Accessing the impact of functional variants on human phenotypes by transcriptome analysis in individuals carrying different rSNP alleles

Autor: Victor Nedel'ko, Vladimir Berikov, L. O. Bryzgalov, S. N. Postovalov, Tatiana I. Merkulova, Elena E. Korbolina

Publikováno v: 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB).

the problem of functional annotation of regulatory single nucleotide polymorphisms is considered. Previously we have identified 1476 human regulatory SNPs through an integrated epigenome and transcriptome analysis. Here we employed the analysis of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e8886761fb820fb6148eaed52afb588
https://doi.org/10.1109/csgb51356.2020.9214706

A Panel of rSNPs Demonstrating Allelic Asymmetry in Both ChIP-seq and RNA-seq Data and the Search for Their Phenotypic Outcomes through Analysis of DEGs

Autor: Tatiana I. Merkulova, Elena E. Korbolina, Dmitry V. Poverin, Diana Z. Ustrokhanova, S. N. Postovalov, L. O. Bryzgalov, Igor S. Damarov

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7240, p 7240 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14

Currently, the detection of the allele asymmetry of gene expression from RNA-seq data or the transcription factor binding from ChIP-seq data is one of the approaches used to identify the functional genetic variants that can affect gene expression (re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f98fb0dc16fb9aced73a0811444e39
https://doi.org/10.3390/ijms22147240

Convergence Rate of Survival Function Estimator for Randomly Right-Censored Data

Autor: Petr Philonenko, S. N. Postovalov

Publikováno v: 2018 XIV International Scientific-Technical Conference on Actual Problems of Electronics Instrument Engineering (APEIE).

In the paper, we consider nonparametric estimators of survival functions (Kaplan-Meier and Nelson-Altshuler) for right-censored data. Also, we consider simulated results of convergence rate under various distributions of failure time. The simulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc0ae33272e4dfb8e730710f4217eb11
https://doi.org/10.1109/apeie.2018.8545966

Test power in two-sample problem testing as the utility function in the theory of decision making under risk and uncertainty

Autor: S. N. Postovalov, Petr Philonenko

Publikováno v: 2016 13th International Scientific-Technical Conference on Actual Problems of Electronics Instrument Engineering (APEIE).

In this paper, we construct types of alternative hypotheses for the test power research. For every type, it was obtained some alternative hypotheses that competing hypotheses are represented by various families of distribution. The test power is simu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8baa4d4c301436e792578f03ff90aabe
https://doi.org/10.1109/apeie.2016.7806491

The limit distribution of the maximum value test statistic in the general case

Autor: S. N. Postovalov, Artem Kovalevskii, Petr Philonenko

Publikováno v: 2016 11th International Forum on Strategic Technology (IFOST).

The formula of the limit distribution of the maximum value test statistic is represented in the general case in this paper. The formula provides a precise calculation of a p-value in hypothesis testing. Also, the proof is represented in this paper.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f881b04f251ace0876859a453c426602
https://doi.org/10.1109/ifost.2016.7884145