Zobrazeno 1 - 10
of 288
pro vyhledávání: '"S. Milliken"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 13 (2022)
Background The metabolite succinate accumulates during cardiac ischemia. Within 5 minutes of reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by mitochondrial complex II. The latter drives reactive oxyge
Externí odkaz:
https://doaj.org/article/9215f15c122a41b89f7364e581557029
Publikováno v:
Journal of Molecular and Cellular Cardiology. 174:101-114
Tissue ischemia results in intracellular pH (pHIN) acidification, and while accumulation of metabolites such as lactate is a known driver of acidic pHIN, less is known about how acidic pHIN regulates metabolism. Furthermore, acidic extracellular (pHE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d442ee7a304cd1945940ef2f4df9da
https://doi.org/10.1016/j.yjmcc.2022.11.008
https://doi.org/10.1016/j.yjmcc.2022.11.008
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101733- (2020)
Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxida
Externí odkaz:
https://doaj.org/article/6df572c42a034fb3a50377e0f68f0b66
Publikováno v:
2022 IEEE 22nd International Conference on Nanotechnology (NANO).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d579a52810ee82b985012e5bd8d5aad
https://doi.org/10.1109/nano54668.2022.9928711
https://doi.org/10.1109/nano54668.2022.9928711
Autor:
David van der Poorten, Mahsa Shahidi, Enoch Tay, Jayshree Sesha, Kayla Tran, Duncan McLeod, Jane S Milliken, Vikki Ho, Lionel W Hebbard, Mark W Douglas, Jacob George
Publikováno v:
PLoS ONE, Vol 5, Iss 9, Pp 3307-3314 (2010)
BACKGROUND: Activation of hepatic CB(1) receptors (CB(1)) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB(1) expression has not been assessed in patients with chronic hepatitis C (CHC), a disease associat
Externí odkaz:
https://doaj.org/article/7944bd3364c548d7af9d7c080140828d
Publikováno v:
Circulation Research. 129
Succinate is a metabolite that plays a central role in ischemia-reperfusion (IR) injury,which is relevant to myocardial infarction (heart attack) and stroke. Succinateaccumulates during ischemia and is rapidly consumed at reperfusion driving reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ab7a37f725465004191ac2adc192c4
https://doi.org/10.1161/res.129.suppl_1.p311
https://doi.org/10.1161/res.129.suppl_1.p311
Akademický článek
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Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6182b2e6b8423dac3afa85c6cec428b9
https://doi.org/10.1101/2020.08.31.275438
https://doi.org/10.1101/2020.08.31.275438
Autor:
Aimin Peng, Paul C. Trippier, Myla Bhakta, Alexander S. Milliken, Feifei Wang, Paul S. Brookes, Chaitanya A. Kulkarni, Bader Huwaimel
Publikováno v:
ChemMedChem
Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells including the benzothiadiazine-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59306996d22cf8e95ace49ea48c8b3df
https://doi.org/10.26434/chemrxiv.12350912.v2
https://doi.org/10.26434/chemrxiv.12350912.v2
Akademický článek
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