Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

Autor: Michael Crompton, Joanne K. Ferguson, Raina D. Ramnath, Karen L. Onions, Anna S. Ogier, Monica Gamez, Colin J. Down, Laura Skinner, Kitty H. Wong, Lauren K. Dixon, Judit Sutak, Steven J. Harper, Paola Pontrelli, Loreto Gesualdo, Hiddo L. Heerspink, Robert D. Toto, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell, Matthew J. Butler

Publikováno v: JCI Insight, Vol 8, Iss 5 (2023)

The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria. In this study, we investigated wheth

Externí odkaz: https://doaj.org/article/359f2aff3fef4349ad8f0cd82c87577a

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Early mineralocorticoid receptor antagonism in diabetic nephropathy limits albuminuria by preserving the glomerular endothelial glycocalyx

Autor: Matthew J. Butler, Gavin I. Welsh, Steve J Harper, Joanne K. Ferguson, Raina D. Ramnath, Loreto Gesualdo, Anna S. Ogier, Rebecca R. Foster, Paola Pontrelli, Crompton M, Karen L. Onions, Simon C. Satchell, Skinner L, Sutak J, Dixon Lk, Colin J. Down

The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier (GFB). We have previously shown that excess mineralocorticoid receptor (MR) activation causes GEnGlx damage and albuminuria. Damage to the GEnGlx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::311ed3c486d3a7a28d7c0e32d1431941
https://doi.org/10.1101/2021.05.13.21252519

Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

Autor: Bilal Malik, Jennifer M. Dawson, James P Higham, Katie Lunnon, Anna S. Ogier, James J L Hodge, Edgar Buhl

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)
Higham, J, Malik, B R, Buhl, E, Dawson, J, Ogier, A S, Lunnon, K & Hodge, J 2019, ' Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila ', Frontiers in Cellular Neuroscience, vol. 13, 260 . https://doi.org/10.3389/fncel.2019.00260

Alzheimer's disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (Aβ) plaques. However, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35549fff5fee4ed29cc193ccc22da2e
https://www.frontiersin.org/article/10.3389/fncel.2019.00260/full