Zobrazeno 1 - 10
of 20
pro vyhledávání: '"S. P. Arneric"'
Autor:
Roger D. Porsolt, Anthony H. Dickenson, P. S. Puttfarcken, S. P. Arneric, D. Donnelly-Roberts, A. Diaz, P. Curzon, M. W. Holladay, R. S. Bitner, M. W. Decker, A. W. Bannon, M. Williams
Publikováno v:
Science. 279:77-80
Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant = 37 picomolar) neuronal nicotinic acetylcholine receptor (nAChR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc55ed0d6b413f6f17e86d23aeed3cf
https://doi.org/10.1126/science.279.5347.77
https://doi.org/10.1126/science.279.5347.77
Autor:
N H, Lin, Y, Li, Y, He, M W, Holladay, T, Kuntzweiler, D J, Anderson, J E, Campbell, S P, Arneric
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(5)
In an effort to probe the steric influence of C5 substitution of the pyridine ring on CNS binding affinity, analogues of 1 substituted with a bulky moiety--such as phenyl, substituted phenyl, or heteroaryl-were synthesized and tested in vitro for neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dac4f20cbb36b3453501a7912a19fb20
https://pubmed.ncbi.nlm.nih.gov/11266158
https://pubmed.ncbi.nlm.nih.gov/11266158
Autor:
M. W. Holladay, S. P. Arneric
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01329e92e0454884b859b37fb3429ff1
https://doi.org/10.1007/978-3-642-57079-7_16
https://doi.org/10.1007/978-3-642-57079-7_16
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
(+/-)-Epibatidine (EPIB) and A-85380 are nicotinic acetylcholine receptor (nAChR) agonists that bind to the agonist ([3H]cytisine) binding site with 40 to 50 pM affinity but have different affinities in nAChR subtype selective functional receptor ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f51b1490ea7ebeb446f6aca5fca51a7a
https://pubmed.ncbi.nlm.nih.gov/9864263
https://pubmed.ncbi.nlm.nih.gov/9864263
Autor:
A W, Bannon, M W, Decker, P, Curzon, M J, Buckley, D J, Kim, R J, Radek, J K, Lynch, J T, Wasicak, N H, Lin, W H, Arnold, M W, Holladay, M, Williams, S P, Arneric
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(2)
The antinociceptive effects of ABT-594, a novel nicotinic acetylcholine receptor (nAChR) ligand, were examined in rats in models of acute thermal (hot box) and persistent chemical (formalin test) pain. Also, the effects of ABT-594 treatment on motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::816cf76f9dac87ae924a4fec0941ef20
https://pubmed.ncbi.nlm.nih.gov/9580627
https://pubmed.ncbi.nlm.nih.gov/9580627
Autor:
D L, Donnelly-Roberts, P S, Puttfarcken, T A, Kuntzweiler, C A, Briggs, D J, Anderson, J E, Campbell, M, Piattoni-Kaplan, D G, McKenna, J T, Wasicak, M W, Holladay, M, Williams, S P, Arneric
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(2)
The discovery of (+/-)-epibatidine, a naturally occurring neuronal nicotinic acetylcholine receptor (nAChR) agonist with antinociceptive activity 200-fold more potent than that of morphine, has renewed interest in the potential role of nAChRs in pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adaf5dde2f342fadbaeed8ff330b92ec
https://pubmed.ncbi.nlm.nih.gov/9580626
https://pubmed.ncbi.nlm.nih.gov/9580626
Autor:
J P, Sullivan, D, Donnelly-Roberts, C A, Briggs, D J, Anderson, M, Gopalakrishnan, I C, Xue, M, Piattoni-Kaplan, E, Molinari, J E, Campbell, D G, McKenna, D E, Gunn, N H, Lin, K B, Ryther, Y, He, M W, Holladay, S, Wonnacott, M, Williams, S P, Arneric
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(1)
Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes may have therapeutic utility for the treatment of several neurological disorders. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cebace127194f1e24c433b807e4f1f0e
https://pubmed.ncbi.nlm.nih.gov/9336329
https://pubmed.ncbi.nlm.nih.gov/9336329
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 37
Advances in the understanding of the molecular biology and pharmacology of nAChRs may provide targets for the development of novel and selective modulators of nAChRs in the brain. This contention is supported by the dissimilar behavioral effects obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1a945667262a67a20e37940b28a0fde
https://pubmed.ncbi.nlm.nih.gov/8891102
https://pubmed.ncbi.nlm.nih.gov/8891102
Autor:
M, Gopalakrishnan, L M, Monteggia, D J, Anderson, E J, Molinari, M, Piattoni-Kaplan, D, Donnelly-Roberts, S P, Arneric, J P, Sullivan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(1)
(-)-Nicotine, the prototypical agonist for neuronal nicotinic acetylcholine receptors (nAChR) has been shown to bind with high affinity to the rodent and avian alpha 4 beta 2 nAChR subtype. This subtype may represent a primary molecular target for so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dee169c01f7484d5676d5039626bf1f3
https://pubmed.ncbi.nlm.nih.gov/8558445
https://pubmed.ncbi.nlm.nih.gov/8558445
Autor:
D J, Anderson, M, Williams, J R, Pauly, J L, Raszkiewicz, J E, Campbell, G, Rotert, B, Surber, S B, Thomas, J, Wasicak, S P, Arneric
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(3)
ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole] is a potent and selective agonist at neuronal nicotinic acetylcholine receptors (nAChRs) with cognitive enhancing and anxiolytic activities. [3H]ABT-418 was found to bind with high affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e5bf8bc337e1bba8910cd0a7ce32ed7
https://pubmed.ncbi.nlm.nih.gov/7791118
https://pubmed.ncbi.nlm.nih.gov/7791118