Zobrazeno 1 - 10
of 708
pro vyhledávání: '"S. Shefer"'
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 12, Pp 2471-2476 (1998)
The mechanism for the catalytic reduction of the double bond at C-7,8 in 7-dehydrocholesterol by 3β-hydroxysterol Δ7-reductase was investigated by testing structurally related sterols as substrates and potential inhibitors. The hepatic smooth endop
Externí odkaz:
https://doaj.org/article/378fbd644dd646b39cfc0c25cd2ef0ea
Publikováno v:
Journal of Lipid Research, Vol 16, Iss 4, Pp 280-286 (1975)
This paper describes studies dealing with the nature of the C27 pentahydroxy bile alcohols present in the bile and feces of two patients with cerebrotendinous xanthomatosis (CTX). The presence of a bile alcohol having the structure 5β-cholestane-3α
Externí odkaz:
https://doaj.org/article/07cb60b151054b9b9a5f4601678ead97
Publikováno v:
Journal of Lipid Research, Vol 16, Iss 2, Pp 92-96 (1975)
A rapid method was developed to measure cholesterol 7 α-hydroxylase activity of hepatic microsomes by the direct determination of the mass of 7 α-hydroxycholesterol formed. The method is based on the quantitative acetylation of the incubation mixtu
Externí odkaz:
https://doaj.org/article/efba702b83e34f44bfd175439d1567e1
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 2, Pp 146-151 (1974)
Methods were developed to determine the activity of the microsomal enzyme cholesterol 7α-hydroxylase in human liver. The enzyme assay could be performed with as little as 20 mg of fresh liver tissue, thus making the procedure applicable to specimens
Externí odkaz:
https://doaj.org/article/12c57603d5bb4ddf85b49d987f8d7096
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 1, Pp 94-98 (1974)
Procedures were developed for the determination of the activity of the microsomal enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG CoA reductase, EC 1.1.1.34) in human liver. The enzyme assay could be carried out with as little as 20 mg of fresh
Externí odkaz:
https://doaj.org/article/88cf399715c541bfba02d38d19628970
Publikováno v:
Journal of Lipid Research, Vol 14, Iss 4, Pp 400-405 (1973)
The specific activity (concentration) of microsomal HMG CoA reductase of intestinal crypt cells was studied in rats fed sterols and bile acids, either singly or in combination. It was found that the basal activity of the reductase was not suppressed
Externí odkaz:
https://doaj.org/article/88a23f7e773d4544aca880d6c230da5f
Publikováno v:
Journal of Lipid Research, Vol 14, Iss 5, Pp 573-580 (1973)
Specific activities of the hepatic microsomal enzymes 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase and cholesterol 7α-hydroxylase were studied in rats fed sterols and bile acids. The administration of bile acids (taurocholate, taurodeoxycholat
Externí odkaz:
https://doaj.org/article/f8cb9ae4a2c647a6820552d9677576a8
Publikováno v:
Journal of Lipid Research, Vol 13, Iss 3, Pp 402-412 (1972)
Methods were developed for the determination of HMG CoA (3-hydroxy-3-methylglutaryl CoA) reductase activity in subcellular fractions of intestinal mucosa and liver of Wistar strain rats. In the liver, reductase activity was located exclusively in the
Externí odkaz:
https://doaj.org/article/3d822a07f9044b7caf0c74f412f531b1
Publikováno v:
Journal of Lipid Research, Vol 9, Iss 2, Pp 237-243 (1968)
The role of 7α,l2α-dihydroxycholest-4-en-3-one as an intermediate in the formation of 5α-bile acids from cholesterol was investigated with liver preparations of Iguana iguana in vitro. The microsomal fraction of iguana liver catalyzed the transfor
Externí odkaz:
https://doaj.org/article/499d571227fc4f97800b2f387a4e0409
Publikováno v:
Journal of Lipid Research, Vol 13, Iss 5, Pp 571-573 (1972)
HMG CoA reductase activity of rat intestinal mucosa has a diurnal rhythm which coincides with the diurnal variation of the hepatic HMG CoA reductase but has a lower amplitude. The rhythmic variation of the intestinal reductase was present in both jej
Externí odkaz:
https://doaj.org/article/d4d7313c875e4849971cb0e9ddeee50b