Zobrazeno 1 - 7
of 7
pro vyhledávání: '"S. Paul Jones"'
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Autor:
S. Paul Jones, James D. Firth, Mary C. Wheldon, Masakazu Atobe, Roderick E. Hubbard, David C. Blakemore, Claudia De Fusco, Simon C. C. Lucas, Stephen D. Roughley, Lewis R. Vidler, Maria Ann Whatton, Alison J.-A. Woolford, Gail L. Wrigley, Peter O'Brien
Publikováno v:
RSC medicinal chemistry. 13(12)
Fragment-based drug discovery is now widely adopted for lead generation in the pharmaceutical industry. However, fragment screening collections are often predominantly populated with flat, 2D molecules. Herein, we report the synthesis of piperidine-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506a35ff9f31d56c1344c52cbe76d494
https://pubmed.ncbi.nlm.nih.gov/36545433
https://pubmed.ncbi.nlm.nih.gov/36545433
Autor:
Peter O'Brien, C. David Owen, Alice Douangamath, Louise Dunnett, Efrat Resnick, Mathew P. Martin, P. Gehrtz, R. Skyner, José Brandão-Neto, Nir London, Martin A. Walsh, Petra Lukacik, S. Paul Jones, Péter Ábrányi-Balogh, James D. Firth, M. Snee, Rambabu N. Reddi, Anna Carbery, D. Fearon, Aaron Keeley, Hanna F. Klein, T. Krojer, Gemma Davison, Frank von Delft, Conor Wild, Michael J. Waring, A.J. Powell, Martin E.M. Noble, G.M. Keseru, Claire Strain-Damerell, A. Aimon, Thomas D. Downes, Alexandre Dias, Michael Fairhead
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0901607193d626009824417763fb3128
https://doi.org/10.1101/2020.05.27.118117
https://doi.org/10.1101/2020.05.27.118117
Autor:
Alison Jo-Anne Woolford, Stephen D. Roughley, Paul S. Bond, Ngai S. Chan, Mary C. Wheldon, S. Paul Jones, Hanna F. Klein, Peter O'Brien, James D. Firth, Masakazu Atobe, Lewis R. Vidler, David C. Blakemore, Roderick E. Hubbard, Claudia De Fusco, Laura Waddelove, Gail L. Wrigley, Thomas D. Downes, Maria Ann Whatton
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Fragment‐based drug discovery is now widely adopted for lead generation in the pharmaceutical industry. However, fragment screening collections are often predominantly populated with flat, 2D molecules. Herein, we describe a workflow for the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b75d3323a5d705c7a989e362d556a27
https://pubmed.ncbi.nlm.nih.gov/32315100
https://pubmed.ncbi.nlm.nih.gov/32315100
Publikováno v:
IEEE Transactions on Industry Applications. :882-888
A method is described for evaluating the life of cable insulation subjected to the varying temperature and time electrical service conditions of a locomotive. This type of evaluation becomes more important as the current ratings of higher fuel effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d290856512bc35dd316ee652129721
https://doi.org/10.1109/tia.1985.349536
https://doi.org/10.1109/tia.1985.349536
Autor:
S. Paul Jones
Publikováno v:
Symposium: A Quarterly Journal in Modern Literatures. 4:433-435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e7fa668731813b346d5e51d7658dd9a
https://doi.org/10.1080/00397709.1950.10732337
https://doi.org/10.1080/00397709.1950.10732337
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