Zobrazeno 1 - 10 of 16 pro vyhledávání: '"S. P. Squinto"'
1
A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex
Autor: W L Fodor, S A Rollins, E R Guilmette, E Setter, S P Squinto
Publikováno v: The Journal of Immunology. 155:4135-4138
Human cells express cell surface complement regulatory molecules that inhibit the activity of the C3/C5 convertases (DAF, MCP, CR1) or inhibit the membrane attack complex (CD59). A single molecule that inhibits both the convertase activity and format
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c74f99103092d34096e7732e4f70f4a0
https://doi.org/10.4049/jimmunol.155.9.4135
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2
Engineering of Xenografts To Provide Organs for Human Transplantation
Autor: S. P. Squinto, W. L. Fodor
Publikováno v: Xenotransplantation ISBN: 9783642644603
Transplantation is clearly the treatment of choice for most patients suffering from end-stage organ failure. Significant progress in clinical allotransplantation has been achieved during the past decade. These pharmacological and surgical achievement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f1c2cea2aa00a76346690aa431c688b
https://doi.org/10.1007/978-3-642-60572-7_48
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3
Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model
Autor: T J, Kroshus, R M, Bolman, A P, Dalmasso, S A, Rollins, E R, Guilmette, B L, Williams, S P, Squinto, W L, Fodor
Publikováno v: Transplantation. 61(10)
The serious shortage of available donor organs for patients with end stage organ failure who are in need of solid organ transplantation has led to a heightened interest in xenotransplantation. The major barrier to successful discordant xenotransplant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e6f5637bce4c0ac6eb14b1d98cc66a6
https://pubmed.ncbi.nlm.nih.gov/8633381
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6
Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation
Autor: T J, Kroshus, S A, Rollins, A P, Dalmasso, E A, Elliott, L A, Matis, S P, Squinto, R M, Bolman
Publikováno v: Transplantation. 60(11)
Prevention of hyperacute xenograft rejection in the pig-to-primate combination has been accomplished by removal of natural antibodies, complement depletion with cobra venom factor, or prevention of C3 activation with the soluble complement inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac7cb411e008cc9282ada0c49abb29db
https://pubmed.ncbi.nlm.nih.gov/8525509
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7
A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex
Autor: W L, Fodor, S A, Rollins, E R, Guilmette, E, Setter, S P, Squinto
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(9)
Human cells express cell surface complement regulatory molecules that inhibit the activity of the C3/C5 convertases (DAF, MCP, CR1) or inhibit the membrane attack complex (CD59). A single molecule that inhibits both the convertase activity and format
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f32cba040b0af58e3b4b45486238505e
https://pubmed.ncbi.nlm.nih.gov/7594566
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8
The ENCEL system: a somatic cell protein delivery system
Autor: S P, Squinto, J A, Madri, S, Kennedy, J, Springhorn
Publikováno v: In vivo (Athens, Greece). 8(5)
A wide variety of somatic cells are being explored for the introduction of foreign genes with a view toward gene therapy. A prime requirement for successful gene therapy is the sustained expression, effective dosing, and systemic delivery of the ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::293c8419fbca1d280d391b2ea4bbdda6
https://pubmed.ncbi.nlm.nih.gov/7727724
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9
Expression of recombinant transmembrane CD59 in paroxysmal nocturnal hemoglobinuria B cells confers resistance to human complement
Autor: R P, Rother, S A, Rollins, J, Mennone, A, Chodera, S A, Fidel, M, Bessler, P, Hillmen, S P, Squinto
Publikováno v: Blood. 84(8)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic disorder characterized by complement-mediated hemolytic anemia, pancytopenia, and venous thrombosis. These clinical manifestations arise from an underlying molecular defect of bon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::690a42d698c56525a9ea7b589623c7f5
https://pubmed.ncbi.nlm.nih.gov/7522635
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10
Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59
Autor: S P, Kennedy, S A, Rollins, W V, Burton, P J, Sims, A L, Bothwell, S P, Squinto, G B, Zavoico
Publikováno v: Transplantation. 57(10)
Discordant xenogeneic organ transplantation is a potential solution to the critical shortage of suitable donor organs. However, clinical application of xenotransplantation with physiologically suitable organs such as those from the pig, is currently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db2c9bf10fe85657e37744813bac4e84
https://pubmed.ncbi.nlm.nih.gov/7515200
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