S. Shoichet, Derek van der Kooy
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 215-227 (2018)
During development, multipotent progenitors undergo temporally-restricted differentiation into post-mitotic retinal cells; however, the mechanisms of progenitor division that occurs during retinogenesis remain controversial. Using clonal analyses (li
Externí odkaz:
https://doaj.org/article/98e67184a2f94cb69836b8a1c495c678
Autor:
Carter J. Teal, Margaret T. Ho, Lia Huo, Hidekiyo Harada, Laura C. Bahlmann, Thierry Léveillard, Philippe P. Monnier, Arun Ramachandran, Molly S. Shoichet
Publikováno v:
Acta Biomaterialia. 161:37-49