Zobrazeno 1 - 10
of 33
pro vyhledávání: '"S. S. Bacus"'
Publikováno v:
British Journal of Cancer
ErbB2 and EGFR are attractive oncology therapeutic targets as their overexpression in tumors predicts a poorer clinical outcome in a variety of epithelial malignancies. However, clinical results with therapeutic compounds targeting these receptors ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31ba5e248a21e7f8be599ee345186ea
http://europepmc.org/articles/PMC2747699
http://europepmc.org/articles/PMC2747699
Autor:
Dot Chin, S. S. Bacus, Aysegul A. Sahin, Francisco J. Esteva, Shang Ying Liang, Gabriel N. Hortobagyi, Terry L. Smith, Aman U. Buzdar, Lajos Pusztai
Publikováno v:
Pathology & Oncology Research. 7:171-177
The purpose of this study was to investigate the frequency of expression of the erbB/HER family of growth factor receptors, their ligand heregulin, and the two different signaling pathways p38 and mitogen-activated protein kinase (MAPK), as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06033cc3acb0a9bd9d2ee99f62c8de9c
https://doi.org/10.1007/bf03032345
https://doi.org/10.1007/bf03032345
Autor:
R, Pinkas-Kramarski, M, Shelly, B C, Guarino, L M, Wang, L, Lyass, I, Alroy, M, Alimandi, A, Kuo, J D, Moyer, S, Lavi, M, Eisenstein, B J, Ratzkin, R, Seger, S S, Bacus, J H, Pierce, G C, Andrews, Y, Yarden, M, Alamandi
Publikováno v:
Molecular and Cellular Biology. 18:6090-6101
The recently isolated second family of neuregulins, NRG2, shares its primary receptors, ErbB-3 and ErbB-4, and induction of mammary cell differentiation with NRG1 isoforms, suggesting functional redundancy of the two growth factor families. To addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946ed62531a2d336bcf0f428a95c6979
https://doi.org/10.1128/mcb.18.10.6090
https://doi.org/10.1128/mcb.18.10.6090
Autor:
Michael Sela, E.J.J. van Zoelen, S. S. Bacus, E Tzahar, Yosef Yarden, Ronit Pinkas-Kramarski, Anne E.G. Lenferink, Leah N. Klapper, Ljuba Lyass, M.L.M. van de Poll
Publikováno v:
Oncogene, 16, pp. 1249-1258
Oncogene, 16, 1249-1258
Oncogene, 16, 1249-1258
The ErbB-1 receptor tyrosine kinase binds to six different growth factors, whose prototype is the epidermal growth factor (EGF). Two homologous epithelial receptors, ErbB-3 and ErbB-4, bind all isoforms of another family of growth factors, the Neu di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663db974fd96966789708f19e91f8940
https://doi.org/10.1038/sj.onc.1201642
https://doi.org/10.1038/sj.onc.1201642
Publikováno v:
British Journal of Cancer
Amplification and overexpression of the erbB-2 oncogene is an unfavourable prognostic marker in human breast cancer and occurs in approximately 25% of breast carcinomas. We used erbB-2 antisense oligonucleotides to inhibit the proliferation of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e5e7e9d97a2780f199239b659d1762
https://doi.org/10.1038/bjc.1994.405
https://doi.org/10.1038/bjc.1994.405
Comparison of the Papanicolaou and Feulgen staining methods for DNA quantification by image analysis
Publikováno v:
Cytometry. 11:468-474
The possibility of using archival cytology material to study the evolution of neoplastic disease with regard to DNA content abnormalities was investigated. The accuracy of measuring the integrity optical density (OD) of nuclei that correlates to DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f3620ad19b414427ee35c4576a73e
https://doi.org/10.1002/cyto.990110404
https://doi.org/10.1002/cyto.990110404
Autor:
Terry L. Smith, Gabriel N. Hortobagyi, Rita Nahta, S. S. Bacus, Francisco J. Esteva, Ying Yang, Lajos Pusztai, Thomas A. Buchholz, Aysegul A. Sahin, Aman U. Buzdar
Publikováno v:
Cancer. 100(3)
BACKGROUND Chemotherapy-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation reportedly leads to increased apoptosis in breast carcinoma cells. The goals of the current study were to assess the incidence of activated phosphorylated p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292c196f8eda8fd649c96f0b80ab6e7f
https://pubmed.ncbi.nlm.nih.gov/14745865
https://pubmed.ncbi.nlm.nih.gov/14745865
Publikováno v:
Cancer research. 57(23)
DNA damage leads to the stabilization of p53 protein and its translocation to the nucleus, resulting in activation or suppression of p53-responsive genes. However, a significant proportion of cell nuclei remain negative for p53 and p53-inducible cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc503af884dc5af3ab0a64fb6289fcd3
https://pubmed.ncbi.nlm.nih.gov/9393737
https://pubmed.ncbi.nlm.nih.gov/9393737
Autor:
S S, Bacus, Y, Yarden, M, Oren, D M, Chin, L, Lyass, C R, Zelnick, A, Kazarov, W, Toyofuku, J, Gray-Bablin, R R, Beerli, N E, Hynes, M, Nikiforov, R, Haffner, A, Gudkov, K, Keyomarsi
Publikováno v:
Oncogene. 12(12)
Previously we reported that neu differentiation factor (NDF)/heregulin (HRG) elevates tyrosine phosphorylation of its receptors erbB-3, erbB-4, and erbB-2 (through heterodimer formation). We also showed that both NDF/HRG and antibodies to erbB-2 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79408c1355449c1417d1b353343732e7
https://pubmed.ncbi.nlm.nih.gov/8700512
https://pubmed.ncbi.nlm.nih.gov/8700512
Publikováno v:
Cancer research. 55(17)
The amplification and overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, have been observed frequently in tumors from human breast cancer patients and are correlated with poor prognosis. To explore the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38591c0bbc47dec2ebb4d01289a7410f
https://pubmed.ncbi.nlm.nih.gov/7543819
https://pubmed.ncbi.nlm.nih.gov/7543819