Crystal structure of phosphomannose isomerase fromCandida albicanscomplexed with 5‐phospho‐d‐arabinonhydrazide

Autor: Herman van Tilbeurgh, Lama Ahmad, Inès Li de la Sierra-Gallay, Noureddine Lazar, S. Plancqueel, Wadih Ghattas, Virginie Dubosclard, Laurent Salmon

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2018, 592 (10), pp.1667--1680. ⟨10.1002/1873-3468.13059⟩
FEBS Letters, 2018, 592 (10), pp.1667--1680. ⟨10.1002/1873-3468.13059⟩

International audience; Type I phosphomannose isomerases (PMIs) are zinc-dependent monofunctional metalloenzymes catalysing the reversible isomerization of d-mannose 6-phosphate to d-fructose 6-phosphate. 5-Phospho-d-arabinonhydrazide (5PAHz), design

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3185d98452e04dec11c6591cfe356955
https://doi.org/10.1002/1873-3468.13059

Novel N-substituted 5-phosphate-d-arabinonamide derivatives as strong inhibitors of phosphoglucose isomerases: Synthesis, structure-activity relationship and crystallographic studies

Autor: Herman van Tilbeurgh, S. Plancqueel, Lama Ahmad, Laurent Salmon, Noureddine Lazar, Hafsa Korri-Youssoufi, Inès Li de la Sierra-Gallay

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, 2020, 102, pp.104048. ⟨10.1016/j.bioorg.2020.104048⟩
Bioorganic Chemistry, Elsevier, 2020, 102, pp.104048. ⟨10.1016/j.bioorg.2020.104048⟩

International audience; Phosphoglucose isomerase (PGI) is a cytosolic enzyme that catalyzes the reversible interconversion of d-glucose 6-phosphate and d-fructose 6-phosphate in glycolysis. Outside the cell, PGI is also known as autocrine motility fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2b249f4c981ade729a73bdd3744080
https://doi.org/10.1016/j.bioorg.2020.104048

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The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification.

Autor: Missoury S; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Plancqueel S; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Li de la Sierra-Gallay I; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Zhang W; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Liger D; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Durand D; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Dammak R; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France., Collinet B; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France.; Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, UMR7590 CNRS/Sorbonne-Université, UPMC, Paris, France., van Tilbeurgh H; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR 9198, Univ. Paris-Sud, Université Paris-Saclay, 91198 Gif sur Yvette Cedex, France.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2019 Sep 26; Vol. 47 (17), pp. 9464-9465.