Zobrazeno 1 - 9
of 9
pro vyhledávání: '"S. R. Biggs"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 10:209-215
Humans excreted an oral dose of 5 mg of the anti-depressant lortalamine (radiolabelled with carbon-14) mainly in the urine (98% during 5 days). Plasma 14C concentrations were highest (about 44 ng equiv./ml) between 1.5-3 h when the corresponding conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8635ce6653a8e70003d5c3da633612a1
https://doi.org/10.1007/bf03189744
https://doi.org/10.1007/bf03189744
Publikováno v:
Journal of Pharmacy and Pharmacology. 34:299-303
The major urine metabolites of the neuroleptic drug, bromperidol, after oral doses to rats and dogs are p-fluorophenylacetic acid and its glycine conjugate resulting from oxidative N-dealkylation. While the same metabolites were also detected in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ecf88fb5fd7512c7ab6e545a1b1ca9
https://doi.org/10.1111/j.2042-7158.1982.tb04711.x
https://doi.org/10.1111/j.2042-7158.1982.tb04711.x
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 7(4)
A high-performance liquid chromatographic method for the routine, simultaneous determination of amitriptyline and its basic metabolites in human urine has been developed. 10-Hydroxylated metabolites are analyzed as their 10,11-dehydro analogs, and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59c0665c39a2bb9c8776d66f4e8b8f66
https://pubmed.ncbi.nlm.nih.gov/39726
https://pubmed.ncbi.nlm.nih.gov/39726
Autor:
A. J. S. Jackson, S. G. Wood, A. Darragh, D. Kirkpatrick, S. R. Biggs, Chasseaud Lf, D. R. Hawkins, W. H. Down
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 12(3)
1. Single oral doses of the hypolipidaemic drug [35S]sultosilic acid to rats (40 mg/kg), dogs (40 mg/kg) and man (7 mg/kg) were well absorbed. During three days, means of 59.2%, 58.8% and 61.8% in urine and 37.7%, 31.9% and 19.7% in faeces, were excr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c22e1d72f1e1a91b001541c67e24c4
https://pubmed.ncbi.nlm.nih.gov/7113253
https://pubmed.ncbi.nlm.nih.gov/7113253
Publikováno v:
Journal of pharmacobio-dynamics. 5(12)
During 5d following single oral doses of 3H-11-bromovincamine to rats (10 mg/kg), dogs (10 mg/kg) and humans (0.5 mg/kg), about 21 and 66%, 28 and 56% and 64 and 21% of the dose were excreted in the urine and faeces respectively, mainly within 24 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8485fe09747aff6903c6b97b8c2783
https://pubmed.ncbi.nlm.nih.gov/7169608
https://pubmed.ncbi.nlm.nih.gov/7169608
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 10(12)
1. Single oral doses of the anticholinergic drug [14C]Sormodren to rats (1 mg/kg), dogs (0.3 mg/kg) and humans (0.03 mg/kg) were well absorbed. Excreted in urine and faeces were means of 31 and 70%, 53 and 39%, and 78 and 4% in rats, dogs, and humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a9ae3ae927d86cc36d1559af364967
https://pubmed.ncbi.nlm.nih.gov/7210700
https://pubmed.ncbi.nlm.nih.gov/7210700
Autor:
S. G. Wood, I Johnstone, J G Priego, R F Lambe, A. Darragh, L. F. Chasseaud, B. A. John, S. R. Biggs, D. R. Hawkins
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 13(12)
Oral doses of 14C-eterylate were well absorbed by rat and man and excreted mainly in the urine (94% dose by rat in three days and 91% by man in five days). Oral doses to dogs were excreted in similar proportions in both the urine and faeces, although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2f312420b4410811eb8ffd207166cf
https://pubmed.ncbi.nlm.nih.gov/6144210
https://pubmed.ncbi.nlm.nih.gov/6144210
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 10(3)
During 5 days following a single oral dose of 3H-11-bromovincamine (40 mg) to two human subjects, means of 55% and 27% of the 3H dose were excreted in the urine and faeces respectively, mainly within 24 and 48 h. Mean plasma concentrations of 3H reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bb2113234181b484024bb814036a09
https://pubmed.ncbi.nlm.nih.gov/4085521
https://pubmed.ncbi.nlm.nih.gov/4085521
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 5(4)
Buprenorphine is a newly-developed strong analgesic. A selected ion monitoring method has been developed to measure its plasma levels over the concentration range 20-3000ng ml-1. Six baboons each received intravenous and intramuscular doses of bupren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdb78c86b31f38b3402583b5fab0f26
https://pubmed.ncbi.nlm.nih.gov/7250147
https://pubmed.ncbi.nlm.nih.gov/7250147