Zobrazeno 1 - 10
of 238
pro vyhledávání: '"S. Reader"'
Autor:
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110227- (2022)
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector
Externí odkaz:
https://doaj.org/article/4cdf1de664b34a7d9beec6238fad7a6b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The cardiovascular system can sense and adapt to changes in mechanical stimuli by remodeling the physical properties of the heart and blood vessels in order to maintain homeostasis. Imbalances in mechanical forces and/or impaired sensing are now not
Externí odkaz:
https://doaj.org/article/bc6e795fd0424cc68b30c544c4fe215a
Autor:
Timothy A. Yap, Patricia M. LoRusso, Deborah J. Wong, Siwen Hu-Lieskovan, Kyriakos P. Papadopoulos, Josefin-Beate Holz, Urszula Grabowska, Cristian Gradinaru, Kin-Mei Leung, Sylwia Marshall, Claire S. Reader, Roslin Russell, Richard C.A. Sainson, Claire J. Seal, Christopher J. Shepherd, Fiona Germaschewski, Daniel Gliddon, Omer Stern, Lesley Young, Neil Brewis, Louis Kayitalire, Michelle Morrow
Publikováno v:
Clinical Cancer Research. 29:888-898
Purpose:This phase 1 study (NCT03440437) evaluated the safety, tolerability, pharmacokinetics (PK), and activity of FS118, a bispecific antibody–targeting LAG-3 and PD-L1, in patients with advanced cancer resistant to anti–PD-(L)1 therapy.Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9870f3d61f3370620b11f3584de2d6c4
https://doi.org/10.1158/1078-0432.ccr-22-1449
https://doi.org/10.1158/1078-0432.ccr-22-1449
Autor:
Michelle Morrow, Louis Kayitalire, Neil Brewis, Lesley Young, Omer Stern, Daniel Gliddon, Fiona Germaschewski, Christopher J. Shepherd, Claire J. Seal, Richard C.A. Sainson, Roslin Russell, Claire S. Reader, Sylwia Marshall, Kin-Mei Leung, Cristian Gradinaru, Urszula Grabowska, Josefin-Beate Holz, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Deborah J. Wong, Patricia M. LoRusso, Timothy A. Yap
Supplementary information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b184e3f77517649b8130a606ef0a05
https://doi.org/10.1158/1078-0432.22489943
https://doi.org/10.1158/1078-0432.22489943
Autor:
Michelle Morrow, Louis Kayitalire, Neil Brewis, Lesley Young, Omer Stern, Daniel Gliddon, Fiona Germaschewski, Christopher J. Shepherd, Claire J. Seal, Richard C.A. Sainson, Roslin Russell, Claire S. Reader, Sylwia Marshall, Kin-Mei Leung, Cristian Gradinaru, Urszula Grabowska, Josefin-Beate Holz, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Deborah J. Wong, Patricia M. LoRusso, Timothy A. Yap
Supplementary Figure S1: Study design for the evaluation of FS118 in subjects with advanced solid tumors whoprogressed on or after prior PD-(L)1 therapy.Supplementary Figure S2: Time on FS118 treatment in patients with primary or acquired resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b19bd1e4fc2bc411e31a1ea30e2ba5
https://doi.org/10.1158/1078-0432.22489946.v1
https://doi.org/10.1158/1078-0432.22489946.v1
Autor:
Michelle Morrow, Louis Kayitalire, Neil Brewis, Lesley Young, Omer Stern, Daniel Gliddon, Fiona Germaschewski, Christopher J. Shepherd, Claire J. Seal, Richard C.A. Sainson, Roslin Russell, Claire S. Reader, Sylwia Marshall, Kin-Mei Leung, Cristian Gradinaru, Urszula Grabowska, Josefin-Beate Holz, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Deborah J. Wong, Patricia M. LoRusso, Timothy A. Yap
Purpose:This phase 1 study (NCT03440437) evaluated the safety, tolerability, pharmacokinetics (PK), and activity of FS118, a bispecific antibody–targeting LAG-3 and PD-L1, in patients with advanced cancer resistant to anti–PD-(L)1 therapy.Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08ea5484c59f0d44d3a336fb85f05b3
https://doi.org/10.1158/1078-0432.c.6533066
https://doi.org/10.1158/1078-0432.c.6533066
Autor:
Michelle Morrow, Louis Kayitalire, Neil Brewis, Lesley Young, Omer Stern, Daniel Gliddon, Fiona Germaschewski, Christopher J. Shepherd, Claire J. Seal, Richard C.A. Sainson, Roslin Russell, Claire S. Reader, Sylwia Marshall, Kin-Mei Leung, Cristian Gradinaru, Urszula Grabowska, Josefin-Beate Holz, Kyriakos P. Papadopoulos, Siwen Hu-Lieskovan, Deborah J. Wong, Patricia M. LoRusso, Timothy A. Yap
Supplementary Table S1: Representativeness of Study Participants.Supplementary Table S2: Immunogenicity in patients treated with FS118.Supplementary Table S3: PK of FS118 by Dose Level.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e7c2e048ad7d481d58db7e5f5c9dae
https://doi.org/10.1158/1078-0432.22489940
https://doi.org/10.1158/1078-0432.22489940
Publikováno v:
Cells, Vol 9, Iss 3, p 650 (2020)
Mechanical forces acting on biological systems, at both the macroscopic and microscopic levels, play an important part in shaping cellular phenotypes. There is a growing realization that biomolecules that respond to force directly applied to them, or
Externí odkaz:
https://doaj.org/article/b9c852af91ae4b87a60d13e5b8a94f62
Publikováno v:
Current Opinion in Physiology. 34:100673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85931c7b7f6f72ecbf995263710f6601
https://doi.org/10.1016/j.cophys.2023.100673
https://doi.org/10.1016/j.cophys.2023.100673
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