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Plasma heat shock protein 90 levels in patients with spondyloarthritis and their relation to structural changes: a cross-sectional study

Autor: Maja Špiritović, Martin Komarc, Jiri Vencovsky, Marketa Husakova, J. Gatterova, Monika Gregova, Karel Pavelka, Michal Tomcik, J. Stolfa, Ladislav Šenolt, Katerina Mintalova, Jana Horinkova, S. Oreska, Kristyna Bubova, Šárka Forejtová, H Storkanova, Barbora Hermankova

Publikováno v: Biomarkers in Medicine. 15:5-13

Aim: Heat shock protein 90 (Hsp90) is a molecular chaperone regulating immune response. We aimed to assess systemic Hsp90 as a biomarker for spondyloarthritis (SpA). Materials & methods: Total of 80 axial SpA (axSpA) and 22 psoriatic arthritis patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d91d9e6d33f8b2ae7fac629f0224ebc
https://doi.org/10.2217/bmm-2020-0360

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Akademický článek

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Association of altered lipid profile with disease activity, duration, and glucocorticoid treatment in patients with idiopathic inflammatory myopathies

Autor: Michal Vrablík, S. Oreska, Jiri Vencovsky, Michal Tomcik, Karel Pavelka, H Storkanova, Barbora Hermankova, Maja Špiritović, Heřman Mann, Ladislav Šenolt

Publikováno v: European Journal of Preventive Cardiology. 28

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): AZV CR, Czech health research council MHCR, Ministry of Health Dzech republic Background Systemic inflammation, limited mobility, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eec732b4e546479fe54b36d7089be03d
https://doi.org/10.1093/eurjpc/zwab061.281

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AB0678 Subclinical Atherosclerosis and Cardiovascular Risk in Myositis Patients and Healthy Controls: Preliminary Data From a Single-center Cross-sectional Study

Autor: S. Oreska, H. Štorkánová, J. Kudlicka, V. Tuka, O. Mikeš, Z. Krupičková, M. Satny, E. Chytilova, M. Špiritović, B. Heřmánková, P. Cesak, M. Rybar, K. Pavelka, L. Šenolt, H. Mann, J. Vencovský, M. Vrablik, M. Tomčík

Publikováno v: Annals of the Rheumatic Diseases. 81:1467.1-1467

BackgroundIdiopathic inflammatory myopathies (IIM) are associated with systemic inflammation, limited mobility, and glucocorticoid (GC) therapy, which can negatively impact metabolic disorders, atherogenesis, and increase the cardiovascular (CV) risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9d752f04855e8f6f7293f71f3a3def8
https://doi.org/10.1136/annrheumdis-2022-eular.2647

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POS0912 THE EFFECT OF A 24-WEEK TRAINING ON METABOLIC PARAMETERS OF SKELETAL MUSCLE CELLS DERIVED FROM PATIENTS WITH ESTABLISHED IDIOPATHIC INFLAMMATORY MYOPATHIES

Autor: M. Vokurková, L. Vernerová, S. Oreska, M. Špiritović, M. Klein, Z. Verner, M. Nemec, J. Ukropec, B. Ukropcová, M. Tomčík, J. Vencovský

Publikováno v: Annals of the Rheumatic Diseases. 81:755.2-756

BackgroundPersistent muscle weakness after reduction of inflammation and resistance to immunosuppressive therapy in some patients with idiopathic inflammatory myopathies (IIM) suggest that not only immune but also non-immune mechanisms, such as mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae405086eb5791eb0833da6e91ba7ae
https://doi.org/10.1136/annrheumdis-2022-eular.4176

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POS0480 VITAMIN D AND ITS RECEPTOR (VDR) GENE EXPRESSION IN SKELETAL MUSCLE ASSOCIATE WITH DISEASE AND MUSCLE FUNCTION PARAMETERS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

Autor: L. Vernerová, M. Vokurková, S. Oreska, M. Špiritović, M. Klein, T. Kropackova, V. Horvathova, M. Tomčík, J. Ukropec, B. Ukropcová, J. Vencovský

Publikováno v: Annals of the Rheumatic Diseases. 81:495.1-495

BackgroundIdiopathic inflammatory myopathies (IIM) are chronic inflammatory disorders characterised, apart from extramuscular manifestations, by symmetrical progressive muscle weakness that may persist even after pharmacological suppression of inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b48630f545429a5d5accf603e97f8c13
https://doi.org/10.1136/annrheumdis-2022-eular.2598

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OP0208-HPR EFFECT OF AN 8-WEEK SPECIALIZED PHYSICAL THERAPY PROGRAM ON SEXUAL HEALTH IN FEMALE PATIENTS WITH SYSTEMIC SCLEROSIS AND IDIOPATHIC INFLAMMATORY MYOPATHIES: A PILOT STUDY

Autor: B. Heřmánková, M. Špiritović, S. Oreska, H. Štorkánová, K. Pavelka, L. Šenolt, J. Vencovský, R. Bečvář, M. Tomčík

Publikováno v: Annals of the Rheumatic Diseases. 81:136.1-136

BackgroundSystemic rheumatic diseases like systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM) may affect all aspects of life, including sexual health However, no non-pharmacological treatment has been proposed to date.ObjectivesThi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3d45ce621a57bef730f5dfb14a84fcb
https://doi.org/10.1136/annrheumdis-2022-eular.357

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OP0135 INHIBITION OF HSP90 REDUCES PROGRESSION OF DERMAL FIBROSIS AND INDUCES REGRESSION OF ESTABLISHED EXPERIMENTAL DERMAL FIBROSIS INDUCED BY BLEOMYCIN

Autor: H Storkanova, Maja Špiritović, Michal Tomcik, L. Štorkánová, Jiří Vencovský, Karel Pavelka, B. Heřmánková, Ladislav Šenolt, J. H. W. Distler, R. Bečvář, S. Oreska

Publikováno v: Annals of the Rheumatic Diseases. 79:87-88

Background:Our previous study demonstrated that Heat shock protein 90 (Hsp90) is overexpressed in the skin of patients with systemic sclerosis (SSc), in cultured SSc fibroblasts and preclinical models of SSc. HSP90 is a new regulator of canonical TGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::446a16fdfd0c3b241d3056e36c53fb46
https://doi.org/10.1136/annrheumdis-2020-eular.3597

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