Zobrazeno 1 - 10
of 14
pro vyhledávání: '"S. Saalau-Bethell"'
Autor:
Christopher William Murray, Joseph E. Coyle, Sharna J. Rich, Anne Cleasby, Tracey Ann Sambrook, S. Saalau-Bethell, Jeff Yon, Valerio Berdini, Mladen Vinkovic, Victoria Lock, M. Alistair O’Brien, Miles Congreve, Harren Jhoti
Publikováno v:
'ChemMedChem ', vol: 9, pages: 823-832 (2014)
Chemmedchem
Chemmedchem
Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. Here, we report the first crystal structure of the human enzyme that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c763854d609cb5fa0221a0ecc011d10d
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:39648
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:39648
Autor:
Pamela A. Williams, Harren Jhoti, Andrew James Woodhead, Maria Grazia Carr, Puja Pathuri, Christopher William Murray, Caroline Richardson, Brent Graham, S. Saalau-Bethell, Gianni Chessari, Steven Douglas Hiscock, Joseph T. Coyle, Sharna J. Rich
Publikováno v:
Nature chemical biology
Here we report the discovery of a highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein. Using a chemical lead, identified by fragment screening and structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f2e6847ee9081cee0b58d0650637d7
https://doi.org/10.1038/nchembio.1081
https://doi.org/10.1038/nchembio.1081
Autor:
Brent Graham, David R. McGivern, S. Saalau-Bethell, Christopher Charles Frederick Hamlett, Takahiro Masaki, William Lovell
Hepatitis C virus (HCV) NS3 is a multifunctional protein composed of a protease domain and a helicase domain linked by a flexible linker. Protease activity is required to generate viral nonstructural (NS) proteins involved in RNA replication. Helicas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4091d68eb04c3fceb4bec852cc4d9aab
https://europepmc.org/articles/PMC4442512/
https://europepmc.org/articles/PMC4442512/
Autor:
O'Brien, P.A. Williams, G. Chessari, M.G. Carr, S. Hiscock, P. Pathuri, Joseph E. Coyle, M. Vinkovic, T. Sambrook, C. Richardson, Anne Cleasby, J.R. Yon, M. Congreve, S. Saalau-Bethell, H. Jhoti, V. Lock, A.J. Woodhead, Christopher William Murray, B. Graham, V Berdini, Sharna J. Rich
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 71:s38-s38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12042e1cee002767ecb265983acc5045
https://doi.org/10.1107/s2053273315099398
https://doi.org/10.1107/s2053273315099398
Autor:
Ian Collins, T. McHardy, Harren Jhoti, Christopher Charles Frederick Hamlett, David Barford, Steven John Woodhead, Michelle D. Garrett, Marcel L. Verdonk, T.G. Davies, Brent Graham, Paul Workman, S. Saalau-Bethell
Publikováno v:
Journal of molecular biology. 367(3)
Although the crystal structure of the anti-cancer target protein kinase B (PKBbeta/Akt-2) has been useful in guiding inhibitor design, the closely related kinase PKA has generally been used as a structural mimic due to its facile crystallization with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abda21414f2cc93545723beefc6397e5
https://pubmed.ncbi.nlm.nih.gov/17275837
https://pubmed.ncbi.nlm.nih.gov/17275837
Autor:
H. Jhoti, J.R. Yon, A.J. Woodhead, M.G. Carr, C. Richardson, Neil T. Thompson, P. Pathuri, R. McMenamin, Joseph E. Coyle, S. Saalau-Bethell, M. Verdonk, Sharna J. Rich, Christopher William Murray, C.C.F. Hamlett, David C. Rees, B. Graham, P.A. Williams, G. Chessari, S. Hiscock, M. Vinkovic, M. Frederickson, M. Reader, F.P. Holding
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 68:s27-s27
NS3/4a enzyme via structure-based drug design Puja Pathuri, Susanne M. Saalau-Bethell, Andrew J. Woodhead, Maria G. Carr, Gianni Chessari, Joseph Coyle, a Martyn Frederickson, Brent Graham, Chris Hamlett, Steven D. Hiscock, Finn P. Holding, Harren Jh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd7909058a44075d77af7fa1e52dd3f
https://doi.org/10.1107/s0108767312099473
https://doi.org/10.1107/s0108767312099473
Autor:
S. Saalau-Bethell, Neil T. Thompson, A.J. Woodhead, H. Willems, Joseph E. Coyle, M. Vinkovic, S. Hiscock, H. Jhotti, M. Verdonk, F.P. Holding, P.A. Williams, G. Chessari, C. Richardson, C. Murray, Sharna J. Rich, Brent Graham
Publikováno v:
Journal of Hepatology. 56:S339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9d73d25278745149741c8469e908b9
https://doi.org/10.1016/s0168-8278(12)60883-6
https://doi.org/10.1016/s0168-8278(12)60883-6
878 PRE-CLINICAL CHARACTERISATION OF A NOVEL DIRECT ACTING ANTIVIRAL AGENT WITH A NEW MODE OF ACTION
Autor:
A. Millemaggi, A.J. Woodhead, H. Willems, M. Carr, M. Reader, C.C.F. Hamlett, S. Saalau-Bethell, Brent Graham, L. Fazal, Nicola E. Wilsher, E. Chiarparin, Vanessa Martins, Jon Lewis, M. Hodder, C. Murray, Sharna J. Rich, M. Sanders, David C. Rees, S. Hiscock, Neil T. Thompson, D. Norton, P. Pathuri
Publikováno v:
Journal of Hepatology. 56:S342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ed26c2ef444a7921735021a481ed13f
https://doi.org/10.1016/s0168-8278(12)60890-3
https://doi.org/10.1016/s0168-8278(12)60890-3
Autor:
David C. Rees, Timothy Perera, E Sement, Martin Page, Yannick Ligny, Christopher William Murray, P Benderitter, Rhalid Akkari, Alexandra Papanikos, Andrew Madin, Laurence Anne Mevellec, Janine Arts, Berthold Wroblowski, Y Simmonet, Steve Mcclue, M. Squires, Neil T. Thompson, Ronaldus Arnodus Hendrika Joseph Gilissen, V Berdini, Gordon Saxty, Sharna J. Rich, Pascal Bonnet, Anne Cleasby, H Newell, S. Saalau-Bethell, V. Tronel, Freyne Eddy Jean Edgard, Werner Constant Johan Embrechts, Peter King, Olivier Querolle, Patrick Angibaud, Marc Willems, Jean Fernand Armand Lacrampe, George Ward
Publikováno v:
Cancer Research. 71:1361-1361
Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. A fragment screening campaign was conducted against the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c5a52d1de2257d30a9811b29f98374
https://doi.org/10.1158/1538-7445.am2011-1361
https://doi.org/10.1158/1538-7445.am2011-1361
Autor:
C Griffiths Jones, Brent Graham, Timothy Perera, Maria Grazia Carr, Rajdeep Kaur Nijjar, Andrew Madin, E Vickerstaff, S. Saalau-Bethell, Anne Cleasby, V Berdini, Darcey Miller, Edward J. Lewis, Joseph E. Coyle, Gordon Saxty, George Ward, Andrew Pike, Michael Alistair O'brien, Christopher William Murray, H Newell, Sharna J. Rich, Patrick Angibaud, M. Squires
Publikováno v:
Cancer Research. 70:5778-5778
Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFr) signalling as being key to the molecular pathology of cancer. This poster will describe fragment based drug discovery u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37204f63c1b0837ad33320e9d12da06e
https://doi.org/10.1158/1538-7445.am10-5778
https://doi.org/10.1158/1538-7445.am10-5778