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Autor:
Meghan Collins, Ruggiero Gorgoglione, Valeria Impedovo, Xingxin Pan, Sathyaseelan Chakkarai, S. Stephen Yi, Alessia Lodi, Stefano Tiziani
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Background and aimsAberrations in the immunoglobulin heavy chain (IgH) locus are associated with poor prognosis in pediatric precursor B-cell acute lymphoblastic leukemia (BCP-ALL) patients. The primary objective of this pilot study is to enhance our
Externí odkaz:
https://doaj.org/article/3be38ee58bba47608984c83aa621a49e
Autor:
Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M. Guerrero, Nicholas A. Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S. Stephen Yi, Ken Chen, Daniel J. McGrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CR
Externí odkaz:
https://doaj.org/article/40cc73e86a42414c8dbcd229f50f5fe6
Autor:
Swarnendu Tripathi, Hazheen K. Shirnekhi, Scott D. Gorman, Bappaditya Chandra, David W. Baggett, Cheon-Gil Park, Ramiz Somjee, Benjamin Lang, Seyed Mohammad Hadi Hosseini, Brittany J. Pioso, Yongsheng Li, Ilaria Iacobucci, Qingsong Gao, Michael N. Edmonson, Stephen V. Rice, Xin Zhou, John Bollinger, Diana M. Mitrea, Michael R. White, Daniel J. McGrail, Daniel F. Jarosz, S. Stephen Yi, M. Madan Babu, Charles G. Mullighan, Jinghui Zhang, Nidhi Sahni, Richard W. Kriwacki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular c
Externí odkaz:
https://doaj.org/article/8f35cd376f7a48a1b2f93578aa021be6
Autor:
Fushun Wang, Wei Wang, Simeng Gu, Dan Qi, Nathan A. Smith, Weiguo Peng, Wei Dong, Jiajin Yuan, Binbin Zhao, Ying Mao, Peng Cao, Qing Richard Lu, Lee A. Shapiro, S. Stephen Yi, Erxi Wu, Jason H. Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Despite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell rec
Externí odkaz:
https://doaj.org/article/64660405c12e4785a602c29e47963d5e
Autor:
Xingxin Pan, Jun Yun, Zeynep H. Coban Akdemir, Xiaoqian Jiang, Erxi Wu, Jason H. Huang, Nidhi Sahni, S. Stephen Yi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1533-1542 (2023)
Discovering effective therapies is difficult for neurological and developmental disorders in that disease progression is often associated with a complex and interactive mechanism. Over the past few decades, few drugs have been identified for treating
Externí odkaz:
https://doaj.org/article/20a864aabc5f4043b0ac3a7f59d4f919
Autor:
Dan Qi, Yiqun Geng, Jacob Cardenas, Jinghua Gu, S. Stephen Yi, Jason H. Huang, Ekokobe Fonkem, Erxi Wu
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Peripheral blood is gaining prominence as a noninvasive alternative to tissue biopsy to develop biomarkers for glioblastoma (GBM); however, widely utilized blood-based biomarkers in clinical settings have not yet been identified due to the l
Externí odkaz:
https://doaj.org/article/2c57a57891044956bca3ec4bc011a2a7
Autor:
David R. Amici, Harun Cingoz, Milad J. Alasady, Sammy Alhayek, Claire M. Phoumyvong, Nidhi Sahni, S. Stephen Yi, Marc L. Mendillo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The recently described protein HAPSTR1 governs cellular stress resilience. Here, the authors discover a mammalian HAPSTR1 paralog, called HAPSTR2, which formed via retro-transposition and operates to augment and buffer cellular stress signaling.
Externí odkaz:
https://doaj.org/article/2fa718e81372480a8c04b9cdbbe10970
Publikováno v:
Journal of Applied Fluid Mechanics, Vol 15, Iss 1, Pp 63-72 (2022)
The cooling effectiveness of optical window influences the imaging quality of hypersonic vehicles. This study focuses on the supersonic film cooling efficiency on the optical window of a blunt cone in hypersonic flow. The experiments were conducted i
Externí odkaz:
https://doaj.org/article/008c5df9afa34b029de86be61cdc5493
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3511-3521 (2022)
Effective and precise classification of glioma patients for their disease risks is critical to improving early diagnosis and patient survival. In the recent past, a significant amount of multi-omics data derived from cancer patients has emerged. Howe
Externí odkaz:
https://doaj.org/article/e31fa03c2a8d43c1ac702b2f9c856c22