Zobrazeno 1 - 10
of 58
pro vyhledávání: '"S. Saller"'
Autor:
Liza Coyer, Aylin Sogan-Ekinci, Benedikt Greutélaers, Julia Kuhn, Franziska S. Saller, Jana Hailer, Stefanie Böhm, Rainer Brosch, Christiane Wagner-Wiening, Merle M. Böhmer
Publikováno v:
Microorganisms, Vol 11, Iss 4, p 961 (2023)
In 2020, a record number of tick-borne encephalitis (TBE) cases was reported in major endemic areas in Germany, i.e., the southern federal states of Baden-Wuerttemberg and Bavaria. Most cases were unvaccinated. Other tick-borne diseases (TBDs), inclu
Externí odkaz:
https://doaj.org/article/b445a9ffaf9549479470236fb7a63301
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3846-3859 (2017)
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzym
Externí odkaz:
https://doaj.org/article/caf0ef9e648d468094e235c5382d0983
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4bf91e4a3197215eb77ef358cd0bbb
https://doi.org/10.1126/scisignal.abh1083
https://doi.org/10.1126/scisignal.abh1083
Autor:
I. Schäfer, Natalie Hoppe, Philipp Albrecht, S. König, J Merz, K Bulatova, J. Engelmann, Dennis Wolf, Peter Stachon, L. Hertle, Andreas Zirlik, A. Nettesheim, C. Bode, S Von Garlen, O. Groß, Alexander Peikert, B. S. Saller, L Karnbrock, Ingo Hilgendorf, D Dimanski, C. von zur Muhlen
Publikováno v:
Purinergic Signalling
Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743874ea63daa3151b395148ec92dce4
https://doi.org/10.1007/s11302-021-09798-3
https://doi.org/10.1007/s11302-021-09798-3
Publikováno v:
Current Opinion in Biotechnology. 68:300-309
The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8917e8dec2fd4f1dcf2699a117621d6a
https://doi.org/10.1016/j.copbio.2021.03.009
https://doi.org/10.1016/j.copbio.2021.03.009
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Tobacco Control. 31:416-423
BackgroundRecent years have seen a rapid increase in the popularity of electronic cigarettes (e-cigarettes) among adolescents in the USA. Evidence on their role in the continuation of or abstinence from cigarette smoking among young smokers remains s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da96926171d0f1bd95290c2291ca276b
https://doi.org/10.1136/tobaccocontrol-2020-055943
https://doi.org/10.1136/tobaccocontrol-2020-055943
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Anna Kostina, Svenja Wöhrle, Stephan Flemming, Larissa Fischer, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian Parker, Andreas Boettcher, Christopher J. Farady, Rolf Backofen, Marta Rodriguez-Franco, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Inflammasomes are intracellular protein complexes that control proteolytic maturation and secretion of inflammatory interleukin-1 (IL-1) family cytokines and are thus important in host defense. While some inflammasomes are activated simply by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91918a639a74468417a76d5d58c4b680
https://doi.org/10.1101/2022.02.19.480941
https://doi.org/10.1101/2022.02.19.480941
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbc2cfe838fe220f01013547adecb90
https://doi.org/10.1038/s41467-020-15497-1
https://doi.org/10.1038/s41467-020-15497-1