Výsledky vyhledávání - "S. Patricia Becerra"

Akademický článek

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

Autor: Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, Richard S. Brush, Martin-Paul Agbaga, S. Patricia Becerra

Publikováno v: Journal of Lipid Research, Vol 64, Iss 5, Pp 100358- (2023)

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophi

Externí odkaz: https://doaj.org/article/e6edfbfcaeb9463cb8396dbeb2decb19

Zobrazit plný text záznamu

Akademický článek

Pigment epithelium-derived factor is an interleukin-6 antagonist in the RPE: Insight of structure-function relationships

Autor: Alexandra Bernardo-Colón, Miriam Lerner, S. Patricia Becerra

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of I

Externí odkaz: https://doaj.org/article/83d777ab535646b0b164fe11e7a88838

Zobrazit plný text záznamu

Akademický článek

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Autor: Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 13, Pp n/a-n/a (2021)

Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD pro

Externí odkaz: https://doaj.org/article/f4461325f8d6451f97d6779225925a12

Zobrazit plný text záznamu

Akademický článek

Cell-based assays to identify novel retinoprotective agents

Autor: Jeanee Bullock, Glorivee Pagan-Mercado, S. Patricia Becerra

Publikováno v: MethodsX, Vol 7, Iss , Pp 101026- (2020)

Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration. Quantitative cell-base

Externí odkaz: https://doaj.org/article/b5bc1149dc11466a8a44d7ecfb06b6bb

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání