Zobrazeno 1 - 10
of 497
pro vyhledávání: '"S. McCune"'
Autor:
Ezhilpavai Mohanan, Guofang Shen, Suping Ren, Hsuan‐Hao Fan, Kao Tang Ying Moua, Aleksandra Karolak, Russell C. Rockne, Ryotaro Nakamura, David A. Horne, Christopher G. Kanakry, Donald E. Mager, Jeannine S. McCune
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Dose optimization of sirolimus may further improve outcomes in allogeneic hematopoietic cell transplant (HCT) patients receiving post‐transplantation cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD). Sirolimus exposu
Externí odkaz:
https://doaj.org/article/1ad61f5066c845a0a3e42d38aae318d1
Autor:
Jeannine S. McCune, Sandi L. Navarro, Linda J. Risler, Brian R. Phillips, Suping Ren, H. Gary Schoch, K. Scott Baker
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2577-2590 (2023)
Abstract Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ‐glutamyldehydroalanylglycine, which is too unstable to be quantitate
Externí odkaz:
https://doaj.org/article/ceb3802b92a543fb95917bf8b6076114
Autor:
John D. Clarke, Sabrina M. Judson, Dan‐Dan Tian, Trevor O. Kirby, Rakshit S. Tanna, Adrienn Matula‐Péntek, Miklós Horváth, Matthew E. Layton, John R. White, Nadja B. Cech, Kenneth E. Thummel, Jeannine S. McCune, Danny D. Shen, Mary F. Paine
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1779-1790 (2023)
Abstract Green tea is a popular beverage worldwide. The abundant green tea catechin (−)‐epigallocatechin gallate (EGCG) is a potent in vitro inhibitor of intestinal UDP‐glucuronosyltransferase (UGT) activity (Ki ~2 μM). Co‐consuming green te
Externí odkaz:
https://doaj.org/article/3dfbcc53952945d38b75f821bdee7633
Autor:
Sandi L. Navarro, Zihan Zheng, Timothy W. Randolph, Ryotaro Nakamura, Brenda M. Sandmaier, David Hockenbery, Jeannine S. McCune
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2772-2780 (2022)
Abstract Biomarker‐guided dosing may improve the efficacy and toxicity of cyclophosphamide (CY); however, clinical studies evaluating their association with the area under the plasma concentration–time curve (AUC) of CY and its metabolites are ti
Externí odkaz:
https://doaj.org/article/034d5c4902d8493c9cf868fe1012af57
Autor:
Jeannine S. McCune, Ryotaro Nakamura, Denis O’Meally, Timothy W. Randolph, Brenda M. Sandmaier, Aleksandra Karolak, David Hockenbery, Sandi L. Navarro
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 5, Pp 1215-1224 (2022)
Abstract The widely used alkylating agent cyclophosphamide (CY) has substantive interpatient variability in the area under the curve (AUC) of it and its metabolites. Numerous factors may influence the drug‐metabolizing enzymes that metabolize CY to
Externí odkaz:
https://doaj.org/article/fe9f7319ce1b423986ecf0e94f900ca7
Autor:
Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 322-329 (2022)
Abstract Pharmacokinetic drug interactions precipitated by botanical and other natural products (NPs) remain critically understudied. Investigating these complex interactions is fraught with difficulties due to the methodologic and technical challeng
Externí odkaz:
https://doaj.org/article/e20efd409a5441c4bdc59083edd30142
Autor:
Guofang Shen, Kao Tang Ying Moua, Kathryn Perkins, Deron Johnson, Arthur Li, Peter Curtin, Wei Gao, Jeannine S. McCune
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopoietic cell). Precision dosing of sirolimus using thera
Externí odkaz:
https://doaj.org/article/32452f3de8ad4e33b844556ccb0e0d46
Autor:
Saro H. Armenian, Aleksi Iukuridze, Jennifer Berano Teh, Kristen Mascarenhas, Alex Herrera, Jeannine S. McCune, Jasmine M. Zain, Sogol Mostoufi‐Moab, Shana McCormack, Thomas P. Slavin, Jessica M. Scott, Lee W. Jones, Can‐Lan Sun, Stephen J. Forman, F. Lennie Wong, Ryotaro Nakamura
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 962-972 (2020)
Abstract Background The number of patients undergoing autologous haematopoietic cell transplant (HCT) is growing, but little is known about the factors that predict adverse outcomes. Low muscle mass and obesity are associated with disability and prem
Externí odkaz:
https://doaj.org/article/1022c52af32b4a3caf8a53954993d0ac
Autor:
Mohamed L. Sorror, Ted A. Gooley, Barry E. Storer, Aaron T. Gerds, Mikkael A. Sekeres, Bruno C. Medeiros, Eunice S. Wang, Paul J. Shami, Kehinde Adekola, Selina Luger, Maria R. Baer, David A. Rizzieri, Tanya M. Wildes, Jamie Koprivnikar, Julie Smith, Mitchell Garrison, Kiarash Kojouri, Tammy A. Schuler, Wendy M. Leisenring, Lynn E. Onstad, Pamela S. Becker, Jeannine S. McCune, Stephanie J. Lee, Brenda M. Sandmaier, Frederick R. Appelbaum, Elihu H. Estey
Publikováno v:
Blood. 141:295-308
We designed a prospective, observational study enrolling patients presenting for treatment of acute myeloid leukemia (AML) at 13 institutions to analyze associations between hematopoietic cell transplantation (HCT) and survival, quality of life (QOL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18ac43f88e08919cf31ab19bf2deca
https://doi.org/10.1182/blood.2022016916
https://doi.org/10.1182/blood.2022016916
Autor:
Veronica C. Jones, Eric C. Dietze, Tijana Jovanovic-Talisman, Jeannine S. McCune, Victoria L. Seewaldt
Publikováno v:
Frontiers in Public Health, Vol 8 (2020)
Currently, tamoxifen is the only drug approved for reduction of breast cancer risk in premenopausal women. The significant cardiovascular side effects of tamoxifen, coupled with lack of a survival benefit, potential for genotoxicity, and failure to p
Externí odkaz:
https://doaj.org/article/6718832c005c4fdfbdc679acf3cf2f49