Acute kidney injury in patients treated with immune checkpoint inhibitors

Autor: Joe-Elie Salem, Enriqueta Felip, Sophie Papa, Shuchi Anand, Karolina Benesova, Marlies Ostermann, Ala Abudayyeh, Omar Mamlouk, Umut Selamet, Grace Cherry, Sunandana Chandra, Sandra M Herrmann, Maria Jose Soler, Abhijat Kitchlu, Jamie S Lin, Kerry L Reynolds, Osama E Rahma, Elizabeth M Gaughan, Eva Muñoz-Couselo, Jamie S Hirsch, Pablo Garcia, Meghan D Lee, Harish Seethapathy, Ian A Strohbehn, Meghan E Sise, Wei-Ting Chang, Els Wauters, Lucy Flanders, Deborah Schrag, Thibaud Koessler, Mark Eijgelsheim, Shruti Gupta, Frank B Cortazar, Samuel A P Short, Jason M Prosek, Sethu M Madhavan, Ilya Glezerman, Shveta S Motwani, Naoka Murakami, Rimda Wanchoo, David I Ortiz-Melo, Arash Rashidi, Ben Sprangers, Vikram Aggarwal, A Bilal Malik, Sebastian Loew, Christopher A Carlos, Pazit Beckerman, Zain Mithani, Chintan V Shah, Amanda D Renaghan, Sophie De Seigneux, Luca Campedel, Daniel Sanghoon Shin, Sunil Rangarajan, Priya Deshpande, Gaia Coppock, Dwight H. Owen, Marium Husain, Clara Garcia-Carro, Sheila Bermejo, Nuttha Lumlertgul, Nina Seylanova, Busra Isik, Aydin Kaghazchi, Yuriy Khanin, Sheru K Kansal, Kai M Schmidt-Ott, Raymond K Hsu, Maria C Tio, Suraj Sarvode Mothi, Harkarandeep Singh, Kenar D Jhaveri, David E Leaf, Corinne Isnard Bagnis, Suraj S Mothi, Weiting Chang, Vipulbhai Sakhiya, Daniel Stalbow, Sylvia Wu, Armando Cennamo, Anne Rigg, Nisha Shaunak, Zoe A Kibbelaar, Harish S Seethapathy, Meghan Lee, Ian A Strohbhen, Ilya G Glezerman, Dwight H Owen, Sharon Mini, Andrey Kisel, Nicole Albert, Katherine Carter, Vicki Donley, Tricia Young, Heather Cigoi, Els Wauters Ben Sprangers, Javier A Pagan, Jonathan J Hogan, Valda Page, Samuel AP Short, Maria Josep Carreras

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)

Background Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer.Methods We collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis conte

Externí odkaz: https://doaj.org/article/f9d13db10fbd4d48a6d213cfb0b136b5

Bi-directional cell-pericellular matrix interactions direct stem cell fate

Autor: Silvia A. Ferreira, Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders, Laurent Bozec, Eileen Gentleman

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone ma

Externí odkaz: https://doaj.org/article/8af8d8a81ddc405d9f52c6d4512ee247

Immune-related adverse events and kidney function decline in patients with genitourinary cancers treated with immune checkpoint inhibitors

Autor: Harish Seethapathy, Sarah Street, Xiao Wei, Shveta S. Motwani, Kerry L. Reynolds, Toni K. Choueiri, Nifasha Rusibamayila, Ian A. Strohbehn, Meghan Lee, M.D. Michaelson, Brad McGregor, Cristina Salabao, Guru Sonpavde, Meghan E. Sise, David E. Leaf, Shruti Gupta, Sophia H. Zhao, Donald F. Chute, Xin Gao, Marina D. Kaymakcalan, Osama E. Rahma

Publikováno v: European Journal of Cancer. 157:50-58

Background In patients with genitourinary cancers, the effect of immune checkpoint inhibitors (ICIs) on kidney function is unknown. Patients and methods This is a retrospective cohort study of patients with renal cell carcinoma (RCC) and urothelial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d132ad8ecb60264419c2c2046cf17c69
https://doi.org/10.1016/j.ejca.2021.07.031

Incidence and Clinical Features of Immune-Related Acute Kidney Injury in Patients Receiving Programmed Cell Death Ligand-1 Inhibitors

Autor: Alexandra-Chloé Villani, Shruti Gupta, David E. Leaf, Leyre Zubiri, Ryan J. Sullivan, Ian A. Strohbehn, Gabriel E. Molina, Meghan E. Sise, Harish Seethapathy, Osama E. Rahma, Halla Bates, Kerry L. Reynolds, Sophia Zhao, Shveta S. Motwani, Meghan Lee, Donald F. Chute, Kimberly G. Blumenthal

Publikováno v: Kidney International Reports, Vol 5, Iss 10, Pp 1700-1705 (2020)
Kidney International Reports

Background Programmed cell death receptor ligand 1 (PD-L1) inhibitors are immune checkpoint inhibitors (ICIs) with a side effect profile that may differ from other classes of ICIs such as those directed against cytotoxic T-lymphocyte−associated pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8166db7c8fae1e7b841af8f6cf53655a
https://doi.org/10.1016/j.ekir.2020.07.011

Efficacy of a collagen hydrolysate and antioxidants‐containing nutraceutical on metrics of skin health in Indian women

Autor: Meghna S. Motwani, Kaynat Khan, Akshay Pai, Rajiv Joshi

Publikováno v: Journal of Cosmetic Dermatology. 19:3371-3382

Background The skin's aging process involves a decreased biosynthesis of extracellular matrix proteins (predominantly collagen) compounded by damage from environmental and intrinsic stressors. The Indian population is susceptible to skin damage given

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c0a106a1de19a7bf20058e32bf5b20
https://doi.org/10.1111/jocd.13404