Zobrazeno 1 - 10
of 80
pro vyhledávání: '"S. P. Chao"'
Autor:
Kevin Chih-Yang Huang, William Tzu-Liang Chen, Jia-Yi Chen, Chien-Yueh Lee, Chia-Hsin Wu, Chia-Ying Lai, Pei-Chen Yang, Ji-An Liang, An‑Cheng Shiau, K. S. Clifford Chao, Tao-Wei Ke
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Although irradiated induced-pluripotent stem cells (iPSCs) as a prophylactic cancer vaccine elicit an antitumor immune response, the therapeutic efficacy of iPSC-based cancer vaccines is not promising due to their insufficient antigenicity a
Externí odkaz:
https://doaj.org/article/f7f837b5bb3344b482c12fb402089cc0
Autor:
Kevin Chih-Yang Huang, Shu-Fen Chiang, Pei-Chun Lin, Wei-Ze Hong, Pei-Chen Yang, Hui-Ping Chang, Shin-Lei Peng, Tsung-Wei Chen, Tao-Wei Ke, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα-mediated PANX1 cleavage was essential for ATP release in response to chemother
Externí odkaz:
https://doaj.org/article/9b94d1b51f6c4247a382ea20f1a4efd8
Autor:
Ji-An Liang, Hsin-Yu Chang, Kevin Chih-Yang Huang, Shu-Fen Chiang, Wei-Ze Hong, Jhen-Yu Chen, Pei-Chih Lee, Tao-Wei Ke, Shin-Lei Peng, An‑Cheng Shiau, Tsung-Wei Chen, Pei-Chen Yang, William Tzu-Liang Chen, K S Clifford Chao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Cancer-intrinsic type I interferon (IFN-I) production triggered by radiotherapy (RT) is mainly dependent on cytosolic double-stranded DNA (dsDNA)-mediated cGAS/STING signaling and increases cancer immunogenicity and enhances the antitumor
Externí odkaz:
https://doaj.org/article/04f35a576e1d4e42ae0eae914b4b76f6
Autor:
Kevin Chih-Yang Huang, Tao-Wei Ke, Jia-Yi Chen, Wei-Ze Hong, Shu-Fen Chiang, Chia-Ying Lai, Tsung-Wei Chen, Pei-Chen Yang, Liang-Chi Chen, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Regional lymph node metastasis is an important predictor for survival outcome and an indicator for postoperative adjuvant chemotherapy in patients with colorectal cancer. Even with advances in adjuvant chemotherapeutic regimens, 5-year dista
Externí odkaz:
https://doaj.org/article/805466ca437449f18933c47295fdf9dd
Autor:
Kevin Chih-Yang Huang, Shu-Fen Chiang, Hsin-Yu Chang, William Tzu-Liang Chen, Pei-Chen Yang, Tsung-Wei Chen, Ji-An Liang, An‑Cheng Shiau, Tao-Wei Ke, K. S. Clifford Chao
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-12 (2022)
Abstract Radiotherapy (RT) mainly elicits antitumor immunity via the cGAS/STING axis for type I interferon (IFN) production. However, dysregulation of cGAS/STING constrains radiotherapy-induced antitumor immunity and type I IFN-dependent cell death a
Externí odkaz:
https://doaj.org/article/30fde6c7ddcd43b5a24c83e8815e09b7
Autor:
Yu-Ting Yen, May Chien, Pei-Yi Wu, Chi-Chang Ho, Chun-Te Ho, Kevin Chih-Yang Huang, Shu-Fen Chiang, K. S. Clifford Chao, William Tzu-Liang Chen, Shih-Chieh Hung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB). Here the authors show that inactivation of protein phosphatase 2A induces a MSI
Externí odkaz:
https://doaj.org/article/ee5d373d4c714baf8fcd6599a08ef1f1
Autor:
Alexander M. Loiben, Wei-Ming Chien, Clayton E. Friedman, Leslie S.-L. Chao, Gerhard Weber, Alex Goldstein, Nathan J. Sniadecki, Charles E. Murry, Kai-Chun Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4909 (2023)
Missense mutations in myosin heavy chain 7 (MYH7) are a common cause of hypertrophic cardiomyopathy (HCM), but the molecular mechanisms underlying MYH7-based HCM remain unclear. In this work, we generated cardiomyocytes derived from isogenic human in
Externí odkaz:
https://doaj.org/article/ac8bc7b8c2a04aca89f9a3d270ab4ab3
Autor:
Hong-Jie Dai, Yi-Hsin Yang, Ti-Hao Wang, Yan-Jie Lin, Pin-Jou Lu, Chung-Yang Wu, Yu-Cheng Chang, You-Qian Lee, You-Chen Zhang, Yuan-Chi Hsu, Han-Hsiang Wu, Cheng-Rong Ke, Chih-Jen Huang, Yu-Tsang Wang, Sheau-Fang Yang, Kuan-Chung Hsiao, Ko-Jiunn Liu, Li-Tzong Chen, I-Shou Chang, K. S. Clifford Chao, Tsang-Wu Liu
Publikováno v:
IEEE Access, Vol 9, Pp 112081-112096 (2021)
Cancer registries are critical databases for cancer research whose maintenance requires various types of domain knowledge with labor-intensive data curation. In order to facilitate the curation process with high quality in a timely manner, we develop
Externí odkaz:
https://doaj.org/article/eced4a6f45294384a9d0954e5b72153c
Autor:
Kevin Chih-Yang Huang, Shu-Fen Chiang, Tsung-Wei Chen, William Tzu-Liang Chen, Pei-Chen Yang, Tao-Wei Ke, K. S. Clifford Chao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide. Although the role of tumor programmed cell death 1 ligand 1 (PD-L1) in suppressing antitumor immunity has been validated in various malignances, the impact o
Externí odkaz:
https://doaj.org/article/e8eb68cf4800457a80ce9ce67aa48863
Autor:
Shu-Fen Chiang, Kevin Chih-Yang Huang, William Tzu-Liang Chen, Tsung-Wei Chen, Tao-Wei Ke, K. S. Clifford Chao
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal can
Externí odkaz:
https://doaj.org/article/85c2a79100b6415088680bb907c0ce9b