Zobrazeno 1 - 10
of 101
pro vyhledávání: '"S. Priestley"'
Publikováno v:
Geoscientific Instrumentation, Methods and Data Systems, Vol 13, Pp 117-129 (2024)
Understanding when and why groundwater recharge occurs is of fundamental importance for the sustainable use of this essential freshwater resource for humans and ecosystems. However, accurately capturing this component of the water balance is widely a
Externí odkaz:
https://doaj.org/article/859edb6d0cd44cc8b3dc5140deec522a
Autor:
Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which
Externí odkaz:
https://doaj.org/article/53df786506df4fffaf54431621d57eba
Autor:
Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to impro
Externí odkaz:
https://doaj.org/article/2c4f99fc24ed49b8a965b629b176459d
Autor:
L.M. Mosley, S. Priestley, J. Brookes, S. Dittmann, J. Farkaš, M. Farrell, A.J. Ferguson, M. Gibbs, M. Hipsey, J. Huang, O. Lam-Gordillo, S.L. Simpson, J.J. Tyler, M. Waycott, D.T. Welsh
Refereed/Peer-reviewed Estuaries in rainfall poor regions are highly susceptible to climatic and hydrological changes. The Coorong, a Ramsar-listed estuarine-coastal lagoon at the end of the Murray-Darling Basin (Australia), has experienced declining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9657bf90c87ea4fef0416bf385f584a4
https://hdl.handle.net/11541.2/32702
https://hdl.handle.net/11541.2/32702
Akademický článek
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Akademický článek
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Autor:
Michael H. L. Wong, Paul M. O'Neill, Piyaporn Jirawatcharadech, Pietro Alano, Giancarlo A. Biagini, Sangeeta N. Bhatia, Grazia Camarda, Alex B. Miller, Mark J. I. Paine, Suet C. Leung, David A. Baker, Stephen A. Ward, Richard S. Priestley, Sandra March, Ahmed Saif
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70 years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ metabolites (OH-PQm) are responsible for efficacy against liver and sexual trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa2fd4f7d43fe26979b7416f3219152
http://link.springer.com/article/10.1038/s41467-019-11239-0
http://link.springer.com/article/10.1038/s41467-019-11239-0
Autor:
Richard S. Priestley, Emma Mead, William Bradshaw, John B. Davis, Hazel Hall Roberts, Elena Di Daniel, Carmen Jimenez-Antunez, Sally A. Cowley, Opher Gileadi, Juliane Obst
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c536f7f0de1ab9092a40eaa12a39ae9
https://doi.org/10.1002/alz.045839
https://doi.org/10.1002/alz.045839
Autor:
Richard S. Priestley, Giancarlo A. Biagini, Paul M. O'Neill, Kangsa Amporndanai, Jill Davies, W. David Hong, Gemma L. Nixon, Svetlana V. Antonyuk, Stephen A. Ward, Suet C. Leung, S. Samar Hasnain, Neil G. Berry
Publikováno v:
ACS Medicinal Chemistry Letters
[Image: see text] A series of 2-pyrazolyl quinolones has been designed and synthesized in 5–7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1e1ed03122835c304452b49c545bff
https://doi.org/10.1021/acsmedchemlett.8b00371
https://doi.org/10.1021/acsmedchemlett.8b00371
Publikováno v:
The FASEB Journal. 29:1446-1455
Cannabinoids are reported to have actions through peroxisome proliferator-activated receptors (PPARs), which led us to investigate PPAR agonists for activity at the cannabinoid receptors. Radio-ligand binding and functional assays were conducted usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68b6dbee1ea570e62ec6f697c45a30e
https://doi.org/10.1096/fj.14-263053
https://doi.org/10.1096/fj.14-263053