Zobrazeno 1 - 10
of 258
pro vyhledávání: '"S. Munir Alam"'
Autor:
Richard H.C. Huntwork, Kan Li, S. Munir Alam, Gillian Q. Horn, S. Moses Dennison, Georgia D. Tomaras
Publikováno v:
Gates Open Research, Vol 7 (2024)
Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data
Externí odkaz:
https://doaj.org/article/f4b13b8adadf451582e8703d9c6ff61c
Autor:
Rory Henderson, Ye Zhou, Victoria Stalls, Kevin Wiehe, Kevin O. Saunders, Kshitij Wagh, Kara Anasti, Maggie Barr, Robert Parks, S. Munir Alam, Bette Korber, Barton F. Haynes, Alberto Bartesaghi, Priyamvada Acharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine desig
Externí odkaz:
https://doaj.org/article/a0c3383f4920484ea23242df323c4d69
Autor:
Richard H.C. Huntwork, Kan Li, S. Munir Alam, Gillian Q. Horn, S. Moses Dennison, Georgia D. Tomaras
Publikováno v:
Gates Open Research, Vol 7 (2023)
Label-free techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) are biophysical tools widely used to collect binding kinetics data of bimolecular interactions. To efficiently analyze SPR and BLI binding kinetics data
Externí odkaz:
https://doaj.org/article/76eced313d954d1eb22f73ec45e0c79b
Autor:
Ashley N. Nelson, Maria Dennis, Jesse F. Mangold, Katherine Li, Pooja T. Saha, Kenneth Cronin, Kaitlyn A. Cross, Amit Kumar, Riley J. Mangan, George M. Shaw, Katharine J. Bar, Barton Haynes, Anthony M. Moody, S. Munir Alam, Justin Pollara, Michael G. Hudgens, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The development of a maternal HIV vaccine to synergize with current antiretroviral drug prophylaxis can overcome implementation challenges and further reduce mother-to-child transmission (MTCT) of HIV. Both the epitope-specificity and autolo
Externí odkaz:
https://doaj.org/article/0b0d44ecc1e745dcb581c54bee8b031d
Autor:
Dapeng Li, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, Kevin Wiehe, Richard M. Scearce, Maggie Barr, Zekun Mu, Robert Parks, Max Quastel, Robert J. Edwards, Yunfei Wang, Wes Rountree, Kevin O. Saunders, Guido Ferrari, Persephone Borrow, E. Yvonne Jones, S. Munir Alam, Mihai L. Azoitei, Geraldine M. Gillespie, Andrew J. McMichael, Barton F. Haynes
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.
Externí odkaz:
https://doaj.org/article/059bf3a2d5d44706ba2a0a0de0b49e26
Autor:
Kan Li, Michael Dodds, Rachel L. Spreng, Milite Abraha, Richard H. C. Huntwork, Lindsay C. Dahora, Tinashe Nyanhete, Sheetij Dutta, Ulrike Wille-Reece, Erik Jongert, Katie J. Ewer, Adrian V. S. Hill, Celina Jin, Jennifer Hill, Andrew J. Pollard, S. Munir Alam, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diversity in specificity of polyclonal antibody (pAb) responses is extensively investigated in vaccine efficacy or immunological evaluations, but the heterogeneity in antibody avidity is rarely probed as convenient tools are lacking. Here we have dev
Externí odkaz:
https://doaj.org/article/daa2eeeb0ae945ebaa3a3cfd1fe010ec
Autor:
Frederic Bibollet-Ruche, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N. Skelly, Ryan S. Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, John W. Carey, Andrew Jesse Connell, Hui Li, Elena E. Giorgi, Ge S. Song, Shilei Ding, Andrés Finzi, Amanda Newman, Giovanna E. Hernandez, Emily Machiele, Derek W. Cain, Katayoun Mansouri, Mark G. Lewis, David C. Montefiori, Kevin J. Wiehe, S. Munir Alam, I-Ting Teng, Peter D. Kwong, Raiees Andrabi, Laurent Verkoczy, Dennis R. Burton, Bette T. Korber, Kevin O. Saunders, Barton F. Haynes, Robert J. Edwards, George M. Shaw, Beatrice H. Hahn
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the immunogenicity of germ line-targeting versions of a chimpanzee SIV
Externí odkaz:
https://doaj.org/article/3b93383f6dad4c28967afedad78671dd
Autor:
Kelly E. Seaton, Rachel L. Spreng, Milite Abraha, Matthew Reichartz, Michelle Rojas, Frederick Feely, Richard H. C. Huntwork, Sheetij Dutta, Sarah V. Mudrak, S. Munir Alam, Scott Gregory, Erik Jongert, Margherita Coccia, Fernando Ulloa-Montoya, Ulrike Wille-Reece, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract RTS,S/AS01 is an advanced pre-erythrocytic malaria vaccine candidate with demonstrated vaccine efficacy up to 86.7% in controlled human malaria infection (CHMI) studies; however, reproducible immune correlates of protection (CoP) are elusive
Externí odkaz:
https://doaj.org/article/0219a60f06354a4495a0f6088c161287
Autor:
Alan D. Curtis, Pooja T. Saha, Maria Dennis, Stella J. Berendam, Pratamesh Ramasubramanian, Kaitlyn A. Cross, S. Munir Alam, Guido Ferrari, Pamela A. Kozlowski, Genevieve G. Fouda, Michael G. Hudgens, Koen K. A. Van Rompay, Justin Pollara, Sallie R. Permar, Kristina De Paris
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Improved access to antiretroviral therapy (ART) and antenatal care has significantly reduced in utero and peripartum mother-to-child human immunodeficiency virus (HIV) transmission. However, as breast milk transmission of HIV still occurs at
Externí odkaz:
https://doaj.org/article/9e19cbc41f434c66ad45f4c532807065
Autor:
Rory Henderson, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, Elizabeth Carter, Scott C. Blanchard, R J Edwards, Kevin Wiehe, Kevin O. Saunders, Mario J. Borgnia, Alberto Bartesaghi, Walther Mothes, Barton F. Haynes, Priyamvada Acharya, S. Munir Alam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has importan
Externí odkaz:
https://doaj.org/article/66b0bc924f5e41b8ab9751e365c7c967